DRSC/TRiP Functional Genomics Resources

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Protein Alignment ninaC and MYO10

DIOPT Version :10

Sequence 1:NP_523503.2 Gene:ninaC / 34012 FlyBaseID:FBgn0002938 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_036466.2 Gene:MYO10 / 4651 HGNCID:7593 Length:2058 Species:Homo sapiens


Alignment Length:1311 Identity:319/1311 - (24%)
Similarity:543/1311 - (41%) Gaps:253/1311 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   255 INDFISES----LEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPEL 315
            :::|.:|.    |.:|.::.|..|.......:.        .|:|..::.        .||:..:
Human     1 MDNFFTEGTRVWLRENGQHFPSTVNSCAEGIVV--------FRTDYGQVF--------TYKQSTI 49

  Fly   316 FVDRGYVKRFDEKPEKMYP------EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNS 374
                     ..:|...|:|      :|:|:|......:|:.:|..|....:.|::||.||.|:|.
Human    50 ---------THQKVTAMHPTNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNP 105

  Fly   375 NE-IKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLL 438
            .: |...:......:|..:...|..||||::|:..|:.:....:.|.|::||||.:||:.:.:|:
Human   106 YQPIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLI 170

  Fly   439 IKHLCYLGDGN-----RGATGRVESSIKAILMLV----NAGTPVNNDSTRCVLQYCLTFGK---- 490
            :|.|..:...:     :..|..||.:|.....::    ||.|..||:|:|        |||    
Human   171 LKFLSVISQQSLELSLKEKTSCVERAILESSPIMEAFGNAKTVYNNNSSR--------FGKFVQL 227

  Fly   491 ----TGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRV 551
                .|.:.|.....|:|||.||...:..:.|:||||.....:..:.: :|:.|....||.||..
Human   228 NICQKGNIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEER-EEFYLSTPENYHYLNQ 291

  Fly   552 PPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFRQNGKYA 616
            ...|        .|....:.|.:||....:..:.|:.:::..|.::||.||::|||.|...|. |
Human   292 SGCV--------EDKTISDQESFREVITAMDVMQFSKEEVREVSRLLAGILHLGNIEFITAGG-A 347

  Fly   617 EVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDF 681
            :|.....:.|.||||.:|..:...:||...|...|.........::|.|:||::|..||:...::
Human   348 QVSFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEEILTPLNVQQAVDSRDSLAMALYACCFEW 412

  Fly   682 IINRINMNMSFPRAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLE 746
            :|.:||..:....    |..:|.|.|:||||.|..|..||..||..||::|.::|:.||..|.||
Human   413 VIKKINSRIKGNE----DFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLE 473

  Fly   747 MEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQD-LIMDRVSEKHSQ---FVKK 807
            ...|.:...::::.||...|| |:.|..||..:|::.|...|..| .:::::..:|:.   :||.
Human   474 YSREGLVWEDIDWIDNGECLD-LIEKKLGLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKP 537

  Fly   808 HTA-TEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPF 871
            ..| ....|.||.|.:.||.|...:.|||        |||   |:.:.|:..::.....:|   |
Human   538 RVAVNNFGVKHYAGEVQYDVRGILEKNRD--------TFR---DDLLNLLRESRFDFIYDL---F 588

  Fly   872 EAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRAD 936
            |.|..::..:       ||..|   ..:...|:::.|:.:..:|:..||.:   ...|||||:.:
Human   589 EHVSSRNNQD-------TLKCG---SKHRRPTVSSQFKDSLHSLMATLSSS---NPFFVRCIKPN 640

  Fly   937 LEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCR 1001
            ::..|..|...||..|::..|:|:||..|:.|::.|.||.:|.:||:.|..:...| |..:..|.
Human   641 MQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALP-EDVRGKCT 704

  Fly  1002 LLFLRL---KMEGWALGKTKVFLRYYNDE-----------------------FLAR-LYELQVKK 1039
            .| |:|   ....|.|||||||||...::                       |||| .|...:..
Human   705 SL-LQLYDASNSEWQLGKTKVFLRESLEQKLEKRREEEVSHAAMVIRAHVLGFLARKQYRKVLYC 768

