Protein Alignment ninaC and MYO15A

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_016880204.1
• Gene: MYO15A / 51168
• HGNCID: 7594
• Length: 3531
• Species: Homo sapiens
• Alignment Length: 1243
• Identity: 310/1243 - (24%)
• Similarity: 518/1243 - (41%)
• Gaps: 296/1243 - (23%)

  Fly   324 RFDEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAK 388
            ||.|:..:...||:..||:..:..::.:|:.|......|::||.||:|:|..::...:..|...:
Human  1214 RFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPEQVQQ 1278

  Fly   389 YRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGAT 453
            |..::..||.||:|:||::|:..||..|:.|.|::||||.|||:...:|::::|..:.. .|...
Human  1279 YNGRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQ-KREVM 1342

  Fly   454 GRVESSIKAILMLV---NAGTPVNNDSTRCVLQYCLTFGK-------TGKMSGAVFNMYMLEKLR 508
            .:|...::|..:|.   ||.|..|::|:|        |||       .|.:|||:.:.|:|||.|
Human  1343 QQVIQILEATPLLESFGNAKTVRNDNSSR--------FGKFVEIFLEGGVISGAITSQYLLEKSR 1399

  Fly   509 VATTDGTQHNFHIFYYFYDFINQQNQLKE-YNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVE 572
            :......:.|:||||..  ......||:: ::|:....|.||                :..||.|
Human  1400 IVFQAKNERNYHIFYEL--LAGLPAQLRQAFSLQEAETYYYL----------------NQGGNCE 1446

  Fly   573 --------RYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGKY-------AEVENTD 622
                    .:|.....:..:.|:.:..:::.::||:||::||:.|.   ||       |.|.:..
Human  1447 IAGKSDADDFRRLLAAMEVLGFSSEDQDSIFRILASILHLGNVYFE---KYETDAQEVASVVSAR 1508

  Fly   623 IVSRIAELLRVDEKKFMWSLTNFIMVKGGIAER--RQYTTEEARDARDAVASTLYSRLVDFIINR 685
            .:..:||||::..:....::|  ..|...:.|:  ...|.|.|.|||||:|..||:.|..::|.|
Human  1509 EIQAVAELLQISPEGLQKAIT--FKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITR 1571

  Fly   686 INMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAE 750
            :|..:| ||.   ||.:|.|.|::|||..:.|..|||.||..||.:||.:|:.:|..|..|...|
Human  1572 VNALVS-PRQ---DTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIRE 1632

  Fly   751 DIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIMDRVSEKHSQFVKK----HTAT 811
            .||...:.|.||:..::.:..||.|:..|:||  :.|..|       :..|: |::|    |.|.
Human  1633 QIDWQEITFADNQPCINLISLKPYGILRILDD--QCCFPQ-------ATDHT-FLQKCHYHHGAN 1687

  Fly   812 -----------EISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAG 865
                       |.::.||.|::.|....|.|.|.|.|..::::.|..|....:..:|::...:|
Human  1688 PLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVRSRTRVVAHLFSSHAPQA- 1751

  Fly   866 NLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFV 930
                   |.|...:|            ..::::....|:||.|:.:.|.|::.:.:...|   |:
Human  1752 -------APQRLGKS------------SSVTRLYKAHTVAAKFQQSLLDLVEKMERCNPL---FM 1794

  Fly   931 RCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL-AFDFDEPVE 994
            ||::.:.:.:|..|..|||..|::..|||:||..|::||..||||..|:.||..| |...|.|.
Human  1795 RCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCCLVALKHDLPA- 1858

  Fly   995 MTKDNCRLLFLRL---KMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRV 1056
             ..|.|..:..||   ....:.:|.:|:||:.:       ||:|       ::||...:|
Human  1859 -NGDMCVSVLSRLCKVMPNMYRVGVSKLFLKEH-------LYQL-------LESMREHVL----- 1903

  Fly  1057 KGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREK 1121
                            ::||..:|:..|||                       ||:...:..|.|
Human  1904 ----------------NLAALTLQRCLRGF-----------------------FIKRRFRSLRHK 1929

  Fly  1122 SIFQVLLHYRA------ARFQ----DFVNLSQQVHIYNQR------------MVAGLNKCTRAVP 1164
            .|   ||..||      .|:|    ..|.....||.|..|            .|.|      |:.
Human  1930 II---LLQSRARGYLARQRYQQMRRSLVKFRSLVHAYVSRRRYLKLRAEWRCQVEG------ALL 1985

  Fly  1165 FER--INMREVNSSQLGPLPVPIK-------KMPFRLDQIPFYDTQYMVDPANSISRQAFPN--- 1217
            :|:  ::.|||.:  :|.|.||.:       .....|.|:|      .|.|..:...||.|.
Human  1986 WEQEELSKREVVA--VGHLEVPAELAGLLQAVAGLGLAQVP------QVAPVRTPRLQAEPRVTL 2042

  Fly  1218 ----------QLLTQHMEDDE------PWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGES 1266
                      :.:..|.::..      |..:||.:.|: ...|...:.:|.......:....|..
Human  2043 PLDINNYPMAKFVQCHFKEPAFGMLTVPLRTPLTQLPA-EHHAEAVSIFKLILRFMGDPHLHGAR 2106

  Fly  1267 DNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPP 1331
            :||:.....:....:...:.::.....|..::::|::...:.|.:..:     .|.|:|
Human  2107 ENIFGNYIVQKGLAVPELRDEILAQLANQVWHNHNAHNAERGWLLLAA-----CLSGFA------ 2160

  Fly  1332 PPMPS---------SNYYRNNPNQQQRNYQQRSSYPPSDPVRELQNMARNEGDNSEDPPFNFKAM 1387
             |.|.         |:|.||       .:|....:      |.:|.|.|.:...|.
Human  2161 -PSPCFNKYLLKFVSDYGRN-------GFQAVCQH------RLMQAMGRAQQQGSG--------- 2202

  Fly  1388 LRKTNYPRGSE-TNTYDFNNRR---GSDSGDQHTFQPPKLRSTGRRYQDD----EGYNSSSGNYG 1444
            ..:|..|...| |.||:..:..   |..:|||.:. |....|||.....|    .|.......:.
Human  2203 AARTLPPTQLEWTATYEKASMALDVGCFNGDQFSC-PVHSWSTGEEVAGDILRHRGLADGWRGWT 2266

  Fly  1445 VSRKFGQQ 1452
            |:.|.|.|
Human  2267 VAMKNGVQ 2274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	207/722 (29%)
MYO15A	XP_016880204.1	SGP	<320..364	CDD:435798
		PHA03247	<723..1144	CDD:223021
		MYSc_Myo15	1236..1888	CDD:276838	207/722 (29%)
		IQ	1926..1947	CDD:197470	8/23 (35%)
		MyTH4	2066..2218	CDD:214535	31/186 (17%)
		PHA03247	<2433..2673	CDD:223021
		SH3_MYO15A	2872..2951	CDD:213000
		MyTH4	3051..3205	CDD:214535
		FERM_M	3300..3420	CDD:459788
		FERM_C_MyoXV	3416..3517	CDD:270022