Protein Alignment ninaC and MYO1G

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_149043.2
• Gene: MYO1G / 64005
• HGNCID: 13880
• Length: 1018
• Species: Homo sapiens
• Alignment Length: 881
• Identity: 227/881 - (25%)
• Similarity: 389/881 - (44%)
• Gaps: 167/881 - (18%)

  Fly   326 DEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFP---QEFHA 387
            :|.||...| |...|:....|:.:.:|:.|...|..|::||::|:|:|.   .||.|   .|..|
Human     4 EEGPEYGKP-DFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNP---YQELPLYGPEAIA 64

  Fly   388 KYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGA 452
            :|:.:...|..||:::||:.||:.|.|......||:||||.:||:..::.:::::..:.:.::.|
Human    65 RYQGRELYERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRA 129

  Fly   453 TGRVESSIKAILM--------LVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRV 509
              .|| .:|.:|:        ..||.|..|::|:|......:.|...|...|...:.|:|||.||
Human   130 --EVE-RVKDVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRV 191

  Fly   510 ATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDP------- 567
            ......:.|||.||..... ::..||.|.:|  :||           |:...:.....
Human   192 LKQHVGERNFHAFYQLLRG-SEDKQLHELHL--ERN-----------PAVYNFTHQGAGLNMTVH 242

  Fly   568 ---EGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRF---RQNGKYAE---VENTDI 623
               :.:.:.::.....:|.|.|:.:::|:|.::|||||::|||.|   .:.|...|   |....:
Human   243 SALDSDEQSHQAVTEAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEAL 307

  Fly   624 VSRIAELLRVDEKKFMWSLTNFIMVKGG--IAERRQYTTEEARDARDAVASTLYSRLVDFIINRI 686
            |..:|||........:.||....:..||  :.| :.:|..||..||||.|..:|.||.::::|||
Human   308 VDHVAELTATPRDLVLRSLLARTVASGGRELIE-KGHTAAEASYARDACAKAVYQRLFEWVVNRI 371

  Fly   687 NMNMS----FPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEM 747
            |..|.    .||....|| .|.:.|::|||.|..|..||..||..||::|..:.|.|...|..|.
Human   372 NSVMEPRGRDPRRDGKDT-VIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEY 435

  Fly   748 EAEDIDTINLNFYDNKTALDNLLTKPD-GLFYIIDDASRSCQDQDLIMDRV----SEKHSQFVKK 807
            |.|.|...::.:::|.|.:| |:.:|. |:..::|:|   |.....|.||:    .:.|.:....
Human   436 EREGITWQSVEYFNNATIVD-LVERPHRGILAVLDEA---CSSAGTITDRIFLQTLDMHHRHHLH 496

  Fly   808 HTATEI-------------SVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTN 859
            :|:.::             .:.||.|.:.|....|.|.||||:..:......:|.|.::..|:.:
Human   497 YTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPD 561

  Fly   860 ------QLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKM 918
                  ::||                        ..|:||         ||..|      :::.:
Human   562 GQQDITEVTK------------------------RPLTAG---------TLFKN------SMVAL 587

  Fly   919 LSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQ 983
            :...|:....:||||:.:.:........:..:.|:..||:|:.|..|:.||:||.|:..||.||:
Human   588 VENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYK 652

  Fly   984 FLAFDFDEPVEMTKDNCRLLFLRLKMEGW----ALGKTKVFLRYYN-----DEFLARLYELQVKK 1039
             :..::..|..:...:...:...|:..|.    |.|.:|:|:|...     ::..|||..:   .
Human   653 -MTCEYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPI---I 713

  Fly  1040 VIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAA--SKIQKAFRGF-------RDRV-RLPP 1094
            |:.:|...|..|||.|.:..:......:....|.|.|  :::|:.|:..       ||.| .|||
Human   714 VLLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPP 778

  Fly  1095 LVNEKSGQLNENTADFIRPFAK-------KWREKSI 1123
            .|              ::||..       :||.:.:
Human   779 AV--------------LQPFQDTCHALFCRWRARQL 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	194/736 (26%)
MYO1G	NP_149043.2	MYSc_Myo1	23..694	CDD:276829	194/736 (26%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	584..606		5/21 (24%)
		Myosin_TH1	815..980	CDD:461801