DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gudu and jupb

DIOPT Version :9

Sequence 1:	NP_609111.1	Gene:	gudu / 34014	FlyBaseID:	FBgn0031905	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_002665522.2	Gene:	jupb / 100330886	ZFINID:	ZDB-GENE-110407-10	Length:	722	Species:	Danio rerio

Alignment Length:	748	Identity:	162/748 - (21%)
Similarity:	272/748 - (36%)	Gaps:	235/748 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GTSSGTSHNRSRKKKEQCGSCPNRFSKDKRQVAAEDSDTTEVESSTDEEERWKEVARAAEIPADY 67
            |..||.:..|...:           |:.::..|.|.|...|.:.|....:|    .|||..|...
Zfish    27 GIQSGATTIRDEDE-----------SESRKYSAGESSADMEAQFSLTRAQR----VRAAMFPETL 76

  Fly    68 Y----------------NIQKLV---KYIKAGNQTATIVSLCCLKDYDLSTQINQFAISDIGGLD 113
            .                |:|:|.   :.:|    ||.:..:....|.:|:|:    |:.:
Zfish    77 VEGETVLTPQSNPDQPTNVQRLAEPSQLLK----TAIVHLINYQDDAELATR----AVPE----- 128

  Fly   114 VLVNILECSDTKCCLGALKVLSDITLNIDIRKTIVDLDGIPLIVDILNSSMK---DLKT--MAAE 173
             |..:|...|......|..:::.:|.....|:.::.   .|.:|..:..:|:   ||:|  .||.
Zfish   129 -LTKLLADDDQVVVNKAALIVNQLTRKEASRRVLMQ---SPQMVSAVVRAMQNTGDLETARCAAS 189

  Fly   174 TLANVCKVRLARKYVRTCGGIPKLVDLIDIKLSILKTPRDQL---SPDDLESLDMTRAGARALFT 235
            .|.::...|.....:...||||.||       .:|.:|.:.:   :...|.:|.:.:.||:....
Zfish   190 VLHSLSHQREGLLAIFKSGGIPALV-------RMLSSPMESVLFYAITTLHNLLLHQEGAKMAVR 247

  Fly   236 LADSKHNMEQMRKSGIVPLMAQLLKSCHIDVVIPIMGTVRKCSSEPKFQLAITTEGMIPDIVSHL 300
            |||....|        |||:.:                     :.||| |||||     |.:..|
Zfish   248 LADGLQRM--------VPLLKK---------------------TNPKF-LAITT-----DCLQLL 277

  Fly   301 SSENTELKMEGSTAIYKCAFDGTTRDLVREAGGLEPLVTIIKDKNVRE----------------- 348
            |..|.|.|:                 ::...||.|.||.|:::.|..:
Zfish   278 SYGNQESKL-----------------IILANGGPECLVFIMRNYNYEKLLWTTSRVLKVLSVCPS 325

  Fly   349 NKPLLRGATG------------------AIW-MCAVTDANVKV--LDQLRTVNHLVALLNDECDE 392
            |||.:..:.|                  .:| :..::||..|.  ||.|..:  ||:.|..:...
Zfish   326 NKPAIVDSGGMQALGQHLTGSSQRLTQNCLWTLRNLSDAATKQEGLDGLLQI--LVSQLGSDDVN 388

  Fly   393 VLTNVTGAISE--CVRFQSNREQLRQAGGLPAMVSLLNSSHAPLLENLAKGLKECAEDPDSMRIL 455
            :||..||.:|.  |...: |:..:.|:||:.|::      ||.    |..|.||...:|
Zfish   389 MLTCATGILSNLTCNNAR-NKALVTQSGGVEALI------HAV----LRAGEKEDVAEP------ 436

  Fly   456 EDLDAVRLIWSLLKNPTTRVQAHAA---YAICPCVRNANDSAELVRSLVG------AMELVVGLL 511
             .:.|:|.:.|  ::|...:..:|.   |.|           ..:..|:|      .::..|||:
Zfish   437 -AVCALRHLTS--RHPDAELAQNAVRLHYGI-----------PAITKLLGQPHYWPVVKATVGLI 487

  Fly   512 KSKDIMVLSAVCAAIATIAQDQTNLAILTDLKVIYKLADLV---------------QTTDDLLRM 561
            ::      .|:|.|         |.|.|.:...|.:|.:|:               ||..|.:||
Zfish   488 RN------LALCPA---------NQAPLRESGAIPRLVNLLLKAHQETQRHGSGAQQTYQDGVRM 537

  Fly   562 -----NLAAAVAACACFGNNTEELGRLRTVTPIVTYMTSDNPLVHRSTAMALEKLSMDPQNCITM 621
                 ....|:...|....|..|:..::|:...|..:.|....:.|.:|..|.:|::|.|:...:
Zfish   538 EEIVEGCTGALHILARDPMNRGEIASMQTIPLFVQLLYSYVENIKRVSAGVLCELALDKQSAEMI 602

  Fly   622 HQSGVVPFLLECIGSTNKELQLAAAGCLRNIRE 654
            ...|....|:|.:.|.|:.:...||..|..|.|
Zfish   603 DAEGASAPLMELLHSPNEGIATYAAAVLFRISE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gudu	NP_609111.1	armadillo repeat	105..134	CDD:293788	5/28 (18%)
		armadillo repeat	144..180	CDD:293788	10/40 (25%)
		Arm_3	214..557	CDD:330530	87/409 (21%)
		armadillo repeat	245..275	CDD:293788	3/29 (10%)
		armadillo repeat	286..318	CDD:293788	10/31 (32%)
		armadillo repeat	328..362	CDD:293788	12/69 (17%)
		armadillo repeat	411..447	CDD:293788	10/35 (29%)
		armadillo repeat	453..484	CDD:293788	6/33 (18%)
		armadillo repeat	494..526	CDD:293788	7/37 (19%)
		ARM	614..652	CDD:214547	10/37 (27%)
		armadillo repeat	619..652	CDD:293788	8/32 (25%)
jupb	XP_002665522.2	armadillo repeat	126..151	CDD:293788	4/30 (13%)
		armadillo repeat	168..194	CDD:293788	8/25 (32%)
		PLN03200	<186..>457	CDD:331927	80/351 (23%)
		armadillo repeat	203..235	CDD:293788	9/38 (24%)
		ARM	203..235	CDD:214547	9/38 (24%)
		armadillo repeat	243..279	CDD:293788	17/70 (24%)
		armadillo repeat	285..320	CDD:293788	8/51 (16%)
		ARM	323..363	CDD:214547	5/39 (13%)
		armadillo repeat	327..362	CDD:293788	4/34 (12%)
		PLN03200	<374..>639	CDD:331927	71/310 (23%)
		armadillo repeat	375..400	CDD:293788	8/26 (31%)
		armadillo repeat	408..446	CDD:293788	13/54 (24%)
		armadillo repeat	455..490	CDD:293788	8/51 (16%)
		armadillo repeat	497..553	CDD:293788	11/55 (20%)
		armadillo repeat	558..592	CDD:293788	7/33 (21%)
		armadillo repeat	600..633	CDD:293788	8/32 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940