Protein Alignment ninaC and Myo3a

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001406660.1
• Gene: Myo3a / 498806
• RGDID: 1560083
• Length: 1614
• Species: Rattus norvegicus
• Alignment Length: 1507
• Identity: 456/1507 - (30%)
• Similarity: 710/1507 - (47%)
• Gaps: 235/1507 - (15%)

  Fly     6 YAQLPDPTDKFEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQV--SIEEEYRTLRDYC 68
            :...|||:|.:||.|.|.:|...|||:.....|.:..|:||  .|..|.:  .||.||..||...
  Rat    11 FDNFPDPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILRTLS 73

  Fly    69 DHPNLPEFYGVY-KLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRA 132
            ||||:..|||:| |..|.|| |::|.|:|.|.||:..|:|...||...||.|..||||:.|....
  Rat    74 DHPNVVRFYGIYFKKDKING-DKLWLVLELCNGGSVTDLVKGFLKRGERMSEPIIAYILHEALMG 137

  Fly   133 AIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSAMES 197
            ...|:.|..:|||::|:|||||..|.|||.|||:|.|:.||..:..|.:|:|.||||||::..:.
  Rat   138 LQHLHSNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIACEQQ 202

  Fly   198 REPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISES 262
            .:.....|.|.|:||||.|||.||.||.|::||.||:|:|.|||||.|.:|..||.:.|||||:.
  Rat   203 LDTTYDARCDTWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKC 267

  Fly   263 LEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYK--EPELFVDRGYVKRF 325
            |.|:.|.||.:.::::|.|:|::...:..::..:.|.:::.:.:.:..|  ...:...:|.:.|.
  Rat   268 LTKDYEKRPTVSDLLKHKFITQIEGRDAILQKQLMEFIDIHQCLGSTEKARHERIHTKKGNLNRS 332

  Fly   326 DEKPEKMYPEDLAALENPVDENII-ESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKY 389
            .....|.. :|||.|: .:|||.: |.|.......:.|.::||||::||..:....:..:....|
  Rat   333 LISSLKDV-DDLATLD-VLDENTVSEHLEKCYSRDQIYIYVGDILIALNPFQSLGLYSTKLSKLY 395

  Fly   390 RFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATG 454
            ....|:.|.||||:|||:.||.|:.:...|.||:||||.:||:.:|.||::||..||..|...
  Rat   396 IGAKRTANPPHIFAVADLGYQSMVTYNADQCIVISGESGAGKTESAHLLVQHLTVLGKANNRT-- 458

  Fly   455 RVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGT 515
             ::..|..:..||    ||.|.:|::|:|......:.|..:|.:.||..:.|:|||.||......
  Rat   459 -LQEKILQMNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIG 522

  Fly   516 QHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVE-------- 572
            :.|||||||.|..:.::.:|..|.|           |...||   :|.::|....|:
  Rat   523 EKNFHIFYYIYAGLAEKKKLALYKL-----------PENKPP---RYLQNDNLRTVQDMMNNSFY 573

  Fly   573 --RYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVE-----NTDIVSRIAEL 630
              :|...|...:.|.|..:||.:|..|||||||:|||.|.......:::     |...:...|.|
  Rat   574 KSQYELIEQCFKVIGFTMEQLGSVYSVLAAILNVGNIEFSSVATEYQMDKSYICNHTALENSASL 638

  Fly   631 LRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRA 695
            |.:...:...:||:..:|..|....|..|.|:|.|.|||.|.|||.||..:|:|.||..:....:
  Rat   639 LCIQADELQEALTSHCVVTRGETIIRPNTVEKATDVRDATAKTLYGRLFSWIVNCINSLLKHDTS 703

  Fly   696 VFGDTNAII-IHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNF 759
            ..|:....| |.|:||||.|.:|..|||.||..|||:||::||.:|..|..|...||:|...:.:
  Rat   704 PSGNEELNIGILDIFGFENFKKNSFEQLCINIANEQIQYYFNQHVFAWEQNEYLNEDVDARVIEY 768

  Fly   760 YDNKTALDNLLTKPDGLFYIIDDASR--SCQDQDLIMDRVSEKHSQFVKKHTATEIS--VAHYTG 820
            .||:..||..|.||.||.:::|:.||  ...||.|:........||:..:....|:|  :.||.|
  Rat   769 EDNRPLLDMFLQKPMGLLFLLDEESRFPKATDQTLVEKFEDNLKSQYFWRPKRMELSFGIHHYAG 833

