Protein Alignment ninaC and myo10

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001362203.1
• Gene: myo10 / 548806
• XenbaseID: XB-GENE-1018818
• Length: 2086
• Species: Xenopus tropicalis
• Alignment Length: 1253
• Identity: 317/1253 - (25%)
• Similarity: 525/1253 - (41%)
• Gaps: 238/1253 - (18%)

  Fly   327 EKPEKMYP------EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLN----------SN 375
            :|...::|      ||:|||.:..:.:|:.:|..|....:.|::||.||.|:|          .|
 Frog    52 QKVTSIHPTSADGVEDMAALSDLHEGSIMYNLFQRYQQNKIYTYIGSILASVNPYKMIAGLYDCN 116

  Fly   376 EIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIK 440
            .:      |.::::..   .|..||||:||...|:.:....:.|.:::||||.:||:.:.:|::|
 Frog   117 AV------ELYSRHHM---GEIPPHIFAVASECYRCLWKRHDNQCVLISGESGAGKTESTKLILK 172

  Fly   441 HLCYLGD-----GNRGATGRVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLTFGK------ 490
            .|..:..     .::..|..||.:|.....::    ||.|..||:|:|        |||
 Frog   173 FLSAMSQHSLEISSKEKTASVEQAILESSPIMEAFGNAKTVYNNNSSR--------FGKFIQLNI 229

  Fly   491 --TGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPP 553
              .|.:.|.....|:|||.||...:..:.|:||||...:...::.:...|.|:|:: |.||....
 Frog   230 CQKGHIQGGRIVDYLLEKNRVVRQNPEERNYHIFYALLEGAGKEERDAFYLLQAEK-YHYLNQSG 293

  Fly   554 EVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGKYAEV 618
            .:        .|:...:.|.::|.:..:..:.|:.:::..:.::||.||::||:.|...|. |::
 Frog   294 CI--------LDETISDHETFQEVKAAMEVMKFSREEVREIFRLLAGILHLGNMEFITAGG-AQI 349

  Fly   619 ENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFII 683
            .:...:.|.:|||.:|.::...:||...|:..|.......:.|:|.|:||:||..|||:...::|
 Frog   350 SSKTALGRASELLGLDSEQMAEALTQRSMILRGEEISTPLSVEQAVDSRDSVAMALYSQCFAWVI 414

  Fly   684 NRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEME 748
            .:||..:...    .|..:|.|.|:||||.|..|..||..||..||::|.::|:.||..|.||..
 Frog   415 MKINSRIKGK----DDFKSIGILDIFGFENFEVNRFEQFNINYANEKLQEYFNKHIFSLEQLEYS 475

  Fly   749 AEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQD-LIMDRVSEKHSQ---FVKKHT 809
            .|.:....:::.||...|| |:.|..||..:|::.|...|..| .:::::.::|:.   :||...
 Frog   476 REGLAWNAIDWIDNGECLD-LIEKKLGLLALINEESYFPQATDNTLLEKLHKQHANNHFYVKPRV 539

  Fly   810 AT-EISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFR-SSLDESIMLMFTNQLTKAGNLTMPFE 872
            |. ...|.||.|.::||.|...:.|||....:::...| ||||      |...|         ||
 Frog   540 AVHNFGVKHYAGEVLYDVRGTLEKNRDTFRDDLLNLLRESSLD------FIYDL---------FE 589

  Fly   873 AVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADL 937
            .|..::..|       ||.:|   ..:...|::..|:.:..:|:..||.:   ...|||||:.::
 Frog   590 HVSSRNNQE-------TLKSG---NKHKKPTVSLQFKDSLHSLMAKLSTS---NPFFVRCIKPNI 641

  Fly   938 EYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCR- 1001
            ...|..|...||..|::..|:|:||..|:.||..|..|::|..||:.|..:...|.:| |..|.
 Frog   642 HKMPDQFDDTVVLNQLRYSGMLETVRIRKAGFPVRRLFNDFCFRYKVLMKNLSLPEDM-KGKCEV 705

