DRSC/TRiP Functional Genomics Resources

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Protein Alignment ninaC and MYO3A

DIOPT Version :9

Sequence 1:NP_523503.2 Gene:ninaC / 34012 FlyBaseID:FBgn0002938 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_059129.3 Gene:MYO3A / 53904 HGNCID:7601 Length:1616 Species:Homo sapiens


Alignment Length:1660 Identity:493/1660 - (29%)
Similarity:741/1660 - (44%) Gaps:330/1660 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 YAQLPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQV--SIEEEYRTLRDYC 68
            :...|||:|.:||.|.|.:|...|||:.....|.:..|:||  .|..|.:  .||.||..|:...
Human    11 FDNFPDPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALS 73

  Fly    69 DHPNLPEFYGVY-KLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRA 132
            ||||:..|||:| |..|.|| |::|.|:|.|:||:..|:|...||...||.|..||||:.|....
Human    74 DHPNVVRFYGIYFKKDKVNG-DKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMG 137

  Fly   133 AIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMES 197
            ...|:.|..:|||::|:|||||..|.|||.|||:|.|:.||..:|.|.:|:|.||||||::..:.
Human   138 LQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQ 202

  Fly   198 REPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISES 262
            .:.....|.|.|:||||.|||.||.||.||:||.||:|:|.|||||.|.:|..||.:.|||||:.
Human   203 LDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKC 267

  Fly   263 LEKNAENRPMMVEMVEHPFLTELIENEDEM-RSDIAEMLELSRDVKTLYK--EPELFVDRGYVKR 324
            |.|:.|.||.:.|:::|.|:|: ||.:|.| :..:.|.:.:.:.:....|  ...:...:|...|
Human   268 LTKDYEKRPTVSELLQHKFITQ-IEGKDVMLQKQLTEFIGIHQCMGGTEKARRERIHTKKGNFNR 331

  Fly   325 FDEKPEKMYP--------EDLAALENPVDENII-ESLRHRILMGESYSFIGDILLSLNSNEIKQE 380
                     |        :|||.|| .:|||.: |.|.......:.|.::||||::||..:....
Human   332 ---------PLISNLKDVDDLATLE-ILDENTVSEQLEKCYSRDQIYVYVGDILIALNPFQSLGL 386

  Fly   381 FPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYL 445
            :..:....|....|:.:.||||::||:.||.|:.:...|.||:||||.:||:.||.||::.|..|
Human   387 YSTKHSKLYIGSKRTASPPHIFAMADLGYQSMITYNSDQCIVISGESGAGKTENAHLLVQQLTVL 451

  Fly   446 GDGNRGATGRVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEK 506
            |..|...   ::..|..:..||    ||.|.:|::|:|......:.|..:|.:.||..:.|:|||
Human   452 GKANNRT---LQEKILQVNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEK 513

  Fly   507 LRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNV 571
            .||......:.|||||||.|..:.::.:|..|.|           |...||   :|.::|....|
Human   514 SRVIHQAIGEKNFHIFYYIYAGLAEKKKLAHYKL-----------PENKPP---RYLQNDHLRTV 564

  Fly   572 E----------RYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDI--- 623
            :          :|...|...:.|.|..:||.::..:||||||:|||.|.......:::.:.|   
Human   565 QDIMNNSFYKSQYELIEQCFKVIGFTMEQLGSIYSILAAILNVGNIEFSSVATEHQIDKSHISNH 629

  Fly   624 --VSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRI 686
              :...|.||.:...:...:||:..:|..|....|..|.|:|.|.|||:|.|||.||..:|:|.|
Human   630 TALENCASLLCIRADELQEALTSHCVVTRGETIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCI 694

  Fly   687 NMNM---SFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEME 748
            |..:   |.|.. .||..:|.|.|:||||.|.:|..|||.||..|||:||:|||.:|..|..|..
Human   695 NSLLKHDSSPSG-NGDELSIGILDIFGFENFKKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYL 758

  Fly   749 AEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASR--SCQDQDLIMDRVSEKHSQFVKKHTAT 811
            .||:|...:.:.||...||..|.||.||..::|:.||  ...||.|:........||:..:....
Human   759 NEDVDARVIEYEDNWPLLDMFLQKPMGLLSLLDEESRFPKATDQTLVEKFEGNLKSQYFWRPKRM 823

  Fly   812 EIS--VAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQ-LTKAGNLTMPFEA 873
            |:|  :.||.|:::|:...|...|||.:|.:::...||| |.|::....|. |||.|||  |...
Human   824 ELSFGIHHYAGKVLYNASGFLAKNRDTLPTDIVLLLRSS-DNSVIRQLVNHPLTKTGNL--PHSK 885

  Fly   874 VQHK-DESERKSYALNTLSAGCIS-------QVNNLR--TLAANFRFTCLTLL-KMLSQNANLGV 927
            .::. :...|.|..|..|:.|...       :..|::  |:|:.||::.:.|| ||:....    
Human   886 TKNVINYQMRTSEKLINLAKGDTGEATRHARETTNMKTQTVASYFRYSLMDLLSKMVVGQP---- 946

