Protein Alignment ninaC and myo5b

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_021324561.1
• Gene: myo5b / 567402
• ZFINID: ZDB-GENE-031219-7
• Length: 1840
• Species: Danio rerio
• Alignment Length: 1412
• Identity: 309/1412 - (21%)
• Similarity: 556/1412 - (39%)
• Gaps: 361/1412 - (25%)

  Fly   282 LTEL--------IENEDEM-RSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYP--- 334
            :|||        |.:.||: ||     .|:.:|    |||.:..:   ::|..||...: ||
Zfish     3 VTELYSKYTRVWIPDPDEVWRS-----AEIIKD----YKEGDTVL---HLKLEDESTLE-YPIGS 54

  Fly   335 --EDLAALENP---VDEN------------IIESLRHRILMGES---YSFIGDILLSLNSNEIKQ 379
              ..|..|.||   |.||            ::.:|:.|.|  ||   |::.|.:|:::|..|...
Zfish    55 KDNPLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFL--ESNHIYTYCGIVLVAINPYEQLH 117

  Fly   380 EFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCY 444
            .:.:|....|..::..:..||||:||:.|::.|...::.|.|::||||.:||:.:|:..::....
Zfish   118 IYGEEVINAYSGQNMGDMDPHIFAVAEEAFKQMARDEKNQSIIVSGESGAGKTVSAKYAMRFFAT 182

  Fly   445 LGDGNRGATGRVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLE 505
            :| |:...| .||..:.|...::    ||.|..|::|:|......:.|.:...:.||....|:||
Zfish   183 VG-GSANDT-NVEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDRRYHIIGANMRTYLLE 245

  Fly   506 KLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGN 570
            |.||......:.|:||||......:.. :.|:..|.:..::.|..:...:              .
Zfish   246 KSRVVFQAEEERNYHIFYQLCASCSLP-EFKDLTLTSAEDFTYTSLGENI--------------F 295

  Fly   571 VERYREFENILR--------DIDFNHKQLETVRKVLAAILNIGNIRFRQ--NGKYAEVENTDI-V 624
            :|...:.|::::        .:..||:.  ::.|::|:||::||:...|  :|:...:...|. :
Zfish   296 IEGVNDAEDLVKTREALTMLGVKENHQM--SIFKIIASILHLGNVEIVQERDGESCHINRNDTHL 358

  Fly   625 SRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEE----------ARDARDAVASTLYSRLV 679
            .....||.:::::          ::..:..|:..||.|          |.:||||:|..:|:.|.
Zfish   359 HHFCRLLGIEQEQ----------MENWLCRRKLVTTSETYVKNMPHSQAVNARDALAKHIYAHLF 413

  Fly   680 DFIINRINMNM-------SFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQ 737
            |:|:..||.::       ||          |.:.|::|||.|..|..||..||..||::|..:|.
Zfish   414 DWIVEHINKSLHTSTKQHSF----------IGVLDIYGFETFEINSFEQFCINYANEKLQQQFNS 468

  Fly   738 RIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQ-----DQDLIMDRV 797
            .:|..|..|...|.|....::||||:..:| |:....|:..::|:   .|:     ||:. ..::
Zfish   469 HVFKLEQEEYMKEQIPWTLIDFYDNQPCID-LIEAKLGILDLLDE---ECKVPKGTDQNW-AQKL 528

  Fly   798 SEKHS---QFVKKHTATE-ISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFT 858
            ..|||   .|.|...:.: ..|.|:..::.|....|.:.|||.|..|.|...::|..:.:..:|.
Zfish   529 YSKHSGSGHFEKPRMSNKSFIVVHFADKVEYQCDGFLEKNRDTVYEEQINILKASKFQLVADLFD 593

  Fly   859 NQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNN---LRTLAANFRFTCLTLLKMLS 920
            :..          :|..|...   |:..:|...|....:.:|   .:|:...||.:...|::.|:
Zfish   594 DAK----------DAAPHPGS---KTSRINVRPAKPAPKGHNREHRKTVGTQFRNSLHLLMETLN 645

