DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment muc and LAT1

DIOPT Version :9

Sequence 1:	NP_001260196.1	Gene:	muc / 34021	FlyBaseID:	FBgn0283658	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_014328.3	Gene:	LAT1 / 855653	SGDID:	S000005015	Length:	482	Species:	Saccharomyces cerevisiae

Alignment Length:	513	Identity:	204/513 - (39%)
Similarity:	296/513 - (57%)	Gaps:	69/513 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RRSTGNVVVRALSSQLINSRKLQSIRSKLNTSQSPVTWSYNFARAYANLPEHIRVPLPALSPTME 93
            |.|..:|:.|:|..||                           |.||:.|||..:.:|||||||.
Yeast    10 RISRSSVLTRSLRLQL---------------------------RCYASYPEHTIIGMPALSPTMT 47

  Fly    94 RGSIVSWEKKEGDKLNEGDLLCEIETDKATMGFETPEEGFLAKILIQGGTKDVPVGQLLCIIVPD 158
            :|::.:|.|||||:|:.|:::.|||||||.|.||..|:|:|||||:..||||:||.:.:.:.|.|
Yeast    48 QGNLAAWTKKEGDQLSPGEVIAEIETDKAQMDFEFQEDGYLAKILVPEGTKDIPVNKPIAVYVED 112

  Fly   159 QGSVAAFANFK-DDGAAAAPAAPAAAPAPAPAAAAAPPPPPPPAAAPAAAAPPPAPAA--APAAA 220
            :..|.||.:|| :|..:.:..:..|.|        |.|.......|||......||.|  :..||
Yeast   113 KADVPAFKDFKLEDSGSDSKTSTKAQP--------AEPQAEKKQEAPAEETKTSAPEAKKSDVAA 169

  Fly   221 GTGRVYASPMAKRLAEAQQLRLQG-KGSGVHGSIKSGDL-------------AGQKAAAKPAAAA 271
            ..||::|||:||.:|..:.:.|:. .|:|..|.|...|:             ....|||.||||.
Yeast   170 PQGRIFASPLAKTIALEKGISLKDVHGTGPRGRITKADIESYLEKSSKQSSQTSGAAAATPAAAT 234

  Fly   272 PA----KAPR-AAGARYEDIPVTNMRAVIAKRLLESKTQLPHYYVTVQCQVDKLLKFR----AKV 327
            .:    .||. ::.|.|||:|::.||::|.:|||:|...:|.|.|:.:..:.||||.|    |..
Yeast   235 SSTTAGSAPSPSSTASYEDVPISTMRSIIGERLLQSTQGIPSYIVSSKISISKLLKLRQSLNATA 299

  Fly   328 NKKYEKQGARVSVNDFIIKAVAIASLKVPEANSAWM--DTVIRKYDDVDVSVAVSTDKGLITPIV 390
            |.||     ::|:||.::||:.:|:.:||:||:.|:  :.||||:.:|||||||:|..||:||||
Yeast   300 NDKY-----KLSINDLLVKAITVAAKRVPDANAYWLPNENVIRKFKNVDVSVAVATPTGLLTPIV 359

  Fly   391 FNADRKGVLEISKDVKALAAKARDNKLQPHEFQGGTISVSNLGM-FGVNQFAAVINPPQSCILAI 454
            .|.:.||:.:||.::|.|..:||.|||.|.|||||||.:||:|| ..||.|.::||||||.||||
Yeast   360 KNCEAKGLSQISNEIKELVKRARINKLAPEEFQGGTICISNMGMNNAVNMFTSIINPPQSTILAI 424

  Fly   455 GTTTKQLVADPDSLKGFKEVNMLTVTLSADHRVVDGAVAARWLQHFRDYMEDPSNMVL 512
            .|..:..|.|..:..||...|.:|:|.:.|||.:|||..|.:::..:..:|:|..|:|
Yeast   425 ATVERVAVEDAAAENGFSFDNQVTITGTFDHRTIDGAKGAEFMKELKTVIENPLEMLL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muc	NP_001260196.1	PDHac_trf_mito	83..512	CDD:273567	190/457 (42%)
		lipoyl_domain	83..155	CDD:133458	39/71 (55%)
		2-oxoacid_dh	299..512	CDD:278621	99/219 (45%)
LAT1	NP_014328.3	PDHac_trf_mito	36..482	CDD:273567	190/458 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345367
Domainoid	1	1.000	207	1.000	Domainoid score	I524
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6814
Inparanoid	1	1.050	341	1.000	Inparanoid score	I411
Isobase	1	0.950	-	0	Normalized mean entropy	S865
OMA	1	1.010	-	-		QHG62888
OrthoFinder	1	1.000	-	-		FOG0001572
OrthoInspector	1	1.000	-	-		oto99200
orthoMCL	1	0.900	-	-		OOG6_101258
Panther	1	1.100	-	-	LDO	PTHR23151
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R863
SonicParanoid	1	1.000	-	-		X2175
TreeFam	1	0.960	-	-
	16	15.740