Protein Alignment ninaC and Myo15a

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001414755.1
• Gene: Myo15a / 501699
• RGDID: 1561873
• Length: 3512
• Species: Rattus norvegicus
• Alignment Length: 1166
• Identity: 295/1166 - (25%)
• Similarity: 495/1166 - (42%)
• Gaps: 279/1166 - (23%)

  Fly   335 EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQP 399
            ||:..||:..:..::.:|:.|......|::||.||:|:|...:...:..|...:|..::..||.|
  Rat  1214 EDMTQLEDLQETTVLTNLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALGENPP 1278

  Fly   400 HIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAIL 464
            |:|::|::|:..||..|:.|.:::||||.|||:...:||::  |......|....:....::|..
  Rat  1279 HLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLLLR--CLAAMNQRRDVMQQIKILEATP 1341

  Fly   465 MLV---NAGTPVNNDSTRCVLQYCLTFGK-------TGKMSGAVFNMYMLEKLRVATTDGTQHNF 519
            :|.   ||.|..|::|:|        |||       .|.:.||:.:.|:|||.|:......:.|:
  Rat  1342 LLEAFGNAKTVRNDNSSR--------FGKFVEIFLEGGVICGAITSQYLLEKSRIVFQAKNERNY 1398

  Fly   520 HIFYYFYDFINQQNQLKE-YNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVE--------RYR 575
            ||||..  ......||:: ::|:....|.||                :..||.|        .:|
  Rat  1399 HIFYEL--LAGLPAQLRQAFSLQEAETYYYL----------------NQGGNCEIAGKSDADDFR 1445

  Fly   576 EFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQN----GKYAEVENTDIVSRIAELLRVDEK 636
            .....:..:.|..:..:::.::||:||::||:.|.::    .:.|.|.:...:..:||||:|..:
  Rat  1446 RLLAAMEVLGFTSEDQDSIFRILASILHLGNVYFEKHETDAQEVASVVSAREIQAVAELLQVSPE 1510

  Fly   637 KFMWSLTNFIMVKGGIAER--RQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGD 699
            ....::|  ..|...|.|:  ...|.|.|.|||||:|..||:.|..::|.|:|..:| |:.   |
  Rat  1511 GLQKAIT--FKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVS-PKQ---D 1569

  Fly   700 TNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKT 764
            |.:|.|.|::|||..:.|..|||.||..||.:||.:|:.:|..|..|...|.:|...:.|.||:.
  Rat  1570 TLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQP 1634

  Fly   765 ALDNLLTKPDGLFYIIDDASRSCQDQDLIMDRVSEKHSQFVKK----HTAT-----------EIS 814
            .::.:..||.|:..|:||  :.|..|       :..|: |::|    |.|.           |.:
  Rat  1635 CINLISLKPYGILRILDD--QCCFPQ-------ATDHT-FLQKCHYHHGANPLYCKPKMPLPEFT 1689

  Fly   815 VAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTN--------QLTKAGNLTMPF 871
            :.||.|::.|....|.|.|.|.|..::::.|..|....:..:|::        :|.|:.::|..:
  Rat  1690 IKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLY 1754

  Fly   872 EAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRAD 936
            :|                            .|:||.|:.:.|.|::.:.:...|   ||||::.:
  Rat  1755 KA----------------------------HTVAAKFQQSLLDLVEKMERCNPL---FVRCLKPN 1788

  Fly   937 LEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL-AFDFDEPVEMTKDNC 1000
            .:.:|..|..||:..|::..|||:||..|::||..||||..|:.||:.| |...:.|.:  .|.|
  Rat  1789 HKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALKLNVPAD--GDMC 1851

  Fly  1001 RLLFLRL---KMEGWALGKTKVFL------------------------RYYNDEFLARLYELQVK 1038
            ..|..||   ..:.:.:|.:|:||                        ||....|..|.:....:
  Rat  1852 VSLLSRLCTVTPDMYRVGVSKLFLKEHLHQLLESMRERVLNRAALTLQRYLRGFFTQRRFRSLRQ 1916

  Fly  1039 KVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDV-----------AASKIQKAFRGFRDRVRL 1092
            |:|.:||..|..|||:|.:..:...|..:...|..|           ...:.|:|:...::.:..
  Rat  1917 KIILLQSRARGFLARQRYQQMRQSLLKFRSLVHTYVNRRRYLKLRAERRRRAQEAWLREQEELSK 1981

  Fly  1093 PPLVNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLN 1157
            ..:|..:..::....|..::. |...:..|:.||.: .||.|.|....::..:.|.|..|
  Rat  1982 REVVPVRHLEVPAEVAGLLQA-AAGLKPSSVPQVAI-VRAPRLQAEPCVTLPLDINNYPM----- 2039

  Fly  1158 KCTRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVD-PANSISRQAFPNQLLT 1221
                 ..|.|.:.:|   ...|.|.||: |||.         ||.:|: .|.:||  .|  :|:.
  Rat  2040 -----AKFIRCHFKE---PSFGMLTVPL-KMPL---------TQMLVEHHAEAIS--VF--KLIL 2082

  Fly  1222 QHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGY----FRDP--QQ 1280
            :.|.|.                    :.:..::....|:        |.:||.    .||.  .|
  Rat  2083 RFMGDP--------------------HLHGTQEMILGNY--------IVHQGLVEPALRDEILAQ 2119

  Fly  1281 LRRNQMQMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNY------ 1339
            | .||:..|.||||          ..:.|.:..:     .|.|:|         |||:.
  Rat  2120 L-ANQVWRNPNAYN----------AKRGWLLLAA-----CLSGFA---------PSSHLDKFLLK 2159

  Fly  1340 ----YRNNPNQ---QQRNYQQRSS-----YPPSD----PVRELQNMARN----EGDNSEDP 1380
                |..|..|   |.|..|...|     :||:.    .::|..:||.:    .||....|
  Rat  2160 FVSDYGQNGFQAVCQHRLLQAMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCP 2220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	203/751 (27%)
Myo15a	NP_001414755.1	None