DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment muc and LTA3

DIOPT Version :9

Sequence 1:NP_001260196.1 Gene:muc / 34021 FlyBaseID:FBgn0283658 Length:512 Species:Drosophila melanogaster
Sequence 2:NP_001190070.1 Gene:LTA3 / 824385 AraportID:AT3G52200 Length:713 Species:Arabidopsis thaliana


Alignment Length:466 Identity:190/466 - (40%)
Similarity:258/466 - (55%) Gaps:63/466 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 ANLPEHIRVPLPALSPTMERGSIVSWEKKEGDKLNEGDLLCEIETDKATMGFETPEEGFLAKILI 139
            ::||.|:.:.:|||||||.:|:|..|.||||||:..||::.||||||||:.||:.|||:||||||
plant   283 SDLPPHVVLEMPALSPTMNQGNIAKWWKKEGDKIEVGDVIGEIETDKATLEFESLEEGYLAKILI 347

  Fly   140 QGGTKDVPVGQLLCIIVPDQGSVAAFANFKDDGAAAAPAAPAAAPAPAPAAAAAPPPPPPPAAAP 204
            ..|:|||.||:.:.:||.|..|:.|   .|...|.:                         :...
plant   348 PEGSKDVAVGKPIALIVEDAESIEA---IKSSSAGS-------------------------SEVD 384

  Fly   205 AAAAPPPAPAAAPAAAGTGRVYASPMAKRL-----AEAQQLRLQGK-----GSGVHGSIKSGDLA 259
            .....|.:....|.....|....||.||.|     .||..:...|.     .|.|..:|.||..:
plant   385 TVKEVPDSVVDKPTERKAGFTKISPAAKLLILEHGLEASSIEASGPYGTLLKSDVVAAIASGKAS 449

  Fly   260 GQKAAAK---PAAAAPAKAPRA-------AGARYEDIPVTNMRAVIAKRLLESKTQLPHYYVTVQ 314
            ...|:.|   |:...|:|:...       :...|||.|.:.:|.:|||||||||.::||.|:...
plant   450 KSSASTKKKQPSKETPSKSSSTSKPSVTQSDNNYEDFPNSQIRKIIAKRLLESKQKIPHLYLQSD 514

  Fly   315 CQVDKLLKFRAKVNKKYEKQGARVSVNDFIIKAVAIASLKVPEANSAW----MDTVIRKYDDVDV 375
            ..:|.||.||.::.   |..|.:|||||.:|||||:|...|.:||:.|    .|.|:  .|.||:
plant   515 VVLDPLLAFRKELQ---ENHGVKVSVNDIVIKAVAVALRNVRQANAFWDAEKGDIVM--CDSVDI 574

  Fly   376 SVAVSTDKGLITPIVFNADRKGVLEISKDVKALAAKARDNKLQPHEFQGGTISVSNLGMFGVNQF 440
            |:||:|:|||:|||:.|||:|.:..||.:||.||.|||..||.||||||||.|:|||||:.|:.|
plant   575 SIAVATEKGLMTPIIKNADQKSISAISLEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDNF 639

  Fly   441 AAVINPPQSCILAIGTTTKQLVADP----DSLKGFKEVNMLTVTLSADHRVVDGAVAARWLQHFR 501
            .|:|||||:.|||:|...|  |.:|    |.::....|..:.||||||||:.||.|.|.::...|
plant   640 CAIINPPQAGILAVGRGNK--VVEPVIGLDGIEKPSVVTKMNVTLSADHRIFDGQVGASFMSELR 702

  Fly   502 DYMEDPSNMVL 512
            ...||...::|
plant   703 SNFEDVRRLLL 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mucNP_001260196.1 PDHac_trf_mito 83..512 CDD:273567 186/456 (41%)
lipoyl_domain 83..155 CDD:133458 43/71 (61%)
2-oxoacid_dh 299..512 CDD:278621 106/220 (48%)
LTA3NP_001190070.1 lipoyl_domain 166..236 CDD:133458
lipoyl_domain 289..363 CDD:133458 43/73 (59%)
PDHac_trf_mito 290..713 CDD:273567 186/457 (41%)
E3_binding 406..439 CDD:280908 9/32 (28%)
2-oxoacid_dh 499..713 CDD:278621 106/220 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 100 1.000 Domainoid score I2350
eggNOG 1 0.900 - - E1_COG0508
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D747232at2759
OrthoFinder 1 1.000 - - FOG0001572
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2175
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
76.780

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