Protein Alignment ninaC and MYO1

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1317
• Identity: 290/1317 - (22%)
• Similarity: 523/1317 - (39%)
• Gaps: 342/1317 - (25%)

  Fly   277 VEHPFLTELIENEDEMR-SDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAAL 340
            :.||..:..:.|..::| ||:..:            .|..|          :|.|.|  .:|..|
Yeast    46 IVHPLDSTEVSNLVQVRISDVFPV------------NPSTF----------DKVENM--SELTHL 86

  Fly   341 ENPVDENIIESLRHRILMGESYSFIGDILLSLNS----NEIKQEFPQEFHAKYRFKSRS---ENQ 398
            ..|   :::.:|..|......|::.|..|:::|.    |...::....:|.|:...|:|   ||.
Yeast    87 NEP---SVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLDENS 148

  Fly   399 -----PHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVES 458
                 ||||::|:.||:::|...:.|.|:::|||.:||:.|.:.::::|..:..|:......|..
Yeast   149 HEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNIAPVSG 213

  Fly   459 S--IKAILMLV-----------NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVA 510
            |  :::..|.:           ||.|..||:|:|......:.|.:.|.::||....|:|||.|:.
Yeast   214 SSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSRIV 278

  Fly   511 TTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDD--PEGN-VE 572
            ..:..:.|:||||.....:: .::||...||: ||.:..::        |.....|  |..| ||
Yeast   279 HQNSKERNYHIFYQLLSGLD-DSELKNLRLKS-RNVKDYKI--------LSNSNQDIIPGINDVE 333

  Fly   573 RYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRF-RQNGKYAEVENTDIVSRIAELLRVDEK 636
            .::|..:.|..|.|:..|:..:.:|:|.||.||||.| ....:.|..:|.  ||.|...|.||||
Yeast   334 NFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDRAEQASFKND--VSAICSNLGVDEK 396

  Fly   637 KFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTN 701
            .|..::.......|.....:...:::|:...:|::..||.||..:|::.||.|:....|..   |
Yeast   397 DFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATL---N 458

  Fly   702 AIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNF-YDNKTA 765
            .|.:.|:.|||.|..|..|||.||..||::|..:|..:|:.|..|...|:|....::: .|.:..
Yeast   459 YIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLT 523

  Fly   766 LDNLLTK--PDGLFYIIDDAS--RSCQDQDLIMDRVS---EKHSQFVKKHTATEISVAHYTGRII 823
            :|.:.:|  |.|:..::|:.:  ....|:......:|   :..|:|.:........:.||.|.:.
Yeast   524 IDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKFKRSRLKNGFILKHYAGDVE 588

  Fly   824 YDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALN 888
            |....:...|:|.:...::....||.::.|..:|                   :.|.|:.|
Yeast   589 YTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLF-------------------QPEGEKSS---- 630

  Fly   889 TLSAGCISQVNN-----------LRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPR 942
              |||..:.::|           .:|.::..|...:|||..|   |:...||||||..:...|.:
Yeast   631 --SAGVEANISNQEVKKSARTSTFKTTSSRHREQQITLLNQL---ASTHPHFVRCIIPNNVKKVK 690

  Fly   943 SFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL------AFDFDEPVE-MTKDNC 1000
            :|:..::..|::..|||:.:...::|:.:|:.|.||.:||:.|      ...|...:: .||.||
Yeast   691 TFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNC 755

  Fly  1001 RLLF--LRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMM-------RALLARKRV 1056
            ..|.  |:|..:.:.:|.||:|.:      ...|.:|:.:|.:|:.::|       |....||.:
Yeast   756 EFLLTSLQLDTKVYKIGNTKLFFK------AGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEI 814

  Fly  1057 KG-----------GKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLV------------NE 1098
            ..           |..|:|           .:::.|....|...:|:.||:            ||
Yeast   815 TYHLQKLKKTRVIGNTFRL-----------YNRLVKEDPWFNLFIRIKPLLTSSNDMTRTKKFNE 868

  Fly  1099 KSGQLN------------------------ENTADFIRPFAKKWRE--------KSIFQVLLHYR 1131
            :..:|.                        |||.|.:....:..|:        |:..:.|
Yeast   869 QINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKENLRKNESLLNRVKTSSETL---- 929

  Fly  1132 AARFQDFVN-----------LSQQVHIYNQRMVAGLNKC--TRAVPFERIN-------------- 1169
            ..:|.|.|:           ::|.:...:|: :.||.:.  .|....|:::
Yeast   930 QKQFDDLVSEKDEISREKLEVAQNLEEAHQK-IQGLQETIREREATLEKLHSKNNELIKQISDLN 993

  Fly  1170 ---MREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQ--AFPNQLLTQHMEDDEP 1229
               .:|.:|..|      ||:...:|:.    :.:.:.|..||...:  :| |..|:...||.:.
Yeast   994 CDISKEQSSQSL------IKESKLKLEN----EIKRLKDVINSKEEEIKSF-NDKLSSSEEDLDI 1047

  Fly  1230 WDSPLQRNPSMTSCAL----TYNA--------YKKEQACQTNWDRMGES---------------- 1266
            ....|::|.::....|    |.|:        :|||:|...|..:..||
Yeast  1048 KLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLKNKESELLKMKEKIDNHKKEL 1112

  Fly  1267 --------DNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKG 1323
                    |.:...|  :...:|:..::|  :..|.:.|......|
Yeast  1113 ATFSKQRDDAVSEHG--KITAELKETRIQ--LTEYKSNYQKIKEEY------------------- 1154

  Fly  1324 YAAPPPPPPPMPSSNYYRNNPNQQQRNYQQRSSYPPS---DPVRELQ---------NMARNEGDN 1376
                         ||:.|....|:|:   :|:|...|   ..::||:         |...|:..:
Yeast  1155 -------------SNFQRETKEQEQK---KRNSLVESLNDSKIKELEARLSQEISLNQYLNKRIS 1203

  Fly  1377 SEDPPFNFKAMLRKTNY 1393
            ......|..:..|.|:|
Yeast  1204 GNSVETNISSTRRSTSY 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	2/4 (50%)
		MYSc_Myo21	346..1022	CDD:276848	192/732 (26%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	290/1317 (22%)
		Smc	1607..>1901	CDD:440809