DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment muc and pdhx

DIOPT Version :9

Sequence 1:	NP_001260196.1	Gene:	muc / 34021	FlyBaseID:	FBgn0283658	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_956854.2	Gene:	pdhx / 393532	ZFINID:	ZDB-GENE-040426-1539	Length:	496	Species:	Danio rerio

Alignment Length:	516	Identity:	206/516 - (39%)
Similarity:	293/516 - (56%)	Gaps:	63/516 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RSTGNVVVRALSSQLINSRKLQSIRSKLNTSQSPVTWS-------YNFARAYANL-PEHIRVPLP 86
            |.|....:|||:.   ....|||.......|..|..||       |...||.|.: |  ::|.:|
Zfish     9 RRTLFTALRALTQ---TPAGLQSSFRPPRESPRPAGWSRSAARPLYQSCRARAGVCP--LKVQMP 68

  Fly    87 ALSPTMERGSIVSWEKKEGDKLNEGDLLCEIETDKATMGFETPEEGFLAKILIQGGTKDVPVGQL 151
            |||||||.|:||.|.||||:.:..||.|||||||||.:..|:.|:|.||:||:|.|::.|.:|.|
Zfish    69 ALSPTMEEGNIVKWLKKEGEDVAAGDALCEIETDKAVVVMESNEDGVLARILVQEGSRGVRLGTL 133

  Fly   152 LCIIVPDQGSVAAFANFKDDGAAAAPAAPAAAPAPAPAAAAAPPPPPPPAAAPAAAAPPPAPAAA 216
            :.::|.:.         :|......||..:..|   |.||      ||.||.|.|.:.|||..|.
Zfish   134 IALMVSEG---------EDWKQVEIPALESVTP---PTAA------PPTAAPPTAGSAPPAAPAL 180

  Fly   217 PAAAGTGRVYASPMAKRLAEAQQL-RLQGKGSGVHGSIKSGD---LAGQKAAAKPAAAAPAKA-- 275
            ..:..|..:..||.|:.:.:...| ..|...||..|.|...|   |..:.:||.|||||||.:
Zfish   181 RQSVPTPLLRLSPAARHILDTHGLDPHQATASGPRGIITKEDALKLLSKASAAPPAAAAPAPSAP 245

  Fly   276 ------------PRAAGAR------YEDIPVTNMRAVIAKRLLESKTQLPHYYVTVQCQVDKLLK 322
                        |.:|.||      :.:||.:::|.:||:||.:|||.:||.|..:.|.:..::
Zfish   246 PAAPPAARPPHPPASAPARSAAPGTFTEIPASSVRRIIAQRLTQSKTTIPHTYACIHCDISGVM- 309

  Fly   323 FRAKVNKKYEKQGARVSVNDFIIKAVAIASLKVPEANSAWMDTVIRKYDDVDVSVAVSTDKGLIT 387
               :|.|:..::..:||||||||||.|::..::|..|.:|.....:....:.:|:||:||:||||
Zfish   310 ---RVRKRLAEENIKVSVNDFIIKAAAVSLRELPAVNVSWSADGPQPLGFIHISMAVATDRGLIT 371

  Fly   388 PIVFNADRKGVLEISKDVKALAAKARDNKLQPHEFQGGTISVSNLGMFGVNQFAAVINPPQSCIL 452
            ||:.:|..||:.|||...||||.||||.||.|.|:|||:.|||||||||:::|:|||||||:|||
Zfish   372 PIIRDAADKGLQEISSTAKALAQKARDGKLLPEEYQGGSFSVSNLGMFGISEFSAVINPPQACIL 436

  Fly   453 AIGTTTKQL-VADPDSLKGFKEVNMLTVTLSADHRVVDGAVAARWLQHFRDYMEDPSNMVL 512
            |:|.:..:| ::..|:|   :..:.||||||:|.|:||..:|:|:|:.||..:|.|..|.|
Zfish   437 AVGGSRTELSLSAEDTL---QTQHTLTVTLSSDARLVDDELASRFLETFRSNLERPERMSL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muc	NP_001260196.1	PDHac_trf_mito	83..512	CDD:273567	188/453 (42%)
		lipoyl_domain	83..155	CDD:133458	40/71 (56%)
		2-oxoacid_dh	299..512	CDD:278621	99/213 (46%)
pdhx	NP_956854.2	PDHac_trf_mito	64..494	CDD:273567	188/454 (41%)
		lipoyl_domain	64..137	CDD:133458	40/72 (56%)
		E3_binding	190..222	CDD:280908	9/31 (29%)
		2-oxoacid_dh	287..494	CDD:278621	99/213 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373186at33208
OrthoFinder	1	1.000	-	-		FOG0001572
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820