Protein Alignment ninaC and MYO2

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_014971.1
• Gene: MYO2 / 854504
• SGDID: S000005853
• Length: 1574
• Species: Saccharomyces cerevisiae
• Alignment Length: 1214
• Identity: 281/1214 - (23%)
• Similarity: 520/1214 - (42%)
• Gaps: 202/1214 - (16%)

  Fly   284 ELIENE-DEMRSDIAEMLE----LSRDVKTLY--KEPELFVDRGYVKRFDEKPEKMYPEDLAALE 341
            |:|:|| ::.:..:...||    :|.|.|.|.  |:..|.:.|       ..|.....|||.:|.
Yeast    22 EVIKNEFNDGKYHLELQLEDDEIVSVDTKDLNNDKDQSLPLLR-------NPPILEATEDLTSLS 79

  Fly   342 NPVDENIIESLRHRILMGESYSFIGDILLSLNS-NEIKQEFPQEFHAKYRFKSRSENQPHIFSVA 405
            ...:..::.:::.|......|::.|.:|::.|. :.:.|.:.|:....|..|.|.|.:||:|::|
Yeast    80 YLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRRGELEPHLFAIA 144

  Fly   406 DIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGAT------GRVESSIKAIL 464
            :.||:.|.:.|:.|.||:||||.:||:.:|:.::::...:.:.|....      ...|..|.|..
Yeast   145 EEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSATVQHQVEMSETEQKILATN 209

  Fly   465 MLV----NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYF 525
            .::    ||.|..|::|:|......:.|.|...:.||....|:||:.|:......:.|:||||..
Yeast   210 PIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIERNYHIFYQL 274

  Fly   526 YDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQ 590
            ...:..|.: :|.:|....:|.|:....:...:.:    ||    .:.|:...:.|..:....:.
Yeast   275 MAGLPAQTK-EELHLTDASDYFYMNQGGDTKINGI----DD----AKEYKITVDALTLVGITKET 330

  Fly   591 LETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIA-ELLRVDEKKF-MWSLTNFIMVKG-GI 652
            ...:.|:|||:|:||||..::....|.:...:...::| |||.:|...| .|.....|:.:. .|
Yeast   331 QHQIFKILAALLHIGNIEIKKTRNDASLSADEPNLKLACELLGIDAYNFAKWVTKKQIITRSEKI 395

  Fly   653 AERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAII-IHDMFGFECFNR 716
            .....|:  :|..|:|:||..:||.|.|:::..||..:..| ||....::.| :.|::|||.|.:
Yeast   396 VSNLNYS--QALVAKDSVAKFIYSALFDWLVENINTVLCNP-AVNDQISSFIGVLDIYGFEHFEK 457

  Fly   717 NGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIID 781
            |..||..||..||::|..:||.:|..|..|...|:|:...:.|.||:..:| |:....|:..::|
Yeast   458 NSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFNDNQPCID-LIENKLGILSLLD 521

  Fly   782 DASRSCQDQD--------LIMDRVSEKHSQFVK-KHTATEISVAHYTGRIIYDTRAFTDINRDFV 837
            :.||.....|        ..:|: |..:..|.| :...|:..|:||...:.||...|.:.|||.|
Yeast   522 EESRLPAGSDESWTQKLYQTLDK-SPTNKVFSKPRFGQTKFIVSHYALDVAYDVEGFIEKNRDTV 585

  Fly   838 PPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSA---GCISQVN 899
            ....:|..::|.:|:::           |:....|....|.| |.|...|....:   |.|..||
Yeast   586 SDGHLEVLKASTNETLI-----------NILEGLEKAAKKLE-EAKKLELEQAGSKKPGPIRTVN 638

  Fly   900 NLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIA 964
            ...||.:.|:.:.:.|:..::   :..||::|||:.:.:.:...|.:.:|..|::|.|||:|:..
Yeast   639 RKPTLGSMFKQSLIELMNTIN---STNVHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETIRI 700

  Fly   965 RQKGFSSRLPFDEFLRRYQFL----AFDFDEPVEMTKDNCRLLFLRLKMEG-------WALGKTK 1018
            ...||.||..|:||:.||..|    .:|.....:.|.:...:..:::.::.       :.:|.||
Yeast   701 SCAGFPSRWTFEEFVLRYYILIPHEQWDLIFKKKETTEEDIISVVKMILDATVKDKSKYQIGNTK 765

  Fly  1019 VFLRYYNDEFLARLYELQVKK----VIKVQSMMRALLARKR--------------VKGGKVFKLG 1065
            :|   :....||.|.:|:..|    ::.:|..:||...||:              :||   |.:.
Yeast   766 IF---FKAGMLAYLEKLRSNKMHNSIVMIQKKIRAKYYRKQYLQISQAIKYLQNNIKG---FIIR 824

  Fly  1066 KKGPEHHDV-AASKIQKAFRGFRDRVRLPPLVNE------------KSGQLNE----NTADFIRP 1113
            ::..:...| .|:.:|.|:||...|..:..::..            |..||.:    |.|..|:.
Yeast   825 QRVNDEMKVNCATLLQAAYRGHSIRANVFSVLRTITNLQKKIRKELKQRQLKQEHEYNAAVTIQS 889

  Fly  1114 FAKKWREKSIF----------QVLLHYRAARFQ--------DFVNLSQQVHIYNQRMVAGLNKCT 1160
            ..:.:..:|.|          |.|:..|||:.:        ..||..::|....:..|..|.:..
Yeast   890 KVRTFEPRSRFLRTKKDTVVVQSLIRRRAAQRKLKQLKADAKSVNHLKEVSYKLENKVIELTQNL 954

  Fly  1161 RAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHME 1225
            .:...|...|.|    ::..|.|.:::.....:.:.....::::|..|..|:.....:.:..:::
Yeast   955 ASKVKENKEMTE----RIKELQVQVEESAKLQETLENMKKEHLIDIDNQKSKDMELQKTIENNLQ 1015

  Fly  1226 DDEPW--DSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQM 1288
            ..|..  |:.|:    :......::..|:|...|                 ..:.:|.::..::
Yeast  1016 STEQTLKDAQLE----LEDMVKQHDELKEESKKQ-----------------LEELEQTKKTLVE- 1058

  Fly  1289 NMNAYNNAYNSYNSNYNNQNWGVHRSGSRRN---SLKGYAAPPPPPPPMP------SSNYYRNN- 1343
                    |.:.|.:..|:...:....:|..   ||........|..|:.      :||:  ||
Yeast  1059 --------YQTLNGDLQNEVKSLKEEIARLQTAMSLGTVTTSVLPQTPLKDVMGGGASNF--NNM 1113

  Fly  1344 --------PNQQQRNYQQRSSYPPSDPVRELQNMA--RNEGDNS 1377
                    ||  ..|.:.||:  ||.....:.:::  |..|.|:
Yeast  1114 MLENSDLSPN--DLNLKSRST--PSSGNNHIDSLSVDRENGVNA 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	188/713 (26%)
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	281/1214 (23%)