DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gudu and Ctnnd2

DIOPT Version :9

Sequence 1:	NP_609111.1	Gene:	gudu / 34014	FlyBaseID:	FBgn0031905	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_032755.2	Gene:	Ctnnd2 / 18163	MGIID:	1195966	Length:	1246	Species:	Mus musculus

Alignment Length:	560	Identity:	113/560 - (20%)
Similarity:	201/560 - (35%)	Gaps:	206/560 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 IPLIVDILNSSMKDLKTMAAETLANVC----KVRLARKYVRTCGGIPKLVDLIDIKLSILKTPRD 213
            :|.::.:|......:::.||..|.::|    |::..   :|..|||..||||:|.:::
Mouse   548 LPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAE---IRRQGGIQLLVDLLDHRMT------- 602

  Fly   214 QLSPDDLESLDMTRAGARALFTLADSKHNMEQ---MRKSGIVPLMAQLL-KSCHIDV---VIPIM 271
                      ::.|:...||..|...|.|.:.   ::..|.:|.:.:|| |:..:::   |..::
Mouse   603 ----------EVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVL 657

  Fly   272 GTVRKCSS--EPKFQ--LAITTEGMIPDIVSHLSSENTELKMEGSTAIYKCAFDGTTRDLVREAG 332
            ..:..|.:  .|..|  ||:.|..:   |:.|...||:.|:.:....::       :..::|.|.
Mouse   658 WNLSSCDALKMPIIQDALAVLTNAV---IIPHSGWENSPLQDDRKIQLH-------SSQVLRNAT 712

  Fly   333 GLEPLVTIIKDKNV----RENKPLLRGATGAIWMCAVTDANVKVLDQL--------RTVNHLVAL 385
            |..        :||    .|.:..:|...|      :|||.:.|:...        :||.:.|.:
Mouse   713 GCL--------RNVSSAGEEARRRMRECDG------LTDALLYVIQSALGSSEIDSKTVENCVCI 763

  Fly   386 L------------------NDECDEVL--------TNVTGAISECVRFQSNREQLRQAGGLPAMV 424
            |                  .||.|.:|        |..:|...:..:.:.:::|....|.||
Mouse   764 LRNLSYRLAAETSQGQHMGTDELDGLLCGETNGKDTESSGCWGKKKKKKKSQDQWDGVGPLP--- 825

  Fly   425 SLLNSSHAPLLENLAKGLKECAEDPDSMRILEDLDAVRLIWSLL---KNPTT------RVQ---- 476
                               :|||.|..:::|.....|:...:||   .||.|      .:|
Mouse   826 -------------------DCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAA 871

  Fly   477 ----------AHAAYAI------CPC-------VRNANDSAELVRSLVGAMELVVGLLKSKDIMV 518
                      |..|||:      .||       :|.|      ||...| :.::|.||:..:..|
Mouse   872 GSWKGWAEDVAGMAYALRSLPEGAPCLPQWSVYIRAA------VRKEKG-LPILVELLRIDNDRV 929

  Fly   519 LSAVCAAIATIAQDQTNLAILTDLKVIYKLADLVQTTDDLLRMNLAAAVAACACFGNNTEELGRL 583
            :.||..|:..:|.|..|..::..    |.:.|||.....                |||:...|
Mouse   930 VCAVATALRNMALDVRNKELIGK----YAMRDLVHRLPG----------------GNNSNNSG-- 972

  Fly   584 RTVTPIVTYMTSDNPLVHRSTAMALEKLSMDPQNCITMHQ 623
                   :...||:.:    ||:           |.|:|:
Mouse   973 -------SKAMSDDTV----TAV-----------CCTLHE 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gudu	NP_609111.1	armadillo repeat	105..134	CDD:293788
		armadillo repeat	144..180	CDD:293788	6/30 (20%)
		Arm_3	214..557	CDD:330530	86/427 (20%)
		armadillo repeat	245..275	CDD:293788	6/36 (17%)
		armadillo repeat	286..318	CDD:293788	7/31 (23%)
		armadillo repeat	328..362	CDD:293788	8/37 (22%)
		armadillo repeat	411..447	CDD:293788	5/35 (14%)
		armadillo repeat	453..484	CDD:293788	12/59 (20%)
		armadillo repeat	494..526	CDD:293788	9/31 (29%)
		ARM	614..652	CDD:214547	3/10 (30%)
		armadillo repeat	619..652	CDD:293788	2/5 (40%)
Ctnnd2	NP_032755.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..308
		ARM 1	390..432
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..532
		ARM 2	536..575		5/26 (19%)
		ARM	540..662	CDD:237987	28/133 (21%)
		armadillo repeat	548..573	CDD:293788	5/24 (21%)
		ARM 3	578..617		14/58 (24%)
		armadillo repeat	581..617	CDD:293788	13/55 (24%)
		ARM 4	622..662		6/39 (15%)
		armadillo repeat	625..660	CDD:293788	6/34 (18%)
		armadillo repeat	667..718	CDD:293788	13/68 (19%)
		ARM 5	678..720		11/59 (19%)
		ARM 6	724..769		11/50 (22%)
		ARM 7	831..871		9/39 (23%)
		armadillo repeat	834..871	CDD:293788	8/36 (22%)
		ARM	835..962	CDD:237987	33/137 (24%)
		ARM 8	903..942		12/45 (27%)
		armadillo repeat	906..940	CDD:293788	12/40 (30%)
		ARM	907..1039	CDD:237987	29/135 (21%)
		armadillo repeat	947..993	CDD:293788	15/88 (17%)
		ARM 9	996..1039
		armadillo repeat	999..1034	CDD:293788
		CAF20	<1050..1109	CDD:293657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1063..1130
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940