DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gudu and Rsph14

DIOPT Version :9

Sequence 1:	NP_609111.1	Gene:	gudu / 34014	FlyBaseID:	FBgn0031905	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001157005.1	Gene:	Rsph14 / 71236	MGIID:	1918486	Length:	374	Species:	Mus musculus

Alignment Length:	388	Identity:	76/388 - (19%)
Similarity:	144/388 - (37%)	Gaps:	98/388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 TKCCLG-ALKVLSDITLNIDIRKTIVDLDGIPLIVDILN-----------SSMKDLKTMAAETLA 176
            ||..:. ..:.||.:...:..|..:.....:..:.|:::           ..::.|||:..:. .
Mouse    50 TKAAIAYGCRALSKLNEELQSRDLLTRQKALVALCDLMHDPEYVYEAINIGCLESLKTLLQDD-D 113

  Fly   177 NVCKVR-------LARKYVRTCGGIPKLVDLIDIKLSILKTPRDQLSPDDLESLDMTRAGARALF 234
            |:.:::       :|..||...|.:..  |:|. .||:|.:....|..::|.         :|..
Mouse   114 NLVRIKTTEVLYIMATHYVGRVGFLKH--DIIQ-ALSLLLSDHQTLCRENLH---------QAYK 166

  Fly   235 TLADSKHNMEQMRKSGIVPLMAQLL--KSCHIDVVIPIMGTVRKCSSEPKFQLAITTEGM----I 293
            .||......:.:.:||::|.:.:.|  :..||..:  |:.|:..|..|.      .||.:    :
Mouse   167 HLAQLPKGAQGIVQSGLIPSLVRKLQKEEDHIQEI--ILDTLALCLQED------ATEALESQAV 223

  Fly   294 PDIVSHLSSENTELKMEGSTAIYKCA--FDGTTRDLVREAGGLEPLVTIIKDKNVRENKPLLRGA 356
            |.:...|.|:|:|::.:.:.|:...:  .||                     ||
Mouse   224 PCLKEKLLSQNSEIRSKAARALIAISIPLDG---------------------KN----------- 256

  Fly   357 TGAIWMCAVTDANVKVLDQLRTVNHLVALLNDECDEVLTNVTGAISECVRFQSNREQLRQAGGLP 421
              .:|             :.:.:..||.||:|..:||..|..||:.........:.....|..:.
Mouse   257 --QVW-------------KNKVIPILVTLLSDTDEEVKANAAGALMHATVTTEGKYAALDANAIE 306

  Fly   422 AMVSLLNSS-HAPLLENLAKGLKECAEDPDSMRILEDLDAVRLIWSLLKNPTTRVQAHAAYAI 483
            .::.||::: ...|..|..|.|...||.|:..::|  |..|.:...||.:....:|..|..||
Mouse   307 PLLELLSTNPKTKLCLNATKALTMLAEAPEGRKLL--LSHVPIFRYLLAHKNEAIQRAAEVAI 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gudu	NP_609111.1	armadillo repeat	105..134	CDD:293788	2/10 (20%)
		armadillo repeat	144..180	CDD:293788	6/46 (13%)
		Arm_3	214..557	CDD:330530	57/279 (20%)
		armadillo repeat	245..275	CDD:293788	8/31 (26%)
		armadillo repeat	286..318	CDD:293788	8/35 (23%)
		armadillo repeat	328..362	CDD:293788	2/33 (6%)
		armadillo repeat	411..447	CDD:293788	7/36 (19%)
		armadillo repeat	453..484	CDD:293788	9/31 (29%)
		armadillo repeat	494..526	CDD:293788
		ARM	614..652	CDD:214547
		armadillo repeat	619..652	CDD:293788
Rsph14	NP_001157005.1	HEAT repeat	102..126	CDD:293787	4/24 (17%)
		HEAT repeat	142..170	CDD:293787	8/37 (22%)
		ARM	176..286	CDD:237987	32/164 (20%)
		HEAT_2	184..287	CDD:290374	31/157 (20%)
		HEAT repeat	184..208	CDD:293787	6/25 (24%)
		armadillo repeat	223..248	CDD:293788	6/24 (25%)
		armadillo repeat	255..290	CDD:293788	13/60 (22%)
		ARM	257..370	CDD:237987	30/126 (24%)
		armadillo repeat	296..328	CDD:293788	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0167
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900