DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gudu and Odad2

DIOPT Version :9

Sequence 1:	NP_609111.1	Gene:	gudu / 34014	FlyBaseID:	FBgn0031905	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001344421.1	Gene:	Odad2 / 74934	MGIID:	1922184	Length:	1037	Species:	Mus musculus

Alignment Length:	660	Identity:	293/660 - (44%)
Similarity:	434/660 - (65%)	Gaps:	23/660 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IGTSSGTSHNRSRKKKEQCGSCPNRFSKDKRQVAAEDSDTTEVESSTDEEERWKEVARAAEIPAD 66
            :..|...||.:..:|.|              :..:|.|.    ||..|||.........|::|::
Mouse   397 VAPSRAQSHRKGGEKVE--------------ETVSESSS----ESEEDEEPPDHRQEANADLPSE 443

  Fly    67 YYNIQKLVKYIKAGNQTATIVSLCCLKDYDLSTQINQFAISDIGGLDVLVNILECSDTKCCLGAL 131
            |:.|||||||:|.||||||:::||.::|::|:.:..|.||.|:|||:||:|:|:..:.||.:|:|
Mouse   444 YWQIQKLVKYLKGGNQTATVIALCSMRDFNLAQETCQLAIRDVGGLEVLINLLDTDEVKCKIGSL 508

  Fly   132 KVLSDITLNIDIRKTIVDLDGIPLIVDILNSSMKDLKTMAAETLANVCKVRLARKYVRTCGGIPK 196
            |:|.:|:.|..||:.||||.|:|::|:||:|..|.||.::|||:|||.|.:.||:.||..|||.|
Mouse   509 KILKEISHNPQIRRNIVDLGGLPIMVNILDSPHKSLKCLSAETIANVAKFKRARRAVRQHGGITK 573

  Fly   197 LVDLIDIKLSILKTPRDQLSPDDLESLDMTRAGARALFTLADSKHNMEQMRKSGIVPLMAQLLKS 261
            ||.|:|...:  .|...|.|..:...:::.|.||.||::.:.|..|.|.:||:|.:||:|:|||:
Mouse   574 LVALLDCGQN--STEPTQPSLYETRDVEVARCGALALWSCSKSHSNKEAIRKAGGIPLLARLLKT 636

  Fly   262 CHIDVVIPIMGTVRKCSSEPKFQLAITTEGMIPDIVSHLSSENTELKMEGSTAIYKCAFDGTTRD 326
            .|.:::||::||:::|:||..::.||..|.:|.::|.:|:|||.:|:...:.|||:||.|..|||
Mouse   637 SHENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDEETRD 701

  Fly   327 LVREAGGLEPLVTIIKDKNVRENKPLLRGATGAIWMCAVTDANVKVLDQLRTVNHLVALLNDECD 391
            |||..|||:||.:::   |..:||..|...|||||.|:::..||....:.:.:..||.||.|:.:
Mouse   702 LVRLHGGLKPLASLL---NNTDNKERLAAVTGAIWKCSISKENVIKFREYKAIETLVGLLTDQPE 763

  Fly   392 EVLTNVTGAISECVRFQSNREQLRQAGGLPAMVSLLNSSHAPLLENLAKGLKECAEDPDSMRILE 456
            |||.||.||:.||.:...||..:|:.||:..:|:||...:..||.|:.|.:..||.:|:||.|::
Mouse   764 EVLVNVVGALGECCQEYENRVLVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMAIID 828

  Fly   457 DLDAVRLIWSLLKNPTTRVQAHAAYAICPCVRNANDSAELVRSLVGAMELVVGLLKSKDIMVLSA 521
            .||.|||:|||||||...|:|.||:|:|||:.||.|:.|:|||.||.:||||.||||.:..||::
Mouse   829 RLDGVRLLWSLLKNPHPDVKASAAWALCPCIENAKDAGEMVRSFVGGLELVVNLLKSDNKEVLAS 893

