DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gudu and armc3

DIOPT Version :9

Sequence 1:	NP_609111.1	Gene:	gudu / 34014	FlyBaseID:	FBgn0031905	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_688618.3	Gene:	armc3 / 560136	ZFINID:	ZDB-GENE-110614-1	Length:	831	Species:	Danio rerio

Alignment Length:	632	Identity:	144/632 - (22%)
Similarity:	262/632 - (41%)	Gaps:	91/632 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKKKEQCGSCPNRFSKDKRQVAAEDSDTTEVESSTDEEERWKEVARAAEIPADYYNIQKLVKYIK 78
            :|.|::..:||.... |...:.::.:.|..:..|:.|||   .:|:|.|         .:.|:.:
Zfish     3 KKVKKEAETCPKDVF-DPLSIESKTATTAVLMLSSPEEE---VLAKACE---------AIHKFAE 54

  Fly    79 AGNQTATIVSLCCLKDYDLSTQINQFAISDIGGLDVLVNILECSDTKCCLGALKVLSDITLNIDI 143
            .|::..|  .|.||                 |.::.|..::...|......|:..|..:..|.::
Zfish    55 KGDENKT--CLMCL-----------------GAIEPLSLLISHEDKIVRRNAVMALGVMASNNEV 100

  Fly   144 RKTIVDLDGIPLIVDILNSSMKDLKTMAAETLANVCKVRLARKY-----VRTCGGIPKLVDLIDI 203
            :|.:..||.||.|:    |.:...:.:.....|.:|...|:..:     :....|:..|:.|:.
Zfish   101 KKHLKCLDVIPAII----SKLSPEENVMVHEFATLCLASLSVDFSYKIQIFESNGLEPLIQLLS- 160

  Fly   204 KLSILKTPRDQLSPDDLESLDMTRAGARALFTLADSKHNMEQMRKSGIVPLMAQLLKSCHIDVVI 268
                        |||.    |:.:.....:|.|.....|...:::...:|.:..||:| ...|:.
Zfish   161 ------------SPDP----DVKKNSVECIFNLVQDVQNRAAVQRLNGLPPLLDLLRS-EFSVIQ 208

  Fly   269 PI-MGTVRKCSSEPKFQLAI-TTEGM--IPDIVSHLSSENTELKMEGSTAIYKCAFDGTTRDLVR 329
            .: :.|:.|.:::.:..:|. ..:|.  |.::|:  ..|.::|.......|..|..|..:..|.:
Zfish   209 QLALHTIEKITTDTETCVAFRNVQGFERILEVVA--MKEFSDLHEGALRVILNCLEDTESMQLFQ 271

  Fly   330 EAGGLEPLVTIIKDKNVRENKPLLRGATGAIWMCAVTDANVKVLDQLRTVNHLVALLNDECDEVL 394
            ..||||.|:..:....|.|.|   ..|..||...|.:..|.|:|.:......|..||..|.:.|.
Zfish   272 TMGGLEQLLQCVGTSTVAEVK---ANAVKAIAKMAQSSENRKILHERNIEKTLTDLLTQENESVR 333

  Fly   395 TNVTGAISECVRFQSNREQLRQAGGLPAMVSLLNSSHAPLLENLAKGLKECAEDPD-SMRILEDL 458
            |.|..|::...:..|:|:..|...|:..:|.||||..:.|....|:.|.......: :...:.|.
Zfish   334 TAVCQAVATVSKNLSSRDTFRSLDGIRPIVQLLNSEGSELRMAAAEALSSLTNSNNLNAYAIYDA 398

  Fly   459 DAVRLIWSLLKNPTTRVQAHAAYAICPCVRNANDSAELVRSLVG--AMELVVGLLKSKDIMVLSA 521
            :..||:...|::..|....:||.|:    .|.....||.:|::.  ||..:|.||.|.|..:|.:
Zfish   399 EGDRLLVRQLQDSCTGAAVYAAMAL----TNMASQEELRKSILAHEAMPALVELLHSTDNNILIS 459

  Fly   522 VCAAIATIAQDQTNLAILTDLKVIYKLADLVQTTDDLLRMNLAAAVAACACFGNNTEEL---GRL 583
            ...|:|::..|......|.::..:..|..|:::.:..:|.|.:.|::.||.......||   |.|
Zfish   460 AVQAVASLTCDAEARQELRNVGGLSALVQLLKSINAEIRRNASWAISVCANDEITASELCNVGAL 524

  Fly   584 RTVTPIVTYMTSDNPLVHRS---TAMALEKL---SMDPQNCITMHQS 624
            ..:..|  .::|     |||   :.:||:||   ::..:..:|.|.|
Zfish   525 EILQEI--SLSS-----HRSNKFSQLALQKLLDSNLSLKYSLTGHLS 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gudu	NP_609111.1	armadillo repeat	105..134	CDD:293788	4/28 (14%)
		armadillo repeat	144..180	CDD:293788	8/35 (23%)
		Arm_3	214..557	CDD:330530	85/349 (24%)
		armadillo repeat	245..275	CDD:293788	6/30 (20%)
		armadillo repeat	286..318	CDD:293788	7/34 (21%)
		armadillo repeat	328..362	CDD:293788	11/33 (33%)
		armadillo repeat	411..447	CDD:293788	11/35 (31%)
		armadillo repeat	453..484	CDD:293788	8/30 (27%)
		armadillo repeat	494..526	CDD:293788	11/33 (33%)
		ARM	614..652	CDD:214547	3/11 (27%)
		armadillo repeat	619..652	CDD:293788	3/6 (50%)
armc3	XP_688618.3	ARM	31..179	CDD:237987	38/199 (19%)
		armadillo repeat	60..96	CDD:293788	9/54 (17%)
		ARM	108..220	CDD:237987	25/133 (19%)
		armadillo repeat	110..136	CDD:293788	6/29 (21%)
		armadillo repeat	144..179	CDD:293788	9/51 (18%)
		armadillo repeat	184..218	CDD:293788	6/34 (18%)
		ARM	268..385	CDD:237987	36/119 (30%)
		HEAT_2	276..382	CDD:290374	32/108 (30%)
		HEAT repeat	276..301	CDD:293787	9/27 (33%)
		HEAT repeat	317..345	CDD:293787	8/27 (30%)
		HEAT repeat	355..387	CDD:293787	9/31 (29%)
		ARM	394..506	CDD:237987	29/115 (25%)
		armadillo repeat	433..469	CDD:293788	11/35 (31%)
		armadillo repeat	474..506	CDD:293788	6/31 (19%)
		ARM	475..>554	CDD:237987	21/85 (25%)
		EDR1	553..817	CDD:291079	3/12 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0167
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840