DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5149 and MEAK7

DIOPT Version :9

Sequence 1:	NP_609110.1	Gene:	CG5149 / 34013	FlyBaseID:	FBgn0031904	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_065998.3	Gene:	MEAK7 / 57707	HGNCID:	29325	Length:	456	Species:	Homo sapiens

Alignment Length:	477	Identity:	146/477 - (30%)
Similarity:	249/477 - (52%)	Gaps:	50/477 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNASGK--RETDNLYNSEELRMLESAYKNASGGALEKLTQDRLVETWS-QTIERSLAESTAQYL 62
            |||:..:  |...:.:..||...::..:...|.   :|.:.:...:::| :.::..:.|:....:
Human     1 MGNSRSRVGRSFCSQFLPEEQAEIDQLFDALSS---DKNSPNVSSKSFSLKALQNHVGEALPPEM 62

  Fly    63 FTPTKPGQQCVNLQLKKFGEPYYIME-----------RGTIDQKMQMLLGSMERSGNDTFNSKQL 116
            .|....|.:.|:|..|..|....:.:           :|..::|..|:: .|..:......::::
Human    63 VTRLYDGMRRVDLTGKAKGPSENVSQEQFTASMSHLLKGNSEEKSLMIM-KMISATEGPVKAREV 126

  Fly   117 EQYIYSVIKSYVHLESTAKNSGIKEWHDLGFNTTERSAATFAKGLM---------RNLGKE-LEH 171
            :::...::.|.||:.|..:.  ::.|...............|..|:         |.||.: |::
Human   127 QKFTEDLVGSVVHVLSHRQE--LRGWTGKEAPGPNPRVQVLAAQLLSDMKLQDGKRLLGPQWLDY 189

  Fly   172 TMPNDALERWLHVTPQ---FLQIWREVFSQLYCRHGGSKRNIIKEMEIPILPALCDAPQNSHYRP 233
            ......:|.|:...|.   ||.:       :.|:   ....:...:::..|.......|...:..
Human   190 DCDRAVIEDWVFRVPHVAIFLSV-------VICK---GFLILCSSLDLTTLVPERQVDQGRGFES 244

  Fly   234 IIELPHVLYINAQLPREHRHKWRFLFSSKINGESFSTMLGKVLDKGPTLFFIEDEDQYIFGGYAS 298
            |:::..|:|||||||||.||:|..||||:::|.|||.:.|.:..:||.:..:||.|:::|||:||
Human   245 ILDVLSVMYINAQLPREQRHRWCLLFSSELHGHSFSQLCGHITHRGPCVAVLEDHDKHVFGGFAS 309

  Fly   299 ETWSVKPQFGGDDSSLLYTLSPAMRCFSATTYNNHYQYLNLNQQTMPNGLGMGGQFDFWGLWIDC 363
            .:|.|||||.||:...|:::.|:|..::.|.||:||.|||..|||:|||||||||.:::|||:|.
Human   310 CSWEVKPQFQGDNRCFLFSICPSMAVYTHTGYNDHYMYLNHGQQTIPNGLGMGGQHNYFGLWVDV 374

  Fly   364 SFGDGQS--VESCTTYRDYVQLSKRKQFKIRNMEVWAVGDLPVKEEDEEGDGHKRSVLDGNLEDR 426
            .||.|.|  ..:||||.. .|||.::.|:...|||||||| |.:|:..:|:   :|:||.:.|.:
Human   375 DFGKGHSRAKPTCTTYNS-PQLSAQENFQFDKMEVWAVGD-PSEEQLAKGN---KSILDADPEAQ 434

  Fly   427 AMLEIAGKKMHSDGLREPNMDD 448
            |:|||:|...||:||||...|:
Human   435 ALLEISGHSRHSEGLREVPDDE 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5149	NP_609110.1	DMP12	11..>67	CDD:293384	7/56 (13%)
CG5149	NP_609110.1	TLDc	232..400	CDD:214733	85/169 (50%)
MEAK7	NP_065998.3	TLDc	244..412	CDD:214733	85/168 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146836
Domainoid	1	1.000	160	1.000	Domainoid score	I4067
eggNOG	1	0.900	-	-		E1_KOG2557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375016at33208
OrthoFinder	1	1.000	-	-		FOG0003986
OrthoInspector	1	1.000	-	-		oto88296
orthoMCL	1	0.900	-	-		OOG6_105332
Panther	1	1.100	-	-	LDO	PTHR23354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3857
SonicParanoid	1	1.000	-	-		X4376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740