  Fly   921 QNANLGVHFVRCIRADLEYKPR-SFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQF 984
            ...   .|:||||:.: :||.. .|.|....||::|.|||:|:.....|:.||..:.:|..||:.
Zfish   646 ATT---PHYVRCIKPN-DYKESFVFDSRRAVQQLRACGVLETIRISAAGYPSRWTYPDFFSRYRV 706

  Fly   985 LAFDFDEPVEMTKDNCR-LLFLRLK-MEGWALGKTKVF--------------------------- 1020
            |....|..|...|..|: ||.:.:| .:.:..||||:|
Zfish   707 LMTKKDLSVGDKKQVCKNLLEILIKDPDKFQFGKTKIFFRAGQVAYLEKLRADKFRFACIKIQKT 771

  Fly  1021 -------LRY------------YNDEFLARLYE------------------LQVKK--------V 1040
                   :||            |...:|||.|.                  :||::        |
Zfish   772 VRGWLQRIRYRKIRKSAITLQRYGRGYLARRYAEMLRLTRAAVICQKQYRMVQVRREYLRVRRAV 836

  Fly  1041 IKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNE 1105
            |.:|:..|.:..|:..   :.|.|      ||  .|..|||..||:        ||.:|. |.:.
Zfish   837 ITIQAFTRGMFIRRLY---QEFLL------HH--KAMIIQKTVRGW--------LVRKKY-QRSR 881

  Fly  1106 NTADFIRPFAKKWREK-SIFQVLLHYRAARF----------------QDFVNLSQQVHIYNQRM- 1152
            ..|..|:.|.::.|.| .:.|:.:..|:|..                :...|.|:::...|:.:
Zfish   882 YAAIVIQCFYRRVRAKRQLKQLKIEARSAEHFKKLNVGMENKIVQLQKKMDNQSKELKSQNENLA 946

  Fly  1153 ---------VAGLNKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPAN 1208
                     |:.|:|     ..|.:..|:|..:|:..|...::|:...|.:...:         .
Zfish   947 VAKTVLETEVSKLSK-----ELETLRTRQVAGTQMTSLQEELEKLRAELQEAHAH---------K 997

  Fly  1209 SISRQAFPN--QLLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYN 1271
            .:..:.|.|  |.|.|.:|:.|..::.|                |||:      :.|........
Zfish   998 KLLEEEFSNEKQGLEQRVEELEKENTVL----------------KKEK------EEMNRRIQTST 1040

  Fly  1272 QGYFRDPQQLRRNQMQMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPS 1336
            |....|..| :.:::|..::.....|.:....|:.............:|:|.:..
Zfish  1041 QDQGGDVSQ-KESRLQHELDDERQRYQNLVKEYSRLEQRYENLQEDMSSMKFHPG---------- 1094

  Fly  1337 SNYYRNNPNQQQRNYQQRSSYP---------PSDPVRELQNMARNEGDNSEDPPFNFKAMLRKTN 1392
               :|.||:.|. :....|:||         ..|.:::::.|...:...........:..:|:..
Zfish  1095 ---HRRNPSNQS-SLGSDSNYPSISLSEVGDTDDTIQQVEEMGIEKAAMDLSVFMKLQKRVRELE 1155

  Fly  1393 YPRGS-ETN---TYDFNNRRGSDSGDQHTFQPPKLRSTGRRYQDDEGYNS------SSGNYGVSR 1447
            ..|.. :||   ..:.:.|:||::         |..::......|..|||      .:.|..:..
Zfish  1156 QERKRLQTNLDKVEELSKRKGSEA---------KNSTSEDDINADLAYNSLKRQELETENKKLKN 1211

  Fly  1448 KFGQQQRAPTLRQSPASVGRSFED------SNARSFEEAGSYVEEEI 1488
            ...:.::|...|.|..:.....:|      |..::..|.....:||:
Zfish  1212 DLNELRKAVADRASENNSSNELQDGYNLLLSQLKAANEELDVRKEEV 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	309/1412 (22%)
		MYSc_Myo21	346..1022	CDD:276848	187/771 (24%)
myo5b	XP_021324561.1	COG5022	7..1371	CDD:227355	306/1408 (22%)
		MYSc_Myo5	83..746	CDD:276831	185/725 (26%)
		Myo5b_CBD	1461..1835	CDD:271261