DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment muc and CG5599

DIOPT Version :9

Sequence 1:	NP_001260196.1	Gene:	muc / 34021	FlyBaseID:	FBgn0283658	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_573000.1	Gene:	CG5599 / 32441	FlyBaseID:	FBgn0030612	Length:	462	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	132/512 - (25%)
Similarity:	240/512 - (46%)	Gaps:	76/512 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ATYVRRSTGNV-VVRALSSQLINSRKLQSIRSKLNTSQSPVTWSYNFARAYANLPEHIRVPLPAL 88
            ||::.|:.... ::|...||....|:...:.|.|:.     |.|:|.    :::.|.||
  Fly     2 ATHLLRNGATCWLLRNCISQRAALRRCLHVTSSLDK-----TVSFNL----SDIGEGIR------ 51

  Fly    89 SPTMERGSIVSWEKKEGDKLNEGDLLCEIETDKATMGFETPEEGFLAKILIQGGTKDVPVGQLLC 153
                 ..::..|..||||.:.:.|.|||:::|||::...:..:|.:.||       ...:.::..
  Fly    52 -----EVTVKEWFVKEGDTVEQFDNLCEVQSDKASVTITSRYDGKITKI-------HHKIDEIAL 104

  Fly   154 IIVPDQGSVAAFANFKDDGAAAAPAAPAAAPAPAPAAAAAPPPPPPPAAAPAAAAPPPAPAAAPA 218
            :..|    :..|....:|......::.:::...:.::|:   ......:|.|:|.|.......|
  Fly   105 VGKP----LLDFDVVNEDEDEPEDSSSSSSSTSSDSSAS---ENEEKQSAEASATPTEGRVIIP- 161

  Fly   219 AAGTGRVYASPMAKRLAEAQQLRL-QGKGSGVHGSIKSGDLAGQKAAAKPAAAAP-----AKAPR 277
                    |:|..:|||:..||.| :...:|.:|.:..||:........|....|     ||.|.
  Fly   162 --------ATPSVRRLAKEHQLDLAKVPATGKNGRVLKGDILEFLGQVPPGTNVPHPTLLAKTPS 218

  Fly   278 AA--GARYEDIPVTNMRAV--IAKRLLESKTQ---LPHYYVTVQCQVDKLLKFRAKVNKKYEKQG 335
            ||  ||....:|...:..:  :.|.:|:|.|:   :||:..:.:..:.:|::||.::....::.|
  Fly   219 AAPSGAASVSVPADRVEVLKGVRKAMLKSMTESLKIPHFAYSDEIDMTQLMQFRNQLQLVAKENG 283

  Fly   336 A-RVSVNDFIIKAVAIASLKVPEANSAW---MDTVIRKYDDVDVSVAVSTDKGLITPIVFNADRK 396
            . :::...|.|||.:||..|.|..||:.   .::::.| ...::|||:.|.:||:.|.:.|...|
  Fly   284 VPKLTFMPFCIKAASIALSKYPIVNSSLDLASESLVFK-GAHNISVAIDTPQGLVVPNIKNCQTK 347

  Fly   397 GVLEISKDVKALAAKARDNKLQPHEFQGGTISVSNLGMFGVNQFAAVINPPQSCILAIGTTTKQL 461
            .::||:||:.||..:.|...|.|.:|..||.|:||:|:.|.......|..||..|.|:|.|.
  Fly   348 TIIEIAKDLNALVERGRTGSLSPADFADGTFSLSNIGVIGGTYTHPCIMAPQVAIGAMGRTK--- 409

  Fly   462 VADP------DSLKGFKEVNMLTVTLSADHRVVDGAVAARWLQHFRDYMEDPSNMVL 512
             |.|      :.:|.:    :::|:.||||||:||...|.:...::.|:|:|:..:|
  Fly   410 -AVPRFNDKDEVVKAY----VMSVSWSADHRVIDGVTMASFSNVWKQYLENPALFLL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muc	NP_001260196.1	PDHac_trf_mito	83..512	CDD:273567	116/451 (26%)
		lipoyl_domain	83..155	CDD:133458	15/71 (21%)
		2-oxoacid_dh	299..512	CDD:278621	69/225 (31%)
CG5599	NP_573000.1	lipoyl_domain	39..109	CDD:133458	21/95 (22%)
		PLN02528	41..462	CDD:215289	121/468 (26%)
		E3_binding	161..194	CDD:280908	12/41 (29%)
		2-oxoacid_dh	248..461	CDD:278621	67/221 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740