DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gudu and CG13326

DIOPT Version :9

Sequence 1:	NP_609111.1	Gene:	gudu / 34014	FlyBaseID:	FBgn0031905	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_610838.1	Gene:	CG13326 / 36439	FlyBaseID:	FBgn0033794	Length:	867	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	127/688 - (18%)
Similarity:	258/688 - (37%)	Gaps:	187/688 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DSDTTEVESSTDEEERWKEVARAAEIPADYYNIQKLVKYIKAGNQTATIV----SLCCLKDYDLS 98
            ::.:|..:.:..||:.:.||:    :|     |:||        .||.::    ..|.|  ..:.
  Fly    10 EAKSTYPDRTKSEEKSFTEVS----VP-----IKKL--------DTALLLLSSKEECVL--LTIF 55

  Fly    99 TQINQFAISDIGGLDVLVNILECSDTKCCLGALKVLSDITLNIDIRKTIVDLDGIPLIVDILNSS 163
            :.|..||....      ||:||....:    .|::|.:..|.|....|::....:.|:..:|:::
  Fly    56 SHITDFARRQD------VNVLELKAHR----LLELLLEKDLFIASENTMIRRFALYLLTALLDNT 110

  Fly   164 MKDLKTMAAETLANVCKVRLARKYVRT----CGGIPKLVDLIDIKLSILKTPRDQLSPDDLESLD 224
              |:.|...|....:.:: ..|.|::.    |  |..|..::::   .||.|  |::...:|:.:
  Fly   111 --DMSTYEPEQADQILEL-ACRFYMKEVDDFC--IEYLTYILNV---CLKDP--QMAHGIVEATE 165

  Fly   225 MTRAGARALFTLA-DSKHNMEQMRKSGIVPLMAQLLKSCHIDVVIPIMGTVRKCSSEPKFQLAIT 288
            ....     |.|. .|..|.:.:..|         :::.|..:::.....:...:::|.|.
  Fly   166 FLEK-----FKLVFISSENPDTVFNS---------IEALHRMLLVQSADQMLDFTTQPDFP---- 212

  Fly   289 TEGMIPDIVSHLSSENTELKMEG----------------STAIYKCAFDGTTRDLVR-------- 329
                :..|:..:::|..|::...                ..|:::|.|  ....||:
  Fly   213 ----VDRIICEVTNEFQEIRKAALKTLKTLLADTGDDSVFEALHRCYF--VLEQLVKVFCESPQG 271

  Fly   330 --EAGGLEPLVTIIKDKNVRENKPLLRGATGAIWMCAVTDANV--KVLDQLRTVNHLVALLNDEC 390
              .|..:|.|.|.::.:.:.:               ...:.|:  :|::|:|....|:.|
  Fly   272 PEAADVIEVLATALRSEKMTK---------------LFFEQNLFDQVVEQVRNHMDLMPL----- 316

  Fly   391 DEVLTNVTGAISECVRFQSNREQLRQAGGLPAMVSLLNSSHAPLLENLAKGLKECAEDPDSMRIL 455
             |:...:....:|..:::....::.:|......::.|..:.......:.:||...:..|:::|.:
  Fly   317 -EMRCTIISIFAETAQYEQFLPRMHKAEIADMFLTCLMQNKPAPAAYVIQGLHRMSHHPEALRRI 380

  Fly   456 ---EDLDAVRLIWSLLKNPTTRVQAHAAYAICPCVRNANDSAE-LVRSLVGAMELVVGLLKSKDI 516
               ....|:|.:.::|.:|...::|.            ..:.| |.|.||.|.......|:.:||
  Fly   381 VAAYQEGAIRKLVAILMSPDVAIKAR------------EQAGEFLSRLLVAAFRETAAQLQEQDI 433

  Fly   517 -MVLSAVCAAIATIAQDQTNLA---ILTDLKVIYKLA-------------DLVQTTDDLLRMNLA 564
             :||:||      |||.|..|:   ||..|.:|..||             .|.:....||..:.|
  Fly   434 AVVLTAV------IAQGQPTLSIDLILLLLTIIESLAQKEEYRTILGEYSSLTEQLAQLLMRSFA 492

  Fly   565 AAVAA-----CACFGNNTEELGRLRTVTPIVTYMTSDNPLVHRSTAMALEKLSMDPQNCITMHQS 624
            .::..     |.|  ...:|.....|:  :..|:.|       |...||:.||       .:.::
  Fly   493 HSILVNNIFRCLC--TLIDEAPVRETL--LANYIVS-------SMKRALKSLS-------NLVKT 539

  Fly   625 GVVPFLLECIGSTNKELQLAAAGCLRNIRELALRAEEY 662
            .|..|:|:    |.:..:...|...|.|.|:.|..:::
  Fly   540 SVTNFILQ----TTRFNEFIDAYIDRGIMEVLLDFQKH 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gudu	NP_609111.1	armadillo repeat	105..134	CDD:293788	6/28 (21%)
		armadillo repeat	144..180	CDD:293788	6/35 (17%)
		Arm_3	214..557	CDD:330530	66/392 (17%)
		armadillo repeat	245..275	CDD:293788	2/29 (7%)
		armadillo repeat	286..318	CDD:293788	4/47 (9%)
		armadillo repeat	328..362	CDD:293788	5/43 (12%)
		armadillo repeat	411..447	CDD:293788	4/35 (11%)
		armadillo repeat	453..484	CDD:293788	6/33 (18%)
		armadillo repeat	494..526	CDD:293788	13/33 (39%)
		ARM	614..652	CDD:214547	6/37 (16%)
		armadillo repeat	619..652	CDD:293788	6/32 (19%)
CG13326	NP_610838.1	EDR1	<759..799	CDD:291079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0167
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840