DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5958 and TTPA

DIOPT Version :9

Sequence 1:	NP_609119.2	Gene:	CG5958 / 34022	FlyBaseID:	FBgn0031913	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_000361.1	Gene:	TTPA / 7274	HGNCID:	12404	Length:	278	Species:	Homo sapiens

Alignment Length:	238	Identity:	72/238 - (30%)
Similarity:	117/238 - (49%)	Gaps:	36/238 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DAFLTVFLRACHFYPEGALEKMKTTASFRKEYASL--------VRGLLVEQVKEKFVKGSVINVL 116
            |:||..||||..|..:.|...:|....:|.|...:        :.|||         |.....||
Human    49 DSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLL---------KAGYHGVL 104

  Fly   117 KNCDQKGRRVLIVNCGKLWDPSDITSDEMFRMLYMVHLAAQLEEETQVRGVVCIMDFEGLSMKQV 181
            ::.|..|.:|||..... |||...|:.::||:..:.......|.|||..|:..|.|.||......
Human   105 RSRDPTGSKVLIYRIAH-WDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHA 168

  Fly   182 KALSPSFSKRLLTFIQEAMPLRMKEVHFVKQPFIFNMVWSLFKPFVKQKLNNRMHFHGSDMKS-- 244
            ..::||.:|::...:.::.||:::.:|.:.:|.||:.|:|:.|||:.:|:..|:|.||::.|.
Human   169 FQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSL 233

  Fly   245 LQKFLDPSVLPANYKGTLPAIDYGGVEWFPALEQQAQYVEEWS 287
            ||.|  |.:||         ::|||.|:  ::|...|   ||:
Human   234 LQHF--PDILP---------LEYGGEEF--SMEDICQ---EWT 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5958	NP_609119.2	CRAL_TRIO_N	38..82	CDD:215024	9/21 (43%)
CG5958	NP_609119.2	CRAL_TRIO	111..261	CDD:279044	48/151 (32%)
TTPA	NP_000361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CRAL_TRIO_N	<40..73	CDD:215024	10/23 (43%)
		CRAL_TRIO	99..248	CDD:395525	50/160 (31%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q8BWP5	208..211		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1053004at2759
OrthoFinder	1	1.000	-	-		FOG0000233
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920