DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15818 and CLEC4A

DIOPT Version :9

Sequence 1:	NP_609116.1	Gene:	CG15818 / 34019	FlyBaseID:	FBgn0031910	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_057268.1	Gene:	CLEC4A / 50856	HGNCID:	13257	Length:	237	Species:	Homo sapiens

Alignment Length:	133	Identity:	27/133 - (20%)
Similarity:	60/133 - (45%)	Gaps:	18/133 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 QKRTENQLTAIQKTLSDIERKLVLQ---------RYQQIGSRYFYIEHNLQVNWRTAEQRCIEMG 188
            :|:|..:|  :..||..:::.:.::         .::...|..::|... ..:|:.:|:.|..|.
Human    77 EKKTTKEL--VHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTE-SASWQDSEKDCARME 138

  Fly   189 GHLAAFQNAEEYNAIVGQLNKAN-YWLGVNDLAKQ--GEFISLASGKRATYFKWRKNEPKYNNPT 250
            .||......||.:.|...|.:.: |::|::|...|  .:::.......::.| |...||  ::|.
Human   139 AHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTF-WHPREP--SDPN 200

  Fly   251 QHC 253
            :.|
Human   201 ERC 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15818	NP_609116.1	CLECT	164..278	CDD:153057	22/93 (24%)
CLEC4A	NP_057268.1	ITIM motif. /evidence=ECO:0000269\|PubMed:20530286	5..10
		CLECT_DC-SIGN_like	106..232	CDD:153060	22/102 (22%)
		Mannose binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	195..197		2/3 (67%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	207..209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11773
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010