DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment muc and dlat

DIOPT Version :9

Sequence 1:	NP_001260196.1	Gene:	muc / 34021	FlyBaseID:	FBgn0283658	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_997832.2	Gene:	dlat / 324201	ZFINID:	ZDB-GENE-030131-2921	Length:	652	Species:	Danio rerio

Alignment Length:	453	Identity:	249/453 - (54%)
Similarity:	324/453 - (71%)	Gaps:	28/453 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 ANLPEHIRVPLPALSPTMERGSIVSWEKKEGDKLNEGDLLCEIETDKATMGFETPEEGFLAKILI 139
            ::.|.|::|.||||||||..|::..||||.|:||:|||||.||||||||:|||..|||:||||:|
Zfish   213 SSYPPHMKVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKIMI 277

  Fly   140 QGGTKDVPVGQLLCIIVPDQGSVAAFANFKDDGAAAAPAAPAAAPAPAPAAAAAPPPPPPPAAAP 204
            ..||:|||:|..|||||..:..::|||::.:.|.||:|     .|||.|.|.      |||||||
Zfish   278 SEGTRDVPLGTPLCIIVEKESDISAFADYVETGVAASP-----PPAPTPVAT------PPPAAAP 331

  Fly   205 AAAAPPPAPA-AAPAAAGTGRVYASPMAKRLAEAQQLRL-QGKGSGVHGSIKSGDL-------AG 260
            ||..|.||.| ||||||..|||:|||:||:||..:.:.: |..|:|..|.:...|:       ..
Zfish   332 AAPIPAPAAAPAAPAAARKGRVFASPLAKKLAAEKGVDITQVTGTGPDGRVTKKDIDSFVPPKLA 396

  Fly   261 QKAAAKPAA------AAPAKAPRAAGARYEDIPVTNMRAVIAKRLLESKTQLPHYYVTVQCQVDK 319
            ..|||.|:|      ||||.|....|. :.|:|::|:|.|||:||::||..:||||:::...:|:
Zfish   397 PAAAAAPSAPTPSPPAAPAYAAVPTGT-FTDVPISNIRKVIAQRLMQSKQTIPHYYLSIDVNMDQ 460

  Fly   320 LLKFRAKVNKKYEKQGARVSVNDFIIKAVAIASLKVPEANSAWMDTVIRKYDDVDVSVAVSTDKG 384
            :|:.|.::|.:.:.:..::|||||||||.|:|.||||||||:|||||||:...|||||||||..|
Zfish   461 VLELRKELNAEVKAENIKLSVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPVG 525

  Fly   385 LITPIVFNADRKGVLEISKDVKALAAKARDNKLQPHEFQGGTISVSNLGMFGVNQFAAVINPPQS 449
            |||||||||..||:..|||||.||||||||.|||||||||||.::|||||:|:..|:|:|||||:
Zfish   526 LITPIVFNAHIKGLANISKDVSALAAKARDGKLQPHEFQGGTFTISNLGMYGIKHFSAIINPPQA 590

  Fly   450 CILAIGTTTKQLVADPDSLKGFKEVNMLTVTLSADHRVVDGAVAARWLQHFRDYMEDPSNMVL 512
            ||||:|.:.|:|: ..|:.|||...||::||||.|||||||||.|:||..||.::|.|..|:|
Zfish   591 CILAVGGSEKRLL-PADNEKGFDVANMMSVTLSCDHRVVDGAVGAQWLAEFRKFLEKPFTMLL 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muc	NP_001260196.1	PDHac_trf_mito	83..512	CDD:273567	246/443 (56%)
		lipoyl_domain	83..155	CDD:133458	49/71 (69%)
		2-oxoacid_dh	299..512	CDD:278621	129/212 (61%)
dlat	NP_997832.2	Transketolase_C	95..>166	CDD:332185
dlat	NP_997832.2	E3_binding	220..652	CDD:332172	246/444 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590654
Domainoid	1	1.000	284	1.000	Domainoid score	I1601
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6814
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1532
OMA	1	1.010	-	-		QHG62888
OrthoDB	1	1.010	-	-		D373186at33208
OrthoFinder	1	1.000	-	-		FOG0001572
OrthoInspector	1	1.000	-	-		oto40152
orthoMCL	1	0.900	-	-		OOG6_101258
Panther	1	1.100	-	-	LDO	PTHR23151
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R863
SonicParanoid	1	1.000	-	-		X2175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800