Protein Alignment ninaC and MYO5

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_013827.1
• Gene: MYO5 / 855136
• SGDID: S000004715
• Length: 1219
• Species: Saccharomyces cerevisiae
• Alignment Length: 1178
• Identity: 282/1178 - (23%)
• Similarity: 491/1178 - (41%)
• Gaps: 216/1178 - (18%)

  Fly   307 KTLYKEPELFVDRGYVKR--------FD-EKPEKMYPEDLAALENPVDENIIESLRHRILMGESY 362
            |.:::||        .||        || .|.:::...||..|....||.|.|:|:.|.|....|
Yeast    10 KKVHQEP--------AKRSANIKKATFDSSKKKEVGVSDLTLLSKISDEAINENLKKRFLNATIY 66

  Fly   363 SFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGES 427
            ::||.:|:|:|.......:......:|:.|:|.|..||:|::|:..|.:|..:.|.|.:::||||
Yeast    67 TYIGHVLISVNPFRDLGIYTDAVMNEYKGKNRLEVPPHVFAIAESMYYNMKSYNENQCVIISGES 131

  Fly   428 YSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLVN----AGTPVNNDSTRCVLQYCLTF 488
            .:||:..|:.:::::......:..:.|:::..:.|...|:.    |.|..||:|:|......:.|
Yeast   132 GAGKTEAAKRIMQYIAAASSTHTESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKF 196

  Fly   489 GKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPP 553
            ....:........|:|||.||.:....:.||||||.|....:...: :.:.::....|.|.....
Yeast   197 NNQFEPCAGNITNYLLEKQRVVSQIKNERNFHIFYQFTKGASDAYR-QTFGVQKPEQYVYTAAAG 260

  Fly   554 EVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGK-YAE 617
            .:....:    ||    ::.|:|....:|.|....::.:.:.::|||||.|||:.|.:|.: .|:
Yeast   261 CISAETI----DD----LQDYQETLKAMRVIGLGQEEQDQIFRMLAAILWIGNVSFIENEEGNAQ 317

  Fly   618 VENTDIVSRIAELLRVDEKKFMWSLTNFIM-----VKGGIAERRQYTTEEARDARDAVASTLYSR 677
            |.:|.:...:|.||::|.:..:.||...||     :|.|..........:|...|||:|..:|:.
Yeast   318 VRDTSVTDFVAYLLQIDSQLLIKSLVERIMETNHGMKRGSVYHVPLNIVQADAVRDALAKAIYNN 382

  Fly   678 LVDFIINRINMNM-SFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFI 741
            |.|:|::|:|.:: :||    |...:|.|.|::|||.|..|..||:.||.:||::|..:.|....
Yeast   383 LFDWIVSRVNKSLQAFP----GAEKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLK 443

  Fly   742 SEMLEMEAEDIDTINLNFYDNKTALDNL-LTKPDGLFYIIDDASRSCQ-DQDLIMDRVSEKHSQF 804
            ||....|.|.|....:.::|||...|.: ..:|.|:|..::|:..:.. |.:......:::.:.|
Yeast   444 SEQETYEREKIQWTPIKYFDNKVVCDLIEARRPPGIFAAMNDSVATAHADSNAADQAFAQRLNLF 508

  Fly   805 -VKKH---TATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAG 865
             ...|   .:.:..:.||.|.:.||....||.|:|.:..:::|...::.:..:..:|.:.:.:
Yeast   509 TTNPHFDLRSNKFVIKHYAGDVTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPDTVDR-- 571

  Fly   866 NLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFV 930
                         ||:|:.   .|.....|...|:              |::.||:   ....::
Yeast   572 -------------ESKRRP---PTAGDKIIKSAND--------------LVETLSK---AQPSYI 603

  Fly   931 RCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEM 995
            |.|:.:....|..:....|..|:|.||:.:.|..|:.||:.|..|::|:.|:..|:.......:.
Yeast   604 RTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRRAGFAYRQVFEKFVERFYLLSPHCSYAGDY 668

  Fly   996 TKDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKV-IKVQSMMRALLARKRVKGG 1059
            |            .:|..|...|..|:  :.....:.|:|.|..| ||....:.||
Yeast   669 T------------WQGDTLDAVKYILQ--DSSIPQQEYQLGVTSVFIKTPETLFAL--------- 710

  Fly  1060 KVFKLGKKGPEH------HDVAASKIQKAFRGFRDR-----VRLPPLVNE-KSGQLNENTADF-- 1110
                      ||      |::|| :||:|:|.|..|     .::...:.| |.|...|...|:
Yeast   711 ----------EHMRDRYWHNMAA-RIQRAWRRFLQRRIDAATKIQRTIRERKEGNKYEKLRDYGT 764

  Fly  1111 -IRPFAKKWREKSIFQVLLHYRAARFQDFV--NLSQQVHIYNQRMVAGLNKCTRAVPFERINMRE 1172
             :....|:.|..|    ||.|||. ..|::  |.|:....|.:|.|:...|...::..|.::.:.
Yeast   765 KVLGGRKERRSMS----LLGYRAF-MGDYLSCNESKSKGAYIKRQVSIKEKVIFSIHGEALHTKF 824

  Fly  1173 VNSSQ-------LGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDDEPW 1230
            ..|:|       |.|..:.|..... :.....|...|.:|..| |...:..|      ::||  |
Yeast   825 GRSAQRLKKTFLLTPTTLYIVGQTL-VQNAMTYTQDYKIDVRN-IQAVSLTN------LQDD--W 879

  Fly  1231 -----DSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQG---YFRDPQQLRRNQMQ 1287
                 .|..|.:|.:       |.|.|.:.. |:..|:.:...|....   |.:.|.:|...:.|
Yeast   880 VAIKLASSGQPDPLI-------NTYFKTELI-THLKRLNDKIQIKIGSAIEYQKKPGKLHSVKCQ 936

  Fly  1288 MNMNA--YNNAYNSYNSNY---NNQNWGVHRSGSRRNSL-KGYAA-------------------- 1326
            :|.:|  |.:.|.|...:.   |..|..||:...:::|: .||.|
Yeast   937 INESAPKYGDIYKSSTISVRRGNPPNSQVHKKPRKKSSISSGYHASSSQATRRPVSIAAAQHVPT 1001

  Fly  1327 ---------PPPPPPPMPSSNYYRNN-PNQQQRNYQQRSSYPPSDPVRELQ--------NMARNE 1373
                     |.||||.|.:....|.: ||........:|:..||.|....:        ..|...
Yeast  1002 APASRHSKKPAPPPPGMQNKAATRRSVPNPASTLTASQSNARPSPPTAATRATPAATPAAAAMGS 1066

  Fly  1374 GDNSEDPP 1381
            |..:..||
Yeast  1067 GRQANIPP 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	172/692 (25%)
MYO5	NP_013827.1	COG5022	1..1186	CDD:227355	282/1178 (24%)