  Fly   522 VCAAIATIAQDQTNLAILTDLKVIYKLADLVQTTDDLLRMNLAAAVAACACFGNNTEELGRLRTV 586
            |||||..||:||.|||::||..|:..|:.|..|.:|.||.:||.|::.|..:|.|....|..:.|
Mouse   894 VCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNDKLRRHLAEAISRCCMWGRNRVAFGEHKAV 958

  Fly   587 TPIVTYMTSDNPLVHRSTAMALEKLSMDPQNCITMHQSGVVPFLLECIGSTNKELQLAAAGCLRN 651
            .|:|.|:.|::..|||:||.||.:||.|..||||||::|.|..||:.:||.:::||.|||||:.|
Mouse   959 APLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISN 1023

  Fly   652 IRELALRAEE 661
            ||.|||..|:
Mouse  1024 IRRLALATEK 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gudu	NP_609111.1	armadillo repeat	105..134	CDD:293788	15/28 (54%)
		armadillo repeat	144..180	CDD:293788	20/35 (57%)
		Arm_3	214..557	CDD:330530	155/342 (45%)
		armadillo repeat	245..275	CDD:293788	14/29 (48%)
		armadillo repeat	286..318	CDD:293788	13/31 (42%)
		armadillo repeat	328..362	CDD:293788	15/33 (45%)
		armadillo repeat	411..447	CDD:293788	12/35 (34%)
		armadillo repeat	453..484	CDD:293788	18/30 (60%)
		armadillo repeat	494..526	CDD:293788	19/31 (61%)
		ARM	614..652	CDD:214547	20/37 (54%)
		armadillo repeat	619..652	CDD:293788	17/32 (53%)
Odad2	NP_001344421.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..439		12/59 (20%)
		armadillo repeat	447..472	CDD:293788	16/24 (67%)
		ARM 1. /evidence=ECO:0000255	477..516		18/38 (47%)
		armadillo repeat	482..514	CDD:293788	16/31 (52%)
		ARM 2. /evidence=ECO:0000255	518..557		21/38 (55%)
		armadillo repeat	521..557	CDD:293788	20/35 (57%)
		armadillo repeat	564..610	CDD:293788	18/47 (38%)
		ARM 3. /evidence=ECO:0000255	615..654		17/38 (45%)
		PLN03200	<618..>855	CDD:215629	105/239 (44%)
		armadillo repeat	620..652	CDD:293788	14/31 (45%)
		ARM 4. /evidence=ECO:0000255	656..695		14/38 (37%)
		armadillo repeat	658..695	CDD:293788	14/36 (39%)
		armadillo repeat	700..733	CDD:293788	17/35 (49%)
		ARM 5. /evidence=ECO:0000255	739..778		16/38 (42%)
		armadillo repeat	742..778	CDD:293788	15/35 (43%)
		SRP1	<750..1035	CDD:227396	140/284 (49%)
		ARM 6. /evidence=ECO:0000255	821..860		24/38 (63%)
		armadillo repeat	823..860	CDD:293788	23/36 (64%)
		ARM 7. /evidence=ECO:0000255	864..903		23/38 (61%)
		armadillo repeat	876..901	CDD:293788	15/24 (63%)
		ARM 8. /evidence=ECO:0000255	905..944		17/38 (45%)
		armadillo repeat	908..985	CDD:293788	31/76 (41%)
		HEAT repeat	919..947	CDD:293787	10/27 (37%)
		ARM 9. /evidence=ECO:0000255	946..985		16/38 (42%)
		ARM 10. /evidence=ECO:0000255	987..1026		21/38 (55%)
		armadillo repeat	991..1024	CDD:293788	17/32 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0167
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9992
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1116
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52924
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006010
OrthoInspector	1	1.000	-	-		oto92341
orthoMCL	1	0.900	-	-		OOG6_105842
Panther	1	1.100	-	-	LDO	PTHR46241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X4308
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790