DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5149 and meak7

DIOPT Version :9

Sequence 1:	NP_609110.1	Gene:	CG5149 / 34013	FlyBaseID:	FBgn0031904	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001038430.2	Gene:	meak7 / 561678	ZFINID:	ZDB-GENE-050419-140	Length:	450	Species:	Danio rerio

Alignment Length:	431	Identity:	150/431 - (34%)
Similarity:	224/431 - (51%)	Gaps:	24/431 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LESAYKNASGGALEK-LTQDRLVETWSQTIERSLAESTAQYLFT-----PTKPGQQCVNLQLKKF 80
            |..|..:||.|...| |:.|.|..|..:....|:.:...|.|.:     |..||......||..|
Zfish    31 LHGARSSASAGKTSKGLSLDMLQLTMGKMASESMIKRVFQGLHSIDPGVPLHPGDGVSREQLLIF 95

  Fly    81 GEPYYIMERGTIDQKMQMLLGSMERSGNDTFNSKQLEQYIYSVIKSYVHLESTAKNSGIKEWHDL 145
               ...:.|||.:::..::|...|.:......::|:..::..::  |..:::.|....::.|...
Zfish    96 ---LADVLRGTAEERAPLVLAMAEGAKATVTTTEQIRGFMEDLV--YAAVQTLAHKGHLRAWQPE 155

  Fly   146 GFNTTERSAATFAKGLMRNLGKELEHTMPNDALERWLHVTPQFLQIWREVFSQLYCRHGGSKRNI 210
            ......:.....|:.|...|....::|.....||.||...|..     .:|.:|....|...  :
Zfish   156 RMGDGAQGVKLLAEQLTSELKPSDQNTCDIACLEDWLFRIPMM-----AMFLELLIGEGLGV--V 213

  Fly   211 IKEMEIPILPALCDAPQNSHYRPIIELPHVLYINAQLPREHRHKWRFLFSSKINGESFSTMLGKV 275
            :.....|.|...|.....:..|.::.||.:::::..||..|...||.|||:|::||||:.:||..
Zfish   214 LPSRPPPTLLPPCQFAPWTDLRCVLSLPLLMFLSPLLPEGHSAPWRMLFSTKMHGESFTRLLGSC 278

  Fly   276 LDKGPTLFFIEDEDQYIFGGYASETWSVKPQFGGDDSSLLYTLSPAMRCFSATTYNNHYQYLNLN 340
            ..:|||:..::|...:||||:||::|.|||||.||....|:::.|.||.|:.|.||:||.|||..
Zfish   279 KSRGPTVLLVKDTKGHIFGGFASQSWEVKPQFQGDSRCFLFSVFPYMRVFTCTGYNDHYMYLNQG 343

  Fly   341 QQTMPNGLGMGGQFDFWGLWIDCSFGDGQS--VESCTTYRDYVQLSKRKQFKIRNMEVWAVGDLP 403
            |||||||||||||..::|||:|..||.|.|  ...||||.. .|||..:.||:..:|||.||.||
Zfish   344 QQTMPNGLGMGGQHGYFGLWLDYDFGHGHSRARPRCTTYGS-PQLSADEDFKLDTLEVWGVGKLP 407

  Fly   404 VKEEDEEGDGHKRSVLDGNLEDRAMLEIAGKKMHSDGLREP 444
               |::|.|..|:|:||.:||.:||:|:.||.:||.|||||
Zfish   408 ---EEQEEDEKKKSILDADLEVQAMMEMTGKTLHSQGLREP 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5149	NP_609110.1	DMP12	11..>67	CDD:293384	14/50 (28%)
CG5149	NP_609110.1	TLDc	232..400	CDD:214733	82/169 (49%)
meak7	NP_001038430.2	TLDc	237..404	CDD:214733	81/167 (49%)
meak7	NP_001038430.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..450		10/16 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580284
Domainoid	1	1.000	161	1.000	Domainoid score	I3992
eggNOG	1	0.900	-	-		E1_KOG2557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3251
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375016at33208
OrthoFinder	1	1.000	-	-		FOG0003986
OrthoInspector	1	1.000	-	-		oto41490
orthoMCL	1	0.900	-	-		OOG6_105332
Panther	1	1.100	-	-	LDO	PTHR23354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3857
SonicParanoid	1	1.000	-	-		X4376
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790