  Fly   821 RIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTM--PFEAVQHKDESERK 883
            :::|....|...|||.:|.:::...|||.:..|..:..:.|||.|||.:  ....|.::.::..|
  Rat   834 KVLYSASGFLAKNRDTLPTDIVLLLRSSENSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMQNSEK 898

  Fly   884 SYALNTLSAGCIS----QVNNLR--TLAANFRFTCLTLL-KMLSQNANLGVHFVRCIRADLEYKP 941
            |..||......::    :..|::  |:::.||::.:.|| ||:....    ||||||:.:.:.:.
  Rat   899 STNLNKSETRDVTRHAYETTNVKTQTVSSYFRYSLMDLLSKMVVGQP----HFVRCIKPNNDRQA 959

  Fly   942 RSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLR 1006
            |.:..:.|..|::..|:|:|...|:.|:|.|:.|..|::||..|.:...|...::.|.|..:..:
  Rat   960 RKYDKEKVLIQLRCTGILETARIRRLGYSHRILFANFIKRYYVLCYKSSEEPPVSPDTCATILEK 1024

  Fly  1007 LKMEGWALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEH 1071
            ..::.||||||||||:||:.|.|..:.:..:.|::.:|:.:||.|..||.:     :|.:|
  Rat  1025 AGLDNWALGKTKVFLKYYHVEQLNLMRKEAIDKLVLIQASVRAFLGAKRYQ-----ELQQK---- 1080

  Fly  1072 HDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNEN---TADF-IRPFAKKWREKSIFQVLLHYRA 1132
            ...:|..||.|.|  |..:|       |.|:...|   ||.. :|...:::..|..|:
  Rat  1081 RKTSAVIIQSAAR--RHLLR-------KQGKKTSNVQSTAGMSVRAKDQEFDYKKNFE------- 1129

  Fly  1133 ARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERINMREVNSSQLGPLPVPIKKMPFRLDQIPF 1197
            .:.:.||    :.|..|            |||....|:...|:.:   .|...|..|||.:
  Rat  1130 TKRESFV----KKHTEN------------AVPTNESNIPTPNNKE---SPSAGKTAPFRAE---- 1171

  Fly  1198 YDTQYMVDPANSISRQAFPNQLLTQHMEDDEPWDSPLQRNPSMTSCALTYNAYKKEQACQTNWDR 1262
                                                 .:..::.|....|...||    .:|...
  Rat  1172 -------------------------------------AKATNVESNNRKYQTQKK----MSNVYA 1195

  Fly  1263 MGESDNIY-----------NQGYFRDPQQLRRNQMQMNMNAYNNAYNSY---NSNYNNQNWGVHR 1313
            .|::..:|           .|.|.:|.::.|:.:.:...:|...:|..:   .||:..
  Rat  1196 EGQNQELYIVGDSWVEVSPRQKYVQDLEESRKLRKEEKGDAVIQSYCQWYTEGSNFEE------- 1253

  Fly  1314 SGSRRNSLKGYAAPPPP-----------------PPPMPSSNYYRN-NPNQQQR----------- 1349
              |:...|:|.|....|                 .|.:...:.|:| |.|::::
  Rat  1254 --SKATCLEGKATWEKPSCPGLWLTEEIYLRKTLDPSLSQKSVYQNANSNEKEKKTSVVTQSAPL 1316

  Fly  1350 ----------NYQQRSSYPPSDPVRE-------LQNMARNE------GDNSEDPPF-NFKAMLRK 1390
                      .:.......|.|..:|       :|:..||.      |.::..||| |.|.:...
  Rat  1317 GNLGKDYHLHGFLGEKDTGPVDQAQEEDKAAVFIQSKYRNSKQKQQLGKDNLSPPFKNEKILSSP 1381

  Fly  1391 TNYPRGSETNTY 1402
            |...|.:. |.|
  Rat  1382 TEVARNTR-NVY 1392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	127/275 (46%)
		MYSc_Myo21	346..1022	CDD:276848	233/709 (33%)
Myo3a	NP_001406660.1	Protein Kinases, catalytic domain	2..287	CDD:473864	127/278 (46%)
		MYSc_Myo3	352..1040	CDD:276830	232/708 (33%)
		MBD_Myo3a	1408..1455	CDD:439318