DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment muc and dlat-2

DIOPT Version :9

Sequence 1:	NP_001260196.1	Gene:	muc / 34021	FlyBaseID:	FBgn0283658	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001255950.1	Gene:	dlat-2 / 178524	WormBaseID:	WBGene00007824	Length:	337	Species:	Caenorhabditis elegans

Alignment Length:	230	Identity:	107/230 - (46%)
Similarity:	144/230 - (62%)	Gaps:	9/230 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 YEDIPVTNMRAVIAKRLLESKTQLPHYYVTVQCQVDKLLKFRAKVNKKYEKQGARVSVNDFIIKA 347
            ::|||::|:||.|||||..||.|:||.|..|..::|.:|..|    :|.:|.|..||:|||||||
Worm   100 HQDIPLSNIRATIAKRLTASKQQIPHEYQGVDVRIDDILALR----QKLKKSGTAVSLNDFIIKA 160

  Fly   348 VAIASLKVPEANSAWMDTVIRKYDDVDVSVAVSTDKGLITPIVFNADRKGVLEISKDVKALAAKA 412
            .|:|...||..|..|....| ....||:||||:|..|||||||.|:|..|||.||..||.|:..|
Worm   161 AALALRSVPTVNVRWTPEGI-GLGSVDISVAVATPTGLITPIVENSDILGVLAISSKVKELSGLA 224

  Fly   413 RDNKLQPHEFQGGTISVSNLGMFG-VNQFAAVINPPQSCILAIGTTTKQLVADPDSLKGFKEVNM 476
            |::||:|.:||||:.::||||||| |..|.|:|||||..||.||.|..::|:....|:..|   :
Worm   225 RESKLKPQQFQGGSFTISNLGMFGSVTNFTAIINPPQCAILTIGGTRSEVVSVDGQLETQK---L 286

  Fly   477 LTVTLSADHRVVDGAVAARWLQHFRDYMEDPSNMV 511
            :.|.|..|.|.:....|.|:|.||.:.:.||..::
Worm   287 MGVNLCFDGRAISEECAKRFLLHFSESLSDPELLI 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
muc	NP_001260196.1	PDHac_trf_mito	83..512	CDD:273567	107/230 (47%)
		lipoyl_domain	83..155	CDD:133458
		2-oxoacid_dh	299..512	CDD:278621	97/214 (45%)
dlat-2	NP_001255950.1	E3_binding	23..54	CDD:376939
dlat-2	NP_001255950.1	2-oxoacid_dh	98..321	CDD:365941	107/228 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373186at33208
OrthoFinder	1	1.000	-	-		FOG0001572
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23151
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020