DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15818 and CD209

DIOPT Version :9

Sequence 1:	NP_609116.1	Gene:	CG15818 / 34019	FlyBaseID:	FBgn0031910	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_066978.1	Gene:	CD209 / 30835	HGNCID:	1641	Length:	404	Species:	Homo sapiens

Alignment Length:	264	Identity:	60/264 - (22%)
Similarity:	110/264 - (41%)	Gaps:	55/264 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QEGRRYVCLLSDPPNQCSEYCVSALQPVIDHLSKEQQDWGACEVKLNGSVAKLDKIEDQLTATQI 89
            ||..|....:.:.|.:      |.||.:...|:     |....|......:|:.:|..:||
Human   125 QELTRLKAAVGELPEK------SKLQEIYQELT-----WLKAAVGELPEKSKMQEIYQELT---- 174

  Fly    90 QIEAQQAFLVNNISKAIKTEDLEQKLKDIEGNQTALSNQLKDGQKRTE--NQLTAIQKTLSDIER 152
            :::|    .|..:.:..|.:::.|:|..::    |...:|.:..|:.|  .:||.::..:.::..
Human   175 RLKA----AVGELPEKSKQQEIYQELTRLK----AAVGELPEKSKQQEIYQELTRLKAAVGELPE 231

  Fly   153 KLVLQR-YQQI----------------------GSRYFYIEHNLQVNWRTAEQRCIEMGGHLAAF 194
            |...|. ||::                      |:.||.  .|.|.||..:...|.|:|..|...
Human   232 KSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFM--SNSQRNWHDSITACKEVGAQLVVI 294

  Fly   195 QNAEEYNAIVGQLNKAN--YWLGVNDLAKQGEFISLASGKRATYFK--WRKNEPKYNNPTQHCAY 255
            ::|||.|.:..|.:::|  .|:|::||.::|.:..:........||  |.:.||. |...:.||.
Human   295 KSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPN-NVGEEDCAE 358

  Fly   256 VFGH 259
            ..|:
Human   359 FSGN 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15818	NP_609116.1	CLECT	164..278	CDD:153057	30/100 (30%)
CD209	NP_066978.1	Endocytosis signal	14..15
		Endocytosis signal. /evidence=ECO:0000255	16..18
		Endocytosis signal. /evidence=ECO:0000255	31..34
		transmembrane domain	36..59
		PilO	38..>184	CDD:294757	16/77 (21%)
		neck domain	60..249		29/146 (20%)
		CLECT_DC-SIGN_like	256..379	CDD:153060	31/110 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X59
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010