DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaC and myo9ab

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_021326243.1	Gene:	myo9ab / 562199	ZFINID:	ZDB-GENE-080424-6	Length:	2343	Species:	Danio rerio

Alignment Length:	1045	Identity:	241/1045 - (23%)
Similarity:	419/1045 - (40%)	Gaps:	271/1045 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 KEPELFVDRGYVKRFDEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSN 375
            :|....|:||.:   .:.|...:..||.:|.:..:..::|:||.|......|:::|.||:::|..
Zfish   130 EERRRMVERGLL---PQPPAAQFVADLCSLPDLNEHTMLENLRGRFRQENIYTYVGSILIAVNPF 191

  Fly   376 EIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIK 440
            :....:..::...|......:.:||||:|||.||..||.....|.||:||||.|||:.:...||.
Zfish   192 KFLPIYNPKYVKMYDKHRLGQLEPHIFAVADAAYHAMLQRHRNQCIVISGESGSGKTQSTNFLIH 256

  Fly   441 HLCYLGDGNRGATGRVESSI----KAILMLVNAGTPVNNDSTRCVLQYCLTFGK--------TGK 493
            ||..|  ..:|....||..|    ..:....||.|..||:|:|        |||        :|.
Zfish   257 HLTAL--SQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSR--------FGKFIQVNYQESGT 311

  Fly   494 MSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPS 558
            :.||....|:|||.|:...:..:.|:|:|||.....: :::...::|.....|.||.   ::..|
Zfish   312 VRGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGAS-EDERSXFHLLRPEEYHYLN---QITKS 372

  Fly   559 KLK---------------YRRDDPEGNVERYREFENILRDIDFNHKQLETVRK----VLAAILNI 604
            ..|               ...:|.:.:.||   .:..:..:.|    |.|.||    :|:|||::
Zfish   373 VHKQHWGNHCDTELDCFSVEAEDLKHDFER---LQLAMEMVGF----LPTTRKQIFSLLSAILHL 430

  Fly   605 GNIRFRQ---NGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDA 666
            ||||:::   .....::.|.:::..::|||.|.|:....:||....|..|......|...||...
Zfish   431 GNIRYKKKTFRDDSIDICNPEVLPIVSELLEVKEEMLFEALTTRKTVTVGERLIVPYKLAEAGTV 495

  Fly   667 RDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAII---IHDMFGFECFNRNGLEQLMINTLN 728
            ||::|.:||..|.|:|:.|.|..:.:.:.: .|:..|:   :.|:||||.:..|..||..||..|
Zfish   496 RDSMAKSLYCALFDWIVFRTNHALLYNKDL-EDSAKILSIGVLDIFGFEDYENNSFEQFCINFAN 559

  Fly   729 EQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQ-DQDL 792
            |.:|:::||.:|..|..|..:|.|:...:::.||...::.:..||..|.:::|:.....| ....
Zfish   560 ETLQHYFNQHVFKLEQEEYRSEGINWHMIDYIDNTACINLISKKPTALLHLLDEECNFPQASNQT 624

  Fly   793 IMDRVSEKH--SQFVKKHTATE--ISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSS----- 848
            ::|:...:|  :.:::.....|  ..:.||.|::.|..:.|.:.|.|.:.|:::...:||
Zfish   625 LLDKFKRQHEGNAYMEFPAVMEPAFIIRHYAGKVKYSVKDFREKNTDHLRPDIVSLLKSSRKAFI 689

  Fly   849 -----LDE------SIMLMFTNQLTKAGNLTMPFEAVQHKDES---------------------- 880
                 ||.      :::..|...|     :......:||:|..
Zfish   690 CGLMGLDPVASFRWAVIRAFFRAL-----VAFRHAGLQHRDNRSSGSDVHLQPQKSVDSFSFLHH 749

  Fly   881 ----------------------ERKS--------YALNTLSAG-------------------CIS 896
                                  .|:|        ...||.|:.                   .::
Zfish   750 PVHQRSLEILQRCKDDRYNSCVSRRSPRTPLSDLQGANTFSSNGRGWRSERVSSFAHEDEGIFVN 814

  Fly   897 QVNN----------LR----------------------------------------------TLA 905
            .|||          :|                                              :::
Zfish   815 SVNNRLLERAQGILMRNKNYKPKPSLPKHLLDVKSLKYLSSLTLHDRITKSLLHLHKKKKPPSIS 879

  Fly   906 ANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFS 970
            |.|..:...|::.|.|:.   .:||:|||::.|..|..|:..:|.:|::..|:|:||..||.|:|
Zfish   880 AQFNVSLNKLMETLGQSE---PYFVKCIRSNAEKLPLRFNDALVLRQLRYTGMLETVRIRQSGYS 941

  Fly   971 SRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLL-FLR---LKMEGWALGKTKVFL-----RYYND 1026
            .:..|.:|...:..|.     |...:.....:. |||   |:..|:.:|::.|||     :...|
Zfish   942 VKYSFKDFAHHFHVLL-----PAGFSASQMGIREFLRSADLEPSGYQVGRSMVFLHERLRQRLQD 1001

  Fly  1027 EFLARLYELQVKKVIKVQSMMRALLARKRV--------------------KGGKVFKLGKKGPEH 1071
            |    |::..:::::.:|...|....||..                    ..|.|..|     |.
Zfish  1002 E----LHQEVLRRIVCLQRSFRTQRDRKHFCRQRRAARLIQRWWRSCISQADGSVCAL-----EL 1057

  Fly  1072 HDVAASKIQKAFRGFRDR-----VRLPPLVNEKSGQ--LN-ENTADFIRPFAKKWREKSIFQVLL 1128
            ...||.::|..:||||.|     .|...|:.::..:  || .|||..:  ....||.::..:..|
Zfish  1058 QQGAALRLQAVWRGFRARRLYLQQRRAVLIIQRCWRRVLNTRNTAATL--IQAVWRTRTHRRSFL 1120

  Fly  1129 HYRAA 1133
            ..|.|
Zfish  1121 QQRRA 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		S_TKc	16..282	CDD:214567
		MYSc	327..1034	CDD:214580	209/900 (23%)
		MYSc_Myo21	346..1022	CDD:276848	202/869 (23%)
myo9ab	XP_021326243.1	UBQ	7..111	CDD:320785
		MYSc_Myo9	163..991	CDD:276836	200/862 (23%)
		C1	1793..1841	CDD:237996
		RhoGAP_myosin_IXA	1854..2039	CDD:239871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900