Protein Alignment ninaC and MYH14

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001139281.1
• Gene: MYH14 / 79784
• HGNCID: 23212
• Length: 2036
• Species: Homo sapiens
• Alignment Length: 1402
• Identity: 304/1402 - (21%)
• Similarity: 565/1402 - (40%)
• Gaps: 296/1402 - (21%)

  Fly   279 HPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAALENP 343
            |.|....:.:|.|..::: |:.|..|         .|.:.|..::|.: .|:....||:|.|...
Human    63 HGFEAAALRDEGEEEAEV-ELAESGR---------RLRLPRDQIQRMN-PPKFSKAEDMAELTCL 116

  Fly   344 VDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIA 408
            .:.:::.:||.|...|..|::.|...:.:|..:....:.:.....||.|.|.|..||:::|.:.|
Human   117 NEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGA 181

  Fly   409 YQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLV------ 467
            |:.||..:|.|.|:.:|||.:||:.|.:.:|::|.::....:   ||.|..:.|.:..|
Human   182 YRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPK---GRKEPGVPASVSTVSYGELE 243

  Fly   468 --------------NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHN 518
                          ||.|..|::|:|......:.|...|.:.||....|:|||.|.......:.:
Human   244 RQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIVGANIETYLLEKSRAIRQAKDECS 308

  Fly   519 FHIFYYFYDFINQQNQLKEYNLKAD------RNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREF 577
            |||||.......:|       ||||      .:||:|...|...|.:.:          |.::|.
Human   309 FHIFYQLLGGAGEQ-------LKADLLLEPCSHYRFLTNGPSSSPGQER----------ELFQET 356

  Fly   578 ENILRDIDFNHKQLETVRKVLAAILNIGNIRFR--QNGKYAEVENTDIVSRIAELLRVDEKKFMW 640
            ...||.:.|:|:::.::.::::|:|..|||..:  :|...|.:.:.....::..||.:....|..
Human   357 LESLRVLGFSHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKLCRLLGLGVTDFSR 421

  Fly   641 S-LTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAII 704
            : ||..|.|.....::.| |.|:|..|.:|:|...|.||..:::  :.:|.:..|:.....:.:.
Human   422 ALLTPRIKVGRDYVQKAQ-TKEQADFALEALAKATYERLFRWLV--LRLNRALDRSPRQGASFLG 483

  Fly   705 IHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNF-YDNKTALDN 768
            |.|:.|||.|..|..|||.||..||::|..:|..:|:.|..|.:.|.|....|:| .|.:..:|
Human   484 ILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCID- 547

  Fly   769 LLTK---PDGLFYIIDDASRSC-----QDQDLIMDRVSEK---HSQFVK-KH--TATEISVAHYT 819
            |:.:   |.||..::|:   .|     .|:..: ::|:::   |.:|.: :|  ...:.||.||.
Human   548 LIERPANPPGLLALLDE---ECWFPKATDKSFV-EKVAQEQGGHPKFQRPRHLRDQADFSVLHYA 608

  Fly   820 GRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMF---TNQLTKAGNLTMPFEAVQHKDE-- 879
            |::.|....:...|.|            .|::::..:.   |::||          |...|||
Human   609 GKVDYKANEWLMKNMD------------PLNDNVAALLHQSTDRLT----------AEIWKDEHG 651

  Fly   880 ------------------SERKSYALNTLSAGCI---SQVNNL--------------RTLAANFR 909
                              :||.|.|::......|   .||::|              ||:...::
Human   652 GFQQFSFLGSFPPSPPGSAERCSSAISPPGVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYK 716

  Fly   910 FTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLP 974
            .:...|:..||   |....|||||..:.|.:.......:|..|::..|||:.:...::||.:|:.
Human   717 ESLSRLMATLS---NTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRIL 778

  Fly   975 FDEFLRRYQFLAFDFDEPVEMT------KDNCRLLFLRLKMEG--WALGKTKVFLRYYNDEFLAR 1031
            |.||.:||:.|.     |..:.      |..|..:...|:::.  :.:|::|:|.|   ...||:
Human   779 FQEFRQRYEILT-----PNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFR---AGVLAQ 835

  Fly  1032 LYELQVKKV----IKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRL 1092
            |.|.:..||    :..|:..|..|||:..:..:..:...:..:.:..|..|: :.::.:|...::
Human   836 LEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKL-RHWQWWRLFTKV 899

  Fly  1093 PPL------------------------------VNEKSG---QLNE---NTADFIRPFAKKWREK 1121
            .||                              |.|..|   ||.|   ..|:.:|..|:...|.
Human   900 KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 964

  Fly  1122 SIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMRE--------VNSSQL 1178
            ...:..|   |||.|:...:..::    :..|....:|:|.:..|:..:::        :.:.:.
Human   965 EETRGRL---AARKQELELVVSEL----EARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022

  Fly  1179 GPLPVPIKKMPFRLDQIPFYDTQYMVDPANS-ISRQAFPNQLL--------TQHMEDDEPWDSPL 1234
            ....:.::|:........|.:...:::..|| :|::   .:||        :|..|::|
Human  1023 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE---RKLLEDRLAEFSSQAAEEEE------ 1078

  Fly  1235 QRNPSMTSCALTYNA--------YKKEQACQTNWDRM-----GESDNIYNQGYFRDPQQLRRNQM 1286
             :..|:....|.|.|        .:||:..:...:::     |||..:..|   ...||.|..::
Human  1079 -KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQ---MVEQQQRAEEL 1139

  Fly  1287 QMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLK----GYAAPPPPPPPMPSSNYYRNNPNQQ 1347
            :..:........:..:...::      .|:|...||    ..||.......:.|....|....:|
Human  1140 RAQLGRKEEELQAALARAEDE------GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQ 1198

  Fly  1348 QRNY---------QQRSSYPPSDPVRELQNMARNEGDNSEDPPFNFKAMLRKT--NYPRGSETNT 1401
            :|:.         :...:...::..:||:  ::.|.:.:|         |:||  ...|..|...
Human  1199 RRDLGEELEALRGELEDTLDSTNAQQELR--SKREQEVTE---------LKKTLEEETRIHEAAV 1252

  Fly  1402 YDFNNRRGSDSGDQHTFQPPKLRSTG-----RRYQDDE--GYNSSSGNYGVSRKFGQQQRAPTLR 1459
            .:...|.|...|:.........|..|     |...:.|  ...:...:...:|:.|:|:|.....
Human  1253 QELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLEL 1317

  Fly  1460 QSPASVGRSFEDSNARSFEEAGSYVEEEIAPGITLSG 1496
            |.....||:.:...||:  ||...::...|....:||
Human  1318 QLQEVQGRAGDGERARA--EAAEKLQRAQAELENVSG 1352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	1/2 (50%)
		MYSc_Myo21	346..1022	CDD:276848	190/767 (25%)
MYH14	NP_001139281.1	MYSc_Myh14_mammals	119..829	CDD:276893	190/767 (25%)
		Myosin_tail_1	906..1986	CDD:460256	82/486 (17%)