DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gudu and ankar

DIOPT Version :9

Sequence 1:	NP_609111.1	Gene:	gudu / 34014	FlyBaseID:	FBgn0031905	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_031749763.1	Gene:	ankar / 100496722	XenbaseID:	XB-GENE-1010351	Length:	1400	Species:	Xenopus tropicalis

Alignment Length:	601	Identity:	121/601 - (20%)
Similarity:	241/601 - (40%)	Gaps:	142/601 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 WKEVARAAEIPADYYNIQKLVKYIKAGNQTATIVSLCCLKDYDLSTQINQFAISDIGGLDVLVNI 118
            |:::.:|..||:       ||:.:.:.......::|..|.:...:..::: |:...|.:.|||::
Frog   754 WEDIYKAGTIPS-------LVELLHSDQVPLKCLALGILSNISNNNPVSR-ALVKSGAIQVLVHL 810

  Fly   119 LECS----DTKCCLGALKVLSDITLNIDIRKTIV-DLDGIPLIVDILNSSMKDLKTMAAETLANV 178
            |...    .::|.:    :||||. .||..:.:: ::|||..:|.:|....:|:...|...:..:
Frog   811 LHSRQPELQSRCSV----LLSDIA-QIDSNQNVIAEMDGISPLVHLLYEKYEDVLVNAVNCIRVL 870

  Fly   179 C-KVRLARKYVRTCGGIPKLVDLIDIKLSILKTPRDQLSPDDLESLDMTRAGARALFTLA-DSKH 241
            | |....:|.||..|.||.||:.:..|..||                 ..|....:..|| |:|.
Frog   871 CIKNTANQKAVRDLGAIPSLVEFLTAKSDIL-----------------VSAATDVIAELARDNKA 918

  Fly   242 NMEQMRKSGIVPLMAQLLKSCHIDVVIPIMGTVRK-CSSEPKFQLAITTEGMIPDIVSHLSSENT 305
            ..:.:.|.|::..:..:|:..:|::.:....|:.. |...|..|....|:.:...|...|.....
Frog   919 IQDAVTKEGVIESLISILRVRNINIQVKAAMTIEALCDHNPAVQKEFLTKSVTKHISKLLKVFQL 983

  Fly   306 ELKMEGSTAI-------------------YKCAFDG--TTRDLVREAGGLEPLVTIIKDKNVREN 349
            |::.:|||.:                   |||..|.  :..|.::..|| |.::.:.||..
Frog   984 EVREQGSTTLWALAGQTRKQQKAMAEYIGYKCIIDMLLSPSDKMQYIGG-EAIIALCKDSR---- 1043

  Fly   350 KPLLRGATGAIWMCAVTDAN-----VKVLDQLRTVN-HLVALLNDECDEVLTNVTGAISECVRFQ 408
                      .:.|.:.:.|     |::|...:..| .|:.::         ...|.:...|.|.
Frog  1044 ----------HYQCQICEGNGIGPLVRLLRSPKVANGTLIRII---------KALGIMCIGVAFI 1089

  Fly   409 SN---REQLRQAGGLPAMVSLL---NSSH--APLLENLAKGLKECAEDPDSMRILEDL---DAVR 462
            :|   :|::.:...:|.::.||   ||.|  |.:...||..:...:...||::.:||:   |.:.
Frog  1090 NNPVAQEKIVEENAIPTLLHLLKTQNSLHVKAEVACTLACIVLRNSNLQDSLKEMEDVKYSDILD 1154

  Fly   463 LIW--------------------------SLLKNPTTRV--------------QAHAAYAICPCV 487
            |::                          ::|:|...::              :|.||:.|....
Frog  1155 LLYASDKAICLRAGYALSLFAYSSTMQQFNILENGGIKISIYEPFLQSDIEPERALAAFQIVVLA 1219

  Fly   488 RNANDSAELVRSLVGAMELVVGLLKSKDIMVLSAVCAAIATIAQDQTNL-AILTDLKVIYKLADL 551
            :..:|..::.....| :.::..||:||:...|......:||:|..:|.: ..:|.|..:..|.:.
Frog  1220 KVISDMDQITLCTKG-VTVLTELLQSKNPTTLVLTGELLATLAHIRTGIPEAITTLGTVKCLCNH 1283

  Fly   552 VQTTDDLLRMNLAAAV 567
            :.:.|:.:|:..|.|:
Frog  1284 LYSPDEEVRIACANAL 1299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gudu	NP_609111.1	armadillo repeat	105..134	CDD:293788	7/32 (22%)
		armadillo repeat	144..180	CDD:293788	8/37 (22%)
		Arm_3	214..557	CDD:330530	76/423 (18%)
		armadillo repeat	245..275	CDD:293788	5/29 (17%)
		armadillo repeat	286..318	CDD:293788	8/50 (16%)
		armadillo repeat	328..362	CDD:293788	5/33 (15%)
		armadillo repeat	411..447	CDD:293788	10/40 (25%)
		armadillo repeat	453..484	CDD:293788	9/73 (12%)
		armadillo repeat	494..526	CDD:293788	6/31 (19%)
		ARM	614..652	CDD:214547
		armadillo repeat	619..652	CDD:293788
ankar	XP_031749763.1	ANKYR	<530..641	CDD:223738
		ANK repeat	537..586	CDD:293786
		Ank_2	593..688	CDD:403870
		ANK repeat	621..655	CDD:293786
		ANK repeat	657..688	CDD:293786
		PLN03200	<722..>1011	CDD:215629	61/286 (21%)
		armadillo repeat	722..746	CDD:293788
		armadillo repeat	756..788	CDD:293788	7/38 (18%)
		armadillo repeat	796..831	CDD:293788	11/40 (28%)
		armadillo repeat	836..870	CDD:293788	7/33 (21%)
		armadillo repeat	878..912	CDD:293788	12/50 (24%)
		armadillo repeat	920..954	CDD:293788	5/33 (15%)
		armadillo repeat	962..996	CDD:293788	8/33 (24%)
		armadillo repeat	1014..1038	CDD:293788	7/24 (29%)
		armadillo repeat	1046..1084	CDD:293788	7/46 (15%)
		armadillo repeat	1095..1130	CDD:293788	10/34 (29%)
		armadillo repeat	1185..1218	CDD:293788	6/32 (19%)
		armadillo repeat	1235..1260	CDD:293788	6/24 (25%)
		armadillo repeat	1268..1304	CDD:293788	7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910