Protein Alignment ninaC and MYO5C

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_061198.2
• Gene: MYO5C / 55930
• HGNCID: 7604
• Length: 1742
• Species: Homo sapiens
• Alignment Length: 1101
• Identity: 269/1101 - (24%)
• Similarity: 468/1101 - (42%)
• Gaps: 183/1101 - (16%)

  Fly   295 DIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAALENP---VDENIIESLRH-- 354
            ::.:..|:::|.:...|...|.::.|     .|....:.||.|..|.||   |.||.:.:|.:
Human    20 EVWKSAEIAKDYRVGDKVLRLLLEDG-----TELDYSVNPESLPPLRNPDILVGENDLTALSYLH 79

  Fly   355 --------RILMGES---YSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIA 408
                    ||...||   |::.|.||:::|..:....:.......|..::..:..||||:||:.|
Human    80 EPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPHIFAVAEEA 144

  Fly   409 YQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLV----NA 469
            |:.|..:...|.|::||||.:||:.:||..:::...:  ...|:...||..:.|...:.    ||
Human   145 YKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATV--SKSGSNAHVEDKVLASNPITEAVGNA 207

  Fly   470 GTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQ 534
            .|..|::|:|......::|.:..::.||..:.|:|||.||......:.|:||||...... ||::
Human   208 KTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIFYQLCASA-QQSE 271

  Fly   535 LKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLA 599
            .|...|.:...:.|.|:........:..|.:    .||..:.|..:....||   |:: |.|:||
Human   272 FKHLKLGSAEEFNYTRMGGNTVIEGVNDRAE----MVETQKTFTLLGFKEDF---QMD-VFKILA 328

  Fly   600 AILNIGNIRFRQ--NGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEE 662
            |||::||::...  |.:.:..|:...:....|||.::..:....|.|..:|.......:..|..:
Human   329 AILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQ 393

  Fly   663 ARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAII-IHDMFGFECFNRNGLEQLMINT 726
            |.:||||:|..:|:.|.|||:.|||..:.|.    |..:..| :.|::|||.|:.|..||..||.
Human   394 AVNARDALAKKIYAHLFDFIVERINQALQFS----GKQHTFIGVLDIYGFETFDVNSFEQFCINY 454

  Fly   727 LNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSC---- 787
            .||::|..:|..:|..|..|...|||....::||||:..:| |:....|:..::|:   .|
Human   455 ANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVID-LIEAKMGILELLDE---ECLLPH 515

  Fly   788 -QDQDLIMDRVSEKHSQFVKKH--------TATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIE 843
             .|::.:    .:.::.||.::        :.|...:.|:..::.|....|.:.|||.|...::|
Human   516 GTDENWL----QKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVE 576

  Fly   844 TFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLR---TLA 905
            ..|:|........|....|...    ||.::            :...||..:.:.|:..   |:.
Human   577 ILRASKFHLCANFFQENPTPPS----PFGSM------------ITVKSAKQVIKPNSKHFRTTVG 625

  Fly   906 ANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFS 970
            :.||.:...|::.|:...   .|:||||:.:.|..|..|.|..:.||::|.|||:|:....:.:.
Human   626 SKFRSSLYLLMETLNATT---PHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYP 687

  Fly   971 SRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLRLKMEG--WALGKTKVFLRYYNDEFLARLY 1033
            ||..:.||..||..|....:......|:.|:::..||..:.  :..||||:|.|...   :|.|.
Human   688 SRWTYIEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQ---VAYLE 749

  Fly  1034 ELQVKKV----IKVQSMMRALLARKRV----KGGKVFKLGKKGPE-----------HHDVAASKI 1079
            :|::.|:    :.||..||..|.||:.    :...:.:...:|.:           ....||..|
Human   750 KLRLDKLRQSCVMVQKHMRGWLQRKKFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIII 814

  Fly  1080 QKAFRGFRDR-----VRLPPLVNEKSGQ-----------LNENTADFIRPFAKKWREKSIFQ--- 1125
            ||..||:..|     :|:..:..:...:           |.|:.|..::.:|:.|..:..||
Human   815 QKHCRGYLVRSLYQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIR 879

  Fly  1126 -----VLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNK--CTRAVPFERINMREVNSSQLGPLPV 1183
                 :.|.||..|.|.  .|..| :..|..:|..|..  ..||...|:
Human   880 RFVLNIQLTYRVQRLQK--KLEDQ-NKENHGLVEKLTSLAALRAGDVEK---------------- 925

  Fly  1184 PIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQL--LTQHMEDDEPWDSPLQRNPSMTSCALT 1246
             |:|:...|::...:...|  :......|.|...:|  |.:|..:.|.....:|
Human   926 -IQKLEAELEKAATHRRNY--EEKGKRYRDAVEEKLAKLQKHNSELETQKEQIQ----------- 976

  Fly  1247 YNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYNSYNSNYNNQ 1307
               .|.::..:...::|   ||:..| .|.|.|:..|.:|.:     ..::.....:|..|
Human   977 ---LKLQEKTEELKEKM---DNLTKQ-LFDDVQKEERQRMLL-----EKSFELKTQDYEKQ 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	191/713 (27%)
MYO5C	NP_061198.2	MYSc_Myo5	81..741	CDD:276831	188/701 (27%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	632..654		7/24 (29%)
		IQ	810..828	CDD:197470	8/17 (47%)
		IQ	831..851	CDD:459869	1/19 (5%)
		SMC_prok_B	<886..>1356	CDD:274008	36/185 (19%)
		Myo5c_CBD	1369..1736	CDD:271260