  Fly  1040 VIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLN 1104
            |:.:|...||.|.|:|..             |...||...||..||...|.....|:.||..|..
Human   769 VVIIQKNYRAFLLRRRFL-------------HLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEE 820

  Fly  1105 ENTADFIRPFAKKWREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVPFERIN 1169
            :...:   ...||.||:...:.....|.|.    :...|:.....|:.:..|.|..:.....|..
Human   821 KKKQE---EEEKKKREEEERERERERREAE----LRAQQEEETRKQQELEALQKSQKEAELTREL 878

  Fly  1170 MREVNSSQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLTQHMEDDEPWDSPL 1234
            .::..:.|:..:        .||:: ...|.|.|.:.......:|...:|  |...|.|     |
Human   879 EKQKENKQVEEI--------LRLEK-EIEDLQRMKEQQELSLTEASLQKL--QERRDQE-----L 927

  Fly  1235 QRNPSMTSCALTYNAYKKEQACQT--------NWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMN 1291
            :|              .:|:||:.        |:|.:.|.              :|..:..:::.
Human   928 RR--------------LEEEACRAAQEFLESLNFDEIDEC--------------VRNIERSLSVG 964

  Fly  1292 AYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRNY-QQRS 1355
            :..::..:.::.....|:...:........:|:.|         ..:.::::||..:..: .||:
Human   965 SEFSSELAESACEEKPNFNFSQPYPEEEVDEGFEA---------DDDAFKDSPNPSEHGHSDQRT 1020

  Fly  1356 SYPPSDPVRELQNMARNEGDNSEDPPFNFKAMLRKTNYPRGSET-----NTYDFNNRRGSDSGDQ 1415
            |            ..|...|:||:.|:....::..:  |....|     :..|..:...|.||:.
Human  1021 S------------GIRTSDDSSEEDPYMNDTVVPTS--PSADSTVLLAPSVQDSGSLHNSSSGES 1071

  Fly  1416 HTFQPPK----LRSTGRRY---QDD--EGYNSSSGNYGVSRKFGQQQRAPTLRQSPASVGRSFED 1471
             |:..|:    |.|....|   |||  :|..:|..:...|..:|.|. :|..|   .||| ::..
Human  1072 -TYCMPQNAGDLPSPDGDYDYDQDDYEDGAITSGSSVTFSNSYGSQW-SPDYR---CSVG-TYNS 1130

  Fly  1472 SNARSFEEAGS 1482
            |.|..|...|:
Human  1131 SGAYRFSSEGA 1141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ninaCNP_523503.2 STKc_myosinIII_N_like 9..282 CDD:270785 6/30 (20%)
MYSc_Myo21 346..1022 CDD:276848 205/701 (29%)
MYO10NP_036466.2 SH3_19 7..58 CDD:465815 10/75 (13%)
MYSc_Myo10 77..727 CDD:276840 205/701 (29%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 8/24 (33%)
SMC_N 727..>958 CDD:481474 56/294 (19%)
SAH. /evidence=ECO:0000269|PubMed:23012428 814..883 14/75 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..840 4/23 (17%)
PTZ00108 <846..1161 CDD:240271 67/373 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..866 2/22 (9%)
DUF5401 <848..967 CDD:375164 25/162 (15%)
MYO10_CC 883..933 CDD:465249 13/79 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1090 23/149 (15%)
PH-like 1181..>1223 CDD:473070
PH2_MyoX 1215..1316 CDD:270108
PH3_MyoX-like 1381..1506 CDD:270109
MyTH4 1549..1695 CDD:214535
FERM_F1_Myosin-X 1697..1792 CDD:340726
B41 1704..1958 CDD:214604
FERM_C_MyoX 1954..2042 CDD:270023
Blue background indicates that the domain is not in the aligned region.

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