DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaC and myo15b

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_017214038.2	Gene:	myo15b / 795537	ZFINID:	ZDB-GENE-030131-4797	Length:	1899	Species:	Danio rerio

Alignment Length:	789	Identity:	151/789 - (19%)
Similarity:	268/789 - (33%)	Gaps:	250/789 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   822 IIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYA 886
            ::.....|.:.|.|...||::|.|..|..:.:..:|..         :....:|.|:....:.:.
Zfish     5 VVAKVHNFLNKNHDQFRPEVLELFARSRLQMVSGLFRK---------VQERYIQQKELGRARGHR 60

  Fly   887 LNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQ 951
                        |.:.|:||||:   .:|.::.::.......||||.:.:....|..|..|.:..
Zfish    61 ------------NQMSTVAANFQ---QSLTELTTRLERCKTTFVRCFKPNYVKLPGIFDVDYITT 110

  Fly   952 QMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMT-KDNCRLLFLRLKMEG--WA 1013
            |::..|:|:|:..|::||..|:||.:|:.||..|.  ...|:..: ::....|...:..|.  :.
Zfish   111 QLRHGGILETIHIRKEGFPIRIPFAQFMERYGVLL--SQRPINQSLEEQVVTLIETIGAEDGQYQ 173

  Fly  1014 LGKTKVFLRYYNDEFLARLYELQVKK---------VIKVQSMMRALLARKRVKGGKVFKLGKKGP 1069
            ||.|||||:       ..||: ||::         .:.:|..:|..:.|:.      |:..||
Zfish   174 LGLTKVFLK-------ETLYQ-QVEEKWSSTQTWAAVTIQRNIRGFICRRN------FQFFKK-- 222

  Fly  1070 EHHDVAASKIQKAFRGFRDRVRLPPLVN-----EKSGQLNENTADFIRPFAKKWREKSIFQVLLH 1129
                 .|..||...||.:.|.....|..     ..:..:..||..     .:.|:|        |
Zfish   223 -----KAIVIQSHIRGHQARKYFKQLKQCFTQFWATMMITRNTIK-----RRHWKE--------H 269

  Fly  1130 YRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFE---RINMREVNS-----SQLGPLPVPIK 1186
            ...:|.::....:..    :..|..|:.:    :|.|   |:......|     |::.|..|...
Zfish   270 TDRSRVKEVAKPTSS----SSEMDVGILE----IPAELSARLRSSSGRSQGSGVSEVAPPQVKAD 326

  Fly  1187 ---KMPFRLDQIPFYDTQYMVDPANSISR------QAFPNQLLTQHMEDDEPWDSPLQRNPSMTS 1242
               .:|..:|:.||  :||    ||::.:      |.:|.|         .|..| |....:.|:
Zfish   327 HKLSLPLDIDRHPF--SQY----ANTVLKDGWCQAQGYPLQ---------RPLTS-LDHEDARTA 375

  Fly  1243 CALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQLR---RNQMQMNMNAYNNAYNSYNSNY 1304
            ..:    ||.......:.|..|..:.:.. .|..:..|:|   |:::...:     .|.:::.:.
Zfish   376 LEI----YKLILRFTGDSDLNGWQEQMLG-NYIVEKSQIRPGIRDEILAQL-----VYLTWDGDR 430

  Fly  1305 NNQNWGVHRSGSRRNSLKGY--------AAPPPPPPPMPSSNYYRNNPNQQQRNYQQR---SSYP 1358
            ...|            |:|:        |..|.|....|...|..:....:.|:..|.   :|.|
Zfish   431 QETN------------LRGWLLLACCLSAFTPSPDLEKPLLKYVSDRGPGEYRSLCQHKLLTSLP 483

  Fly  1359 -PSDPVRELQNMARNEGDNSEDPPFNFKAMLRKTNYPRGSETNTYDFNNRRGSDSGDQHTFQPPK 1422
             ||...|             ..||...:                :..|.|:|....:.:||...|
Zfish   484 LPSPACR-------------RHPPTQLE----------------WTANQRKGKMVLEVNTFNEEK 519

  Fly  1423 LR------STGRRYQD---------------------DEGYNSSSG------------------- 1441
            |.      :||.....                     |||:...:|
Zfish   520 LAVEVESWTTGEELASWILSYRGLTNATQGWSVSLLADEGWTDLTGCDFVMDLLAGVESDVPMGH 584

  Fly  1442 -----NYGVSRKFGQQQR---------APTLRQSPASVGRSFEDSNARSFEEAGSYVEEEIAPGI 1492
                 :|..|....:.:.         ||:: |:|..  .|||.|:..::|...:|   :.:.|.
Zfish   585 PPTENDYLFSDTSDRMETTDIDAFIPPAPSM-QAPGL--PSFEASHWNTYEPLSTY---QGSQGR 643

  Fly  1493 TLSGYAVDI 1501
            .:..|..||
Zfish   644 QMDSYVDDI 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		S_TKc	16..282	CDD:214567
		MYSc	327..1034	CDD:214580	50/214 (23%)
		MYSc_Myo21	346..1022	CDD:276848	48/202 (24%)
myo15b	XP_017214038.2	Motor_domain	<5..182	CDD:328930	48/202 (24%)
		IQ	221..241	CDD:279006	8/26 (31%)
		MyTH4	359..503	CDD:321946	32/204 (16%)
		GGN	<812..>962	CDD:330621
		SH3	1262..1316	CDD:327375
		MyTH4	1476..1581	CDD:307090
		FERM_B-lobe	1590..1791	CDD:324381
		FERM_C_MyoXV	1787..1887	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900