  Fly   928 HFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEP 992
            ||||||:.:.|.:.|.:..:.|..|::..|:|:|...|:.|||.|:.|..|::||..|.:...|.
Human   947 HFVRCIKPNSERQARKYDKEKVLLQLRYTGILETARIRRLGFSHRILFANFIKRYYLLCYKSSEE 1011

  Fly   993 VEMTKDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVK 1057
            ..|:.|.|..:..:..::.||||||||||:||:.|.|..:.:..:.|:|.:|:.:||.|..:|.:
Human  1012 PRMSPDTCATILEKAGLDNWALGKTKVFLKYYHVEQLNLMRKEAIDKLILIQACVRAFLCSRRYQ 1076

  Fly  1058 GGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLN---------------ENT 1107
                 |:.:|..|    :|..||.|.||...|.:...:|:.|:..:.               |||
Human  1077 -----KIQEKRKE----SAIIIQSAARGHLVRKQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENT 1132

  Fly  1108 ADFIRPFAKKWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAV--------- 1163
            .:   .|.||..|.:|      ....||....|....|.:..........:.|.||         
Human  1133 RE---SFVKKQAENAI------SANERFISAPNNKGSVSVVKTSTFKPEEETTNAVESNNRVYQT 1188

  Fly  1164 PFERINMREVNSSQ----LGPLPVPIKKMPFRLDQ-------------IPFYDTQYMVDPANSIS 1211
            |.:..|:.|....|    :||...|.:|....|::             |..|..:|..:.....|
Human  1189 PKKMNNVYEEEVKQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEES 1253

  Fly  1212 RQAF-PNQLLTQHMEDDEPWDSPLQRN---------PSMTSCALTYNAYKKEQACQTN------- 1259
            :.|: ..:.:::......||   |..|         |:::..::..||...|:..:|:       
Human  1254 KAAYLERKAISERPSYPVPW---LAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQRAP 1315

  Fly  1260 ------------------------WDRMGESDN--IYNQGYFRD---PQQLRRNQMQM------- 1288
                                    .....|.|.  ::.|..:|.   .||||:::|..       
Human  1316 ICSQEEGRGRLRHETVKERQVEPVTQAQEEEDKAAVFIQSKYRGYKRRQQLRKDKMSSFKHQRIV 1380

  Fly  1289 -----------NMNAYNNAYNSYNSNYNNQN---------------------------------- 1308
                       |:.:|...:...|:.....|                                  
Human  1381 TTPTEVARNTHNLYSYPTKHEEINNIKKKDNKDSKATSEREACGLAIFSKQISKLSEEYFILQKK 1445

  Fly  1309 --------------WGV--HRSGSRRNS----LKGYAAPPPP----PPPMPSSNYYRNNPNQQ-- 1347
                          .||  |:..:||.|    |.|......|    ||..|......|||...  
Human  1446 LNEMILSQQLKSLYLGVSHHKPINRRVSSQQCLSGVCKGEEPKILRPPRRPRKPKTLNNPEDSTY 1510

  Fly  1348 ----QRNYQQRSSYPPSD----------------------------------PVRELQNMA---- 1370
                .::.|:....|..|                                  |.:||||..    
Human  1511 YYLLHKSIQEEKRRPRKDSQGKLLDLEDFYYKEFLPSRSGPKEHSPSLRERRPQQELQNQCIKAN 1575

  Fly  1371 -------RNEGDNSEDP---PFNFKAMLRKTNYPR 1395
                   ..|.:...:|   |::|:.:||||:..|
Human  1576 ERCWAAESPEKEEEREPAANPYDFRRLLRKTSQRR 1610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ninaCNP_523503.2 STKc_myosinIII_N_like 9..282 CDD:270785 129/275 (47%)
S_TKc 16..282 CDD:214567 125/268 (47%)
MYSc 327..1034 CDD:214580 252/753 (33%)
MYSc_Myo21 346..1022 CDD:276848 240/714 (34%)
MYO3ANP_059129.3 STKc_myosinIIIA_N 2..287 CDD:132969 129/278 (46%)
S_TKc 21..287 CDD:214567 125/268 (47%)
MYSc 337..1053 CDD:214580 251/741 (34%)
MYSc_Myo3 352..1041 CDD:276830 239/713 (34%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 934..956 10/25 (40%)
Interaction with MORN4. /evidence=ECO:0000269|PubMed:25822849 1401..1479 8/77 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1545..1567 1/21 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1581..1616 9/30 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H49486
Inparanoid 1 1.050 622 1.000 Inparanoid score I877
Isobase 1 0.950 - 0 Normalized mean entropy S3935
OMA 1 1.010 - - QHG52654
OrthoDB 1 1.010 - - D25137at33208
OrthoFinder 1 1.000 - - FOG0003766
OrthoInspector 1 1.000 - - otm40427
orthoMCL 1 0.900 - - OOG6_104503
Panther 1 1.100 - - O PTHR46256
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2623
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.930

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