DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and Myo7b

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_001178870.1	Gene:	Myo7b / 498834	RGDID:	1561153	Length:	2152	Species:	Rattus norvegicus

Alignment Length:	1065	Identity:	249/1065 - (23%)
Similarity:	450/1065 - (42%)	Gaps:	156/1065 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 MYP------EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYR 390
            |:|      :|:..|.:..:..::.:|..|....:.|::.|.||:::|..::...:..|....|.
  Rat    59 MHPNSAQGVDDMIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYY 123

  Fly   391 FKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGR 455
            .:...|..||:|::|:..|.:|..:|..|..::||||.:||:...:|:::.|..:...:.....:
  Rat   124 SRHMGELPPHVFAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSGQHSWIEQQ 188

  Fly   456 VESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFH 520
            |..:...:....||.|..|::|:|......:.|..:|.:.||....::|||.||......:.|:|
  Rat   189 VLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYH 253

  Fly   521 IFYYFY--DFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRD 583
            |||...  ..:.::|.|   .|.....|.||.:........|...:|        |....:.::.
  Rat   254 IFYCMLMGMSLEEKNML---GLGMPSEYHYLTMGNCTSYEGLSDAKD--------YAHVRSAMKI 307

  Fly   584 IDFNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIA-----ELLRVDEKKFMWSLT 643
            :.|:..:...:.|:|||||::||:.| ....:..::::|::...|     :||.|..:.....|.
  Rat   308 LQFSDSENWDISKLLAAILHLGNVGF-MAAVFENLDSSDVMETPAFPFAMKLLEVQHQALRDCLI 371

  Fly   644 NFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDT--NAIIIH 706
            ...:...|....|.....:|.|.|||....:|..|..:|:.:||..:..|:|.....  .||.:.
  Rat   372 KHTIPILGEFVSRPLNIAQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPQAQDPQNVRRAIGLL 436

  Fly   707 DMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLT 771
            |:||||.|..|..|||.||..||.:|..:.:.:|..|..|..:|:|....:::.||:..||.|..
  Rat   437 DIFGFENFQNNSFEQLCINFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLAL 501

  Fly   772 KPDGLFYIIDDASRSCQDQDLIM----DRVSEKHSQFVKKHTA--TEISVAHYTGRIIYDTRAFT 830
            ||..:..::|:.||..|..|:.|    :.:...:..|::..:.  |...:||:.|.:.|....|.
  Rat   502 KPMSIISLLDEESRFPQGTDVTMLQKLNSIHANNKSFLRPKSIHDTRFGIAHFAGDVYYQAEGFL 566

  Fly   831 DINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCI 895
            :.|||.:..:::....||.::.:..:|        ||.:|...:.|....:.|     |.:.|.|
  Rat   567 EKNRDVLSTDILILIHSSKNKFLKEIF--------NLDLPQTKLGHGTICQVK-----TKTGGQI 618

  Fly   896 SQVNNLR----TLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKAL 956
            .:.::..    ||::.|:.:...|:|:|:   |...:|||||:.:...||..|..::..||::..
  Rat   619 FKPSDSTKRSVTLSSQFKQSLEQLMKILT---NCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYS 680

  Fly   957 GVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDN------CRLLFLRLKME-GWAL 1014
            |:::||..|:.||..|..||||.:|::.|   ...|..:...|      .|:..|.|..: .|.:
  Rat   681 GMMETVHIRKSGFPIRYTFDEFSQRFRVL---LPSPERVQFQNKHRQMTSRIADLCLGTDKEWKM 742

  Fly  1015 GKTKVFLRYYNDEFLARLYELQ-----------VKKVIKVQSMMRALLARKRV--------KG-- 1058
            ||||:||:.:.|..|    |:|           :::|::.....:..|.:||.        :|
  Rat   743 GKTKIFLKDHQDTML----EIQRSQALDGAAIRIQRVLRGHKYRKEFLRQKRAAVTLQAVWRGHN 803

  Fly  1059 -GKVFKLGKKGPEHHDVAASK--IQKAFRGFRDRV-----RLPPLVNEKSGQLNENTADFIRPFA 1115
             .|.|||...|.|.....|..  :.:.|:..|.::     |....:..:..|........|:..|
  Rat   804 QRKNFKLILMGFERLQAIARSHLLMRQFQTMRQKIVQLQARCRGYLVRQQVQAKRRAVVIIQAHA 868

  Fly  1116 K-------KWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERI--NMR 1171
            :       .|::||....::..:..:.|......::..||        :..|.....|::  .:.
  Rat   869 RGMVARKSYWQQKSSGPPVILAKEPKGQGVALDRKRKSIY--------DTVTDTAMVEKVFGFLP 925

  Fly  1172 EVNSSQLGPLPVPIKKMPFR--------LDQIPFYDTQYMVDPANSISRQAFPNQLLT------Q 1222
            .:...|.||.|...:.:..:        ||.:|.  |:...:..:.::...||...:|      .
  Rat   926 AMIGGQEGPAPTRFEDLEVKTQKLHEVDLDTVPM--TEMPGEDVDGLAEYTFPKFAVTYFQKSAS 988

  Fly  1223 HMEDDEPWDSPL--QRNPSMTSCALTY--------------NAYKKEQACQTN-----WDRMGES 1266
            |....:|...||  ..|.:..|.||..              .||.:.....::     .||: :.
  Rat   989 HTHIQKPLRYPLLYHENDTDHSAALAVWIIILRFMGDLPEPQAYGRSSLTGSSVMRQIHDRL-DK 1052

  Fly  1267 DNIYNQGYFRDPQQLRRNQMQMNMN 1291
            |:: .||    ||..|..|:....|
  Rat  1053 DSV-TQG----PQHNRSTQVASQQN 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		S_TKc	16..282	CDD:214567
		MYSc	327..1034	CDD:214580	190/733 (26%)
		MYSc_Myo21	346..1022	CDD:276848	183/701 (26%)
Myo7b	NP_001178870.1	MYSc	60..761	CDD:214580	190/735 (26%)
		MYSc_Myo7	79..750	CDD:276832	183/701 (26%)
		IQ	787..809	CDD:197470	4/21 (19%)
		MyTH4	991..1194	CDD:214535	19/88 (22%)
		B41	1201..1414	CDD:214604
		FERM_B-lobe	1304..1405	CDD:271216
		FERM_C1_MyoVII	1408..1504	CDD:270019
		SH3	1505..1565	CDD:302595
		MyTH4	1646..1793	CDD:214535
		B41	1802..2014	CDD:214604
		FERM_M	1912..2014	CDD:278785
		FERM_C2_MyoVII	2010..2105	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810