DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gudu and ODAD2

DIOPT Version :9

Sequence 1:	NP_609111.1	Gene:	gudu / 34014	FlyBaseID:	FBgn0031905	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_024303817.1	Gene:	ODAD2 / 55130	HGNCID:	25583	Length:	1107	Species:	Homo sapiens

Alignment Length:	716	Identity:	293/716 - (40%)
Similarity:	438/716 - (61%)	Gaps:	80/716 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SHNRSRKKKEQCGSCPNRFSKDKRQVAAEDSDTTEVESSTDEEERWKEVARAAEIPADYYNIQKL 73
            ||.|::..::         |.:|.:....||.:   ||..|||........:|::|::|:.||||
Human   405 SHGRAQLLRK---------SAEKIEETVSDSSS---ESEEDEEPPDHRQEASADLPSEYWQIQKL 457

  Fly    74 VKYIKAGNQTATIVSLCCLKDYDLSTQINQFAISDIGGLDVLVNILECSDTKCCLGALKVLSDIT 138
            |||:|.||||||:::||.::|:.|:.:..|.||.|:|||:||:|:||..:.||.:|:||:|.:|:
Human   458 VKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEIS 522

  Fly   139 LNIDIRKTIVDLDGIPLIVDILNSSMKDLKTMAAETLANVCKVRLARKYVRTCGGIPKLVDLIDI 203
            .|..||:.||||.|:|::|:||:|..|.||.:||||:|||.|.:.||:.||..|||.|||.|:|.
Human   523 HNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFKRARRVVRQHGGITKLVALLDC 587

  Fly   204 KLSILKTPRDQLSPDDLESLDMTRAGARALFTLADSKHNMEQMRKSGIVPLMAQLLKSCHIDVVI 268
            .....|..:..|.  :...:::.|.||.||::.:.|..|.|.:||:|.:||:|:|||:.|.:::|
Human   588 AHDSTKPAQSSLY--EARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHENMLI 650

  Fly   269 PIMGTVRKCSSEPKFQLAITTEGMIPDIVSHLSSENTELKMEGSTAIYKCAFDGTTRDLVREAGG 333
            |::||:::|:||..::.||..|.:|.::|.:|:|||.:|:...:.|||:||.|..||||||..||
Human   651 PVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGG 715

  Fly   334 LEPLVTIIKDKNVRENKPLLRGATGAIWMCAVTDANVKVLDQLRTVNHLVALLNDECDEVLTNVT 398
            |:||.:::   |..:||..|...|||||.|:::..||....:.:.:..||.||.|:.:|||.||.
Human   716 LKPLASLL---NNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVV 777

  Fly   399 GAISECVRFQSNREQLRQAGGLPAMVSLLNSSHAPLLENLAKGLKECAEDPDSM----------- 452
            ||:.||.:.:.||..:|:.||:..:|:||...:..||.|:.|.:..||.:|:||
Human   778 GALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMWGLTLSSRLK 842

  Fly   453 --------------------------------RILEDLDAVRLIWSLLKNPTTRVQAHAAYAICP 485
                                            ||::.||.|||:|||||||...|:|.||:|:||
Human   843 YSGMMRGHCSLKLLGSSDPPNFVFFRSRKLRNRIIDRLDGVRLLWSLLKNPHPDVKASAAWALCP 907

  Fly   486 CVRNANDSAELVRSLVGAMELVVGLLKSKDIMVLSAVCAAIATIAQDQTNLAILTDLKVIYKLAD 550
            |::||.|:.|:|||.||.:||:|.||||.:..||::|||||..||:||.|||::||..|:..|:.
Human   908 CIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVPLLSK 972

  Fly   551 LVQTTDDLLRMNLAAAVAACACFGNNTEELGRLRTVTPIVTYMTSDNPLVHRSTAMALEKLSMDP 615
            |..|.::.||.:||.|::.|..:|.|....|..:.|.|:|.|:.|::..|||:||.||.:||.|.
Human   973 LANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDA 1037

  Fly   616 QNCITMHQSGVVP--------------------FLLECIGSTNKELQLAAAGCLRNIRELALRAE 660
            .||||||::|.|.                    .||:.:||.:::||.|||||:.|||.|||..|
Human  1038 DNCITMHENGAVKATQREDDEDEDLYDDPLPLNLLLDMVGSPDQDLQEAAAGCISNIRRLALATE 1102

  Fly   661 E 661
            :
Human  1103 K 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gudu	NP_609111.1	armadillo repeat	105..134	CDD:293788	16/28 (57%)
		armadillo repeat	144..180	CDD:293788	21/35 (60%)
		Arm_3	214..557	CDD:330530	154/385 (40%)
		armadillo repeat	245..275	CDD:293788	14/29 (48%)
		armadillo repeat	286..318	CDD:293788	13/31 (42%)
		armadillo repeat	328..362	CDD:293788	15/33 (45%)
		armadillo repeat	411..447	CDD:293788	12/35 (34%)
		armadillo repeat	453..484	CDD:293788	19/30 (63%)
		armadillo repeat	494..526	CDD:293788	18/31 (58%)
		ARM	614..652	CDD:214547	20/57 (35%)
		armadillo repeat	619..652	CDD:293788	17/52 (33%)
ODAD2	XP_024303817.1	PLN03200	<449..684	CDD:331927	107/236 (45%)
		armadillo repeat	454..479	CDD:293788	16/24 (67%)
		armadillo repeat	489..521	CDD:293788	17/31 (55%)
		armadillo repeat	528..564	CDD:293788	21/35 (60%)
		armadillo repeat	571..617	CDD:293788	17/47 (36%)
		PLN03200	<625..>823	CDD:331927	83/200 (42%)
		armadillo repeat	627..659	CDD:293788	14/31 (45%)
		armadillo repeat	665..702	CDD:293788	14/36 (39%)
		armadillo repeat	710..741	CDD:293788	15/33 (45%)
		armadillo repeat	749..785	CDD:293788	15/35 (43%)
		armadillo repeat	876..908	CDD:293788	19/31 (61%)
		HEAT_2	885..990	CDD:316194	57/104 (55%)
		armadillo repeat	926..951	CDD:293788	14/24 (58%)
		armadillo repeat	958..995	CDD:293788	14/36 (39%)
		armadillo repeat	999..1030	CDD:293788	11/30 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146960
Domainoid	1	1.000	292	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E1_KOG0167
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9992
Inparanoid	1	1.050	556	1.000	Inparanoid score	I1110
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52924
OrthoDB	1	1.010	-	-		D185919at33208
OrthoFinder	1	1.000	-	-		FOG0006010
OrthoInspector	1	1.000	-	-		oto88776
orthoMCL	1	0.900	-	-		OOG6_105842
Panther	1	1.100	-	-	LDO	PTHR46241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4308
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770