DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and Myo3a

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_680779.3	Gene:	Myo3a / 667663	MGIID:	2183924	Length:	1621	Species:	Mus musculus

Alignment Length:	1482	Identity:	459/1482 - (30%)
Similarity:	705/1482 - (47%)	Gaps:	186/1482 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YAQLPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQV--SIEEEYRTLRDYC 68
            :...|||:|.:||.|.|.:|...|||:.....:.:..|:||  .|..|.:  .||.||..||...
Mouse    19 FDNFPDPSDTWEIIETIGKGTYGKVFKVLNKKSGQKAAVKI--LDPIHDIDEEIEAEYNILRTLS 81

  Fly    69 DHPNLPEFYGVY-KLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRA 132
            ||||:..|||:| |..|.|| |::|.|:|.|.||:..|:|...||...||.|..||||:.|....
Mouse    82 DHPNVVRFYGIYFKKDKING-DKLWLVLELCNGGSVTDLVKGFLKRGERMSEPVIAYILHEALMG 145

  Fly   133 AIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMES 197
            ...|:.|..:|||::|:|||||..|.|||.|||:|.|:.||..:..|.:|:|.||||||::..:.
Mouse   146 LQHLHSNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIACEQQ 210

  Fly   198 REPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISES 262
            .:.....|.|.|:||||.|||.||.||.|::||.||:|:|.|||||.|.:|..||.:.|||||:.
Mouse   211 LDTTYDARCDTWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKC 275

  Fly   263 LEKNAENRPMMVEMVEHPFLTELIENEDE-MRSDIAEMLELSRDVKTLYK--EPELFVDRGYVKR 324
            |.|:.|.||.:.::::|.|:|: ||.:|. ::..:.|.:::.:.:.:..|  ...:...:|.:.|
Mouse   276 LTKDYEKRPTVSDLLKHKFITQ-IEGKDVILQKQLMEFIDIHQCLGSTEKARHERIHTKKGNLNR 339

  Fly   325 FDEKPEKMYPEDLAALENPVDENII-ESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAK 388
            ......|.. :|||.|: .:|||.: |.|.......:.|.::||||::||..:....:..:....
Mouse   340 SLISSLKDV-DDLATLD-VLDENTVSEHLEKCYSRDQIYIYVGDILIALNPFQSLGIYSTKLSRL 402

  Fly   389 YRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGAT 453
            |....|:.|.||||::||:.||.|:.:...|.||:||||.:||:.:|.||::.|..||..|...
Mouse   403 YIGAKRTANPPHIFAMADLGYQSMVTYNADQCIVISGESGAGKTESAHLLVQQLTVLGKANNRT- 466

  Fly   454 GRVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDG 514
              ::..|..:..||    ||.|.:|::|:|......:.|..:|.:.||..:.|:|||.||.....
Mouse   467 --LQEKILQMNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAI 529

  Fly   515 TQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVE------- 572
            .:.|||||||.|..:.::.:|..|.|           |...||   :|.::|....|:
Mouse   530 GEKNFHIFYYIYAGLAEKKKLALYKL-----------PENKPP---RYLQNDNLRTVQDMMNNSF 580

  Fly   573 ---RYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVE-----NTDIVSRIAE 629
               :|...|...:.|.|..:||.:|..|||||||:|||.|.......:::     |...:...|.
Mouse   581 YKSQYELIEQCFKVIGFTMEQLGSVYSVLAAILNVGNIEFSSVATEYQMDKSYICNHTALENSAS 645

  Fly   630 LLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPR 694
            ||.:...:...:||:..:|..|....|..|.|:|.|.|||:|.|||.||..:|:|.||..:....
Mouse   646 LLCIQADELQEALTSHCVVTRGETIIRPNTVEKAADVRDAMAKTLYGRLFSWIVNCINSLLKHDT 710

  Fly   695 AVFGDTNAII-IHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLN 758
            :..||....| |.|:||||.|.||..|||.||..|||:||::||.:|..|..|...||:|...:.
Mouse   711 SPSGDEELNIGILDIFGFENFKRNSFEQLCINIANEQIQYYFNQHVFAWEQNEYLNEDVDARVIE 775

  Fly   759 FYDNKTALDNLLTKPDGLFYIIDDASR--SCQDQDLIMDRVSEKHSQFVKKHTATEIS--VAHYT 819
            :.||:..||..|.||.||..::|:.||  ...||.||........||:..:....|:|  :.||.
Mouse   776 YEDNRPLLDMFLQKPMGLLSLLDEESRFPKATDQTLIEKFEDNLKSQYFWRPKRMELSFGIHHYA 840

