DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5958 and Sec14l1

DIOPT Version :9

Sequence 1:	NP_609119.2	Gene:	CG5958 / 34022	FlyBaseID:	FBgn0031913	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	253	Identity:	57/253 - (22%)
Similarity:	115/253 - (45%)	Gaps:	43/253 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LRETEEVKAEAIIKLRELLKATPELNYKDDDAFLTVFLRACHFYPEGALEKMKTTASFRKEYASL 94
            |.:...::...:|:||:.|:.|.:.....|:..|. ||||..|..:.|.|.|..:.::||::.
Mouse   248 LGDLTPLQESCLIRLRQWLQETHKGKIPKDEHILR-FLRARDFNIDKAREIMCQSLTWRKQHQ-- 309

  Fly    95 VRGLLVEQVKEKFVKGSVI-----NVLKNCDQKGRRVLIVNCGKLWDPSDIT----SDEMFRMLY 150
                 |:.:.:.:....|:     ....:.|:.||.:.::..|:: |...:.    .:.:.|.:.
Mouse   310 -----VDYILDTWTPPQVLLDYYAGGWHHHDKDGRPLYVLRLGQM-DTKGLVRALGEEALLRYVL 368

  Fly   151 MVHLAA--QLEEETQVRG-----VVCIMDFEGLSMKQ-----VKALSPSFSKRLLTFIQEAMPLR 203
            .::...  :.||.|:|.|     ..|::|.|||:|:.     ||||     .|::..::...|..
Mouse   369 SINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKAL-----LRIIEVVEANYPET 428

  Fly   204 MKEVHFVKQPFIFNMVWSLFKPFVKQKLNNRMHF---HGSDMK---SLQKFLDPSVLP 255
            :..:..::.|.:|.::|:|..||:..  |.|..|   .|:|.:   .|..::|..::|
Mouse   429 LGRLLILRAPRVFPVLWTLVSPFIDD--NTRRKFLIYAGNDYQGPGGLLDYIDKEIIP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5958	NP_609119.2	CRAL_TRIO_N	38..82	CDD:215024	14/43 (33%)
CG5958	NP_609119.2	CRAL_TRIO	111..261	CDD:279044	38/172 (22%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		57/253 (23%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024	15/45 (33%)
		CRAL_TRIO	326..490	CDD:279044	37/167 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810