  Fly  1002 LLFLRLKME-GWALGKTKVFLRYYNDEFLARLYELQV-KKVIKVQSMMRALLARKRVKGGKVFKL 1064
            ||.|....: .|.:||||||||...:..|.:..:::| |..:.:|:.:...:|||:.|  ||.
 Frog   706 LLHLHDNTDTEWQIGKTKVFLRESLEHKLEKQRDIEVFKAALIIQAHIMGFVARKQYK--KVL-- 766

  Fly  1065 GKKGPEHHDVAASKIQKAFRGF---RDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQV 1126
                     .....|||.:|.|   |..:||.........||....|   |...|:.||:.  |.
 Frog   767 ---------YCVVVIQKNYRAFLWRRKFLRLKKAAVTFQRQLRGQIA---RRIYKQLREQK--QR 817

  Fly  1127 LLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFR 1191
            ....|..:.::.....::.....:.....|.|.......| |..||.:..:...|....::...:
 Frog   818 EEEERRRKEEEERKKKEEEERRRREEEERLRKEEERKKKE-IEERERHRQEEETLAKQAEEARKQ 881

  Fly  1192 LDQIPFYDTQYMVDPANSISRQAFPNQ---LLTQHMEDDEPWDSPLQRNPSMTSCALTY------ 1247
            .:.....:.|    ..|.|.:|....|   :|....|.|:     |||.......:||.
 Frog   882 QELAAMLEAQ----NHNEIDKQKENKQVEEILRLEKEIDD-----LQRQKEKQELSLTEASLQRL 937

  Fly  1248 -----NAYKK--EQACQT--------NWDRMGE-----------SD------NI----------- 1269
                 |..|:  |:||:.        |:|.:.|           ||      ||
 Frog   938 QELRDNELKRLEEEACRAAQEFLESLNFDEIDECVKNIEMSLSVSDVFPELSNIPGVSSTKPSFN 1002

  Fly  1270 YNQGYFRDPQQLRRNQMQMNMNAYNNAYNSYNSNYNNQNW-GVHRS--GSRRNSLKGYAAPPPPP 1331
            ::|.|   |::......:.:..|:.::.|.....:::|.. |:..|  .|..:....|..  ..|
 Frog  1003 FSQPY---PEEEVDEGFEADDEAFKDSPNPSEHGHSDQRTSGIRTSDDSSEEDPYMNYTV--GGP 1062

  Fly  1332 PPMPSSNYY----RNNPNQQQRNYQQRSSYPPSDPVRELQN---MARNEGDNSEDPPFNFKAMLR 1389
            |...:||..    .|..|.::....:.:...|.:...|.||   :...:||...|
 Frog  1063 PQAATSNKLLSLDENKANVKKLTSGESTYCVPENAPCEPQNPGSIIIPDGDYDYD---------- 1117

  Fly  1390 KTNYPRGSETNTYDFNNRRGSDSGDQHTFQPPKLRSTGRRYQDDEGYNSSSGNYGVSRKFGQQQR 1454
            ..:|..|:.|            ||...||.    .|...::..|  ||.|.|.|..|..:
 Frog  1118 HDDYEDGAIT------------SGSSVTFS----NSVSSQWSPD--YNFSLGTYNGSSAY----- 1159

  Fly  1455 APTLRQSPASVGRSFEDS 1472
                |.|......|||||
 Frog  1160 ----RFSSEGAQSSFEDS 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	204/710 (29%)
myo10	NP_001362203.1	SH3_19	7..58	CDD:465815	1/5 (20%)
		MYSc_Myo10	77..727	CDD:276840	204/710 (29%)
		IQ	744..763	CDD:459869	5/18 (28%)
		SMC_N	871..>976	CDD:481474	22/113 (19%)
		MYO10_CC	901..951	CDD:465249	11/54 (20%)
		PH-like	<1210..>1237	CDD:473070
		PH2_MyoX	1240..1341	CDD:270108
		PH3_MyoX-like	1406..1531	CDD:270109
		MyTH4	1574..1720	CDD:214535
		FERM_F1_Myosin-X	1722..1817	CDD:340726
		B41	1729..1983	CDD:214604
		FERM_C_MyoX	1979..2067	CDD:270023