Protein Alignment ninaC and Myo1e

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_011241116.1
• Gene: Myo1e / 71602
• MGIID: 106621
• Length: 1119
• Species: Mus musculus
• Alignment Length: 1151
• Identity: 276/1151 - (23%)
• Similarity: 492/1151 - (42%)
• Gaps: 240/1151 - (20%)

  Fly   335 EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQP 399
            :|:..|....:.:|:|:|:.|.:....:::||.:|:|:|..:....|.::....|:..::.||.|
Mouse    34 DDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEVEMYQGAAQYENPP 98

  Fly   400 HIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAIL 464
            ||:::||..|::|:..:|.|.:::||||.:||:..|:.::.::..:..|     |.....:|.|:
Mouse    99 HIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGG-----GPKVQHVKDII 158

  Fly   465 M--------LVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHI 521
            :        ..||.|..||:|:|....:.:.|...|:..|...:.::|||.||...:..:.:|||
Mouse   159 LQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHI 223

  Fly   522 FYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDID- 585
            ||...:..:.: |.:...:.:...|.||.:..       .|:.||    ::..|:|:..|..::
Mouse   224 FYQLIEGASPE-QKQSLGITSMDYYYYLSLSG-------SYKVDD----IDDKRDFQETLHAMNV 276

  Fly   586 ---FNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIM 647
               |:.:| ..|.:::|.||::|||.|::.|.||.||:.:.::..|.||.:::.:....||:..|
Mouse   277 IGIFSEEQ-TLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQM 340

  Fly   648 VK--GGIAERRQYT--TEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDM 708
            ..  ||.:|....|  .|:|...|||:|..|::|:.||:::.||..|......:.    |.:.|:
Mouse   341 DSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYN----IGVLDI 401

  Fly   709 FGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAED-----IDTINLNFYDNKTALDN 768
            :|||.|.:||.||..||.:||::     |:|||...|:.|.|:     |....:.:::||...|.
Mouse   402 YGFEIFQKNGFEQFCINFVNEKL-----QQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDL 461

  Fly   769 LLTK--PDGLFYIIDDASRSCQ------DQDLI----MDRVSEKH-----SQFVKKHTATEISVA 816
            :.:|  |.|:..|:||...:..      ||.|:    |...|.:|     ..|:         :.
Mouse   462 IESKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFI---------IH 517

  Fly   817 HYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESE 881
            ||.|::.||...|.:.|||.:..::||..:||....|..:|...|              ..|:..
Mouse   518 HYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENL--------------QADKKG 568

  Fly   882 RKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHS 946
            |.:.|.:.:.    .|.|:|.:          ||:|...       |::|||:.:...||:.:..
Mouse   569 RPTTAGSKIK----KQANDLVS----------TLMKCTP-------HYIRCIKPNETKKPKDWEE 612

  Fly   947 DVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFL----RL 1007
            ..|:.|::.||:.:.:..|:.|::.|..|.:||:||..|. ....||....:...:|.|    .:
Mouse   613 SRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILT-KATWPVWRGDEKQGVLHLLQSVNM 676

  Fly  1008 KMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHH 1072
            ..:.:.||::|||::.....||  |.|::.:|                                :
Mouse   677 DSDQFQLGRSKVFIKAPESLFL--LEEMRERK--------------------------------Y 707

  Fly  1073 DVAASKIQKAFRGFRDRVRLPP--------LVNEKSGQLNENTADFI--------RPFAKKW--- 1118
            |..|..|||.:|.|..|.:...        |:|:|..:.|....:||        ||..:::
Mouse   708 DGYARVIQKTWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEERPELQQFVGK 772

  Fly  1119 REKSIFQVLLHYRAARF----QDFVNLSQQVHIYNQRMV-AGLNK-CTRAVPFERINMREVNSSQ 1177
            |||..|...:.....||    :|.:...:.:::..:..| .|.:| ..:.|...||.:..:.|..
Mouse   773 REKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGVVKEVLKRRIEVERILSVS 837

  Fly  1178 LGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQ---LLTQHMEDDEPWDSPLQRNPS 1239
            |..:         :.|....::.:|     :|:....|..:   ||.:..|:......||:.:.:
Mouse   838 LSTM---------QDDIFILHEQEY-----DSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNT 888

  Fly  1240 MTSCALTYNAYKKEQACQTNWD--RMGESDNI-YNQGYFRDPQQLRRN----QMQMNMNAYNNAY 1297
            :..      ..|||     ||.  ..|.|..: ::|| |.|...|:.:    |:.:......|:.
Mouse   889 LEL------KLKKE-----NWGPWSAGGSRQVQFHQG-FGDLAILKPSNKVLQVSIGPGLPKNSR 941

  Fly  1298 NSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPP-------------PPPMPSSNYYRNN------ 1343
            .:..:...::.:    .|..:|:....|||.||             |||....|...|.
Mouse   942 PTRRNTVTSRGY----PGGTKNNYPMRAAPAPPGCHQNGVIRNQFVPPPHAFGNQRSNQKSLYTS 1002

  Fly  1344 ------PNQQQRNYQQRSSYPPSDPVREL--QNMARNEGDNSEDPP 1381
                  |.||.....:.|..|.|....::  |.:|......|..||
Mouse  1003 MARPPLPRQQSTGSDRLSQTPESLDFLKVPDQGVAGVRRQTSSRPP 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	192/717 (27%)
Myo1e	XP_011241116.1	MYSc_Myo1	45..691	CDD:276829	192/717 (27%)
		Myosin_TH1	731..932	CDD:461801	45/226 (20%)
		SH3_MyoIe_If_like	1067..1118	CDD:212761