DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5149 and Meak7

DIOPT Version :9

Sequence 1:	NP_609110.1	Gene:	CG5149 / 34013	FlyBaseID:	FBgn0031904	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_083159.1	Gene:	Meak7 / 74347	MGIID:	1921597	Length:	455	Species:	Mus musculus

Alignment Length:	483	Identity:	149/483 - (30%)
Similarity:	238/483 - (49%)	Gaps:	64/483 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNA---SGKRETDNLYNSE--ELRMLESAYKNASGGALEKLTQDRLVETWSQTIERSLAESTAQ 60
            ||||   ||::........|  |:..|.....::.||.   .|....:|.....::.:|..:...
Mouse     1 MGNAKSLSGQKMASRFLPEEQAEVDKLFDVLSSSEGGV---ATGTFSLEAMKSHVKEALPPAMVT 62

  Fly    61 YLFT---PTKPGQQ----CVNLQLKKFGEPYYIMERGTIDQKMQMLLGSMERSGNDTFNSKQLEQ 118
            .|:.   ..||..:    |.::..::|......:.||:.::|..|::..:..:...| .::.:::
Mouse    63 RLYNGMQRVKPTDRTLGSCRSVSREQFTAFLSQLLRGSCEEKGLMVMNMISDAEGPT-KTRDVQK 126

  Fly   119 YIYSVIKSYVHLESTAKNSGIKEWHDLGFNTTERSAA----------------TFAKGLMRNLGK 167
            :...::.|..|:        :...|:|...|..:|..                .|..|......:
Mouse   127 FTEDLVASVAHV--------LTHRHELRGWTCRKSEVPPDSMQAMVAQLLSEMKFQDGYKFQGPQ 183

  Fly   168 ELEHTMPNDALERWLHVTP---QFLQIWREVFSQLYCRHGGS--KRNIIKEMEIPILPALCDAPQ 227
            .|:.......:|.|:...|   .||.:   |..:..|..|.|  ...::.|         |.|.|
Mouse   184 CLDQVCDQAMIEEWVFHVPHVGMFLSV---VVHRGLCLLGSSFDPSTLVPE---------CLADQ 236

  Fly   228 NSHYRPIIELPHVLYINAQLPREHRHKWRFLFSSKINGESFSTMLGKVLDKGPTLFFIEDEDQYI 292
            ...:..|:::..|:|:::.|..|||.:||.|||::::|:|||.:...:..:||:|..:||.|.|:
Mouse   237 GGRFESILDVLSVIYLSSHLAPEHRQRWRLLFSTQLHGQSFSQLCSHITSQGPSLLVLEDRDGYV 301

  Fly   293 FGGYASETWSVKPQFGGDDSSLLYTLSPAMRCFSATTYNNHYQYLNLNQQTMPNGLGMGGQFDFW 357
            |||:||.:|.|||||.||:...|::::|.|.....|.||||:.|||..|||||||||||||..::
Mouse   302 FGGFASCSWEVKPQFQGDNRCFLFSIAPRMATHLHTGYNNHFMYLNYGQQTMPNGLGMGGQHHYF 366

  Fly   358 GLWIDCSFGDGQS--VESCTTYRDYVQLSKRKQFKIRNMEVWAVGDLPVKEEDEEGDGHKRSVLD 420
            |||:...||.|.|  ..:||||.. .|||.::.|....||||.:|:|   .|:.||. :|:||||
Mouse   367 GLWVAADFGKGHSKAKPACTTYNS-PQLSAQEDFLFDKMEVWGLGNL---LEEYEGK-NKKSVLD 426

  Fly   421 GNLEDRAMLEIAGKKMHSDGLREPNMDD 448
            .|.|.|::|||:|:..||:||||...|:
Mouse   427 SNPEARSLLEISGRARHSEGLREVPRDE 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5149	NP_609110.1	DMP12	11..>67	CDD:293384	9/60 (15%)
CG5149	NP_609110.1	TLDc	232..400	CDD:214733	79/169 (47%)
Meak7	NP_083159.1	TLDc	242..410	CDD:214733	79/168 (47%)
Meak7	NP_083159.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	435..455		11/20 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836787
Domainoid	1	1.000	153	1.000	Domainoid score	I4289
eggNOG	1	0.900	-	-		E1_KOG2557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3587
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003986
OrthoInspector	1	1.000	-	-		oto91868
orthoMCL	1	0.900	-	-		OOG6_105332
Panther	1	1.100	-	-	LDO	PTHR23354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3857
SonicParanoid	1	1.000	-	-		X4376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780