DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5973 and CLVS2

DIOPT Version :9

Sequence 1:	NP_001162901.1	Gene:	CG5973 / 34023	FlyBaseID:	FBgn0031914	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens

Alignment Length:	288	Identity:	88/288 - (30%)
Similarity:	139/288 - (48%)	Gaps:	32/288 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 APEWALKKAQDELREVPGVKEQAIKELRELIQNEKYLN-LPLDDEYMMMFLRPTHYYPESALKRL 94
            :|| .|:||:.||.|.|....|.|:|:|:::.....:. |..||.:::.|||...::...|.:.|
Human     9 SPE-TLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLL 72

  Fly    95 KNFYHMK------LKYGAACENIIPSKLRNVFEANILNLLPQRDQHGRRLLVLEAGKKWKPSQVP 153
            ..::..:      .|...|.:..|...|::.|...:.||    |.:||::|||.|. .|..|:..
Human    73 AQYFEYRQQNLDMFKSFKATDPGIKQALKDGFPGGLANL----DHYGRKILVLFAA-NWDQSRYT 132

  Fly   154 LVDLFRGIQLTVLGSMVEPYSQICGSVVIIDMEGLPLSHITQFTPSFAAMLLDYIQECICMRLKA 218
            |||:.|.|.|::...:.:|..|:.|.|:|||.........::.|||...:.::.:|:....|...
Human   133 LVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGG 197

  Fly   219 VHIVNNSYIFNMLFAVFKPFIREKLRKRIFFHGKDYKSLISHIEAKALPPKYGG------SATWE 277
            :|.||..:..:.|:.|.:||::||.|||||.||.:..||...|..:.||.::||      ..||.
Human   198 IHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTWA 262

  Fly   278 ---LPHGKVLGEFFECYSKDYEL-ADSY 301
               |.|.         |..|.|. .|||
Human   263 RTLLDHE---------YDDDSEYNVDSY 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5973	NP_001162901.1	CRAL_TRIO_N	51..96	CDD:215024	12/45 (27%)
CG5973	NP_001162901.1	SEC14	116..272	CDD:238099	52/155 (34%)
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	12/45 (27%)
		SEC14	106..251	CDD:238099	50/149 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59833
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8539
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830