DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaC and MINK1

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_006721594.1	Gene:	MINK1 / 50488	HGNCID:	17565	Length:	1361	Species:	Homo sapiens

Alignment Length:	414	Identity:	140/414 - (33%)
Similarity:	223/414 - (53%)	Gaps:	41/414 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQVSIEEEYRTLRDYCDHPNL 73
            |.||...||:.|.:..|...:|::.:.:...::.|:|:....|:.:..|::|...|:.|..|.|:
Human    18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNI 82

  Fly    74 PEFYGVY-KLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRAAIELN 137
            ..:||.: |.|.|...|::|.|||:|..|:..|:|..  .....::|:.||||.||..|....|:
Human    83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN--TKGNALKEDCIAYICREILRGLAHLH 145

  Fly   138 RNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMESREPDI 202
            .:.|:||||:|.|:|||:|..|||.|||:|.|:|.|:|:|.|.||:|.||||||::..|:.:...
Human   146 AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATY 210

  Fly   203 TVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISESLEKNA 267
            ..|:|:|:||||.||:|:|.||..||||.||:|.|.|||||.| :...||::..|||...|.|..
Human   211 DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTY 274

  Fly   268 ENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKM 332
            .:||...::::.||:.:. ..|.::|..:.:.::.||. |...||...:...|..:..|...|:.
Human   275 LSRPPTEQLLKFPFIRDQ-PTERQVRIQLKDHIDRSRK-KRGEKEETEYEYSGSEEEDDSHGEEG 337

  Fly   333 YPEDLAALENPVDENII--ESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRS 395
            .|   :::.|...|:.:  |.||   |..|:.|         ||..:||:        .:.:.:.
Human   338 EP---SSIMNVPGESTLRREFLR---LQQENKS---------NSEALKQQ--------QQLQQQQ 379

  Fly   396 ENQP--HIFSVADIAYQDMLHHKE 417
            :..|  ||        :.:||.::
Human   380 QRDPEAHI--------KHLLHQRQ 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	111/273 (41%)
		S_TKc	16..282	CDD:214567	108/266 (41%)
		MYSc	327..1034	CDD:214580	19/95 (20%)
		MYSc_Myo21	346..1022	CDD:276848	16/76 (21%)
MINK1	XP_006721594.1	STKc_MAP4K4_6_N	8..289	CDD:270806	111/273 (41%)
		S_TKc	25..289	CDD:214567	108/266 (41%)
		CNH	1043..1341	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810