  Fly   820 GRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTM--PFEAVQHKDESER 882
            |:::|....|...|||..|.:::...|||.:..|..:..:.|||.|||.:  ....|.::..:..
Mouse   841 GKVLYSASGFLAKNRDTFPTDIVLLLRSSENSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMWNSE 905

  Fly   883 KSYAL---NTLSAGC-ISQVNNLR--TLAANFRFTCLTLL-KMLSQNANLGVHFVRCIRADLEYK 940
            ||..|   .|....| ..:..|::  |:::.||::.:.|| ||:....    ||||||:.:.|.:
Mouse   906 KSTNLTKGETRDVTCHACETTNVKTQTVSSYFRYSLMDLLSKMVVGQP----HFVRCIKPNNERQ 966

  Fly   941 PRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFL 1005
            .|.:..:.|..|::..|:|:|...|:.|:|.|:.|..|::||..|.:...|...::.|.|..:..
Mouse   967 ARKYDKEKVLLQLRCTGILETARIRRLGYSHRILFANFIKRYYILCYKSSEEPPVSPDTCAAILE 1031

  Fly  1006 RLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPE 1070
            :..::.||||||||||:||:.|.|..:.:....|::.:|:.:||.|..:|.:     :|.:|
Mouse  1032 KAGLDNWALGKTKVFLKYYHVEQLNLMRKEATNKLVLIQASVRAFLGARRYQ-----ELQQK--- 1088

  Fly  1071 HHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYRAARF 1135
             ...:|..||.|.|  |..:|       |.|:...|        .|....:||        .|:.
Mouse  1089 -RKSSAVIIQSAAR--RHLLR-------KHGKETSN--------VKSAAGRSI--------RAKD 1127

  Fly  1136 QDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPF--- 1197
            |:|   ..:.:...:|......:...|||....|....|:.:   .|...|..|||.:....
Mouse  1128 QEF---DYKKNFETKRESFVKKQTENAVPTNESNTSTPNNKE---SPSAGKTAPFRAESKATNVE 1186

  Fly  1198 -----YDTQ---------------YMVDPANSISRQAFPNQLLTQHMED------DEPWDSPLQR 1236
                 |.||               |:|:...:   :..|.|...|.:|:      :|..|:.:|
Mouse  1187 SNNRRYHTQKKMSNVYAEGQNQELYIVEDTWA---EVSPRQKYVQDLEESRKMRKEEKGDAVIQ- 1247

  Fly  1237 NPSMTSCALTY----NAYKKEQAC---QTNWDR-----MGESDNIYNQGYFRDPQQLRRNQMQMN 1289
                 |....|    |..:.:..|   :..|:|     :..::.||.:... || .|.:..:..|
Mouse  1248 -----SYCQWYTEGSNFEESKATCLEGRETWERTSCPGLWLTEEIYLRKTL-DP-TLSQKSVYQN 1305

  Fly  1290 MNAYNNAYN----SYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRN 1350
            .:.....:.    :.|:...|.....|..|.......|         |:|.:       .::.:.
Mouse  1306 ADGKEKEHKVSVVTQNAPLGNLERDYHLLGFLGEEDTG---------PVPQA-------QEEHKA 1354

  Fly  1351 YQQRSSYPPSDPVRELQNMARNEGDNSEDPPFNFKAMLRKTNYPRGSETNTY 1402
            ....|.|..|...::|       |.:...|||..:.:|..:.....:..|.|
Mouse  1355 VSIHSKYQSSKKKQQL-------GKDRLAPPFKNQKILSSSTEVAKTTHNVY 1399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	126/275 (46%)
		S_TKc	16..282	CDD:214567	122/268 (46%)
		MYSc	327..1034	CDD:214580	247/740 (33%)
		MYSc_Myo21	346..1022	CDD:276848	236/709 (33%)
Myo3a	NP_680779.3	PKc_like	10..295	CDD:304357	126/278 (45%)
		S_TKc	29..295	CDD:214567	122/268 (46%)
		MYSc	345..1060	CDD:214580	247/737 (34%)
		MYSc_Myo3	360..1048	CDD:276830	235/708 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49486
Inparanoid	1	1.050	611	1.000	Inparanoid score	I914
Isobase	1	0.950	-	0	Normalized mean entropy	S3935
OMA	1	1.010	-	-		QHG52654
OrthoDB	1	1.010	-	-		D25137at33208
OrthoFinder	1	1.000	-	-		FOG0003766
OrthoInspector	1	1.000	-	-		otm42503
orthoMCL	1	0.900	-	-		OOG6_104503
Panther	1	1.100	-	-	O	PTHR46256
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2623
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790