DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaC and MYO9B

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	NP_004136.2	Gene:	MYO9B / 4650	HGNCID:	7609	Length:	2157	Species:	Homo sapiens

Alignment Length:	1449	Identity:	324/1449 - (22%)
Similarity:	542/1449 - (37%)	Gaps:	430/1449 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 VDRGYVKR----FDEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEI 377
            |:||.:.|    ||         ||..|....:.|::::|:||.|..:.|::.|.||:::|..:.
Human   136 VERGLLPRQQADFD---------DLCNLPELTEGNLLKNLKHRFLQQKIYTYAGSILVAINPFKF 191

  Fly   378 KQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHL 442
            ...:..::...|..:...:.:||:|::||:||..||..:..|.||:||||.|||:.:...||.
Human   192 LPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIH-- 254

  Fly   443 CYLGDGNRGATGRVESSI----KAILMLVNAGTPVNNDSTRCVLQYCLTFGK--------TGKMS 495
            |......:|....||.:|    ..:....||.|..||:|:|        |||        :|.:.
Human   255 CLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSR--------FGKFIQVSYLESGIVR 311

  Fly   496 GAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKL 560
            |||...|:|||.|:.:.:..:.|:|:|||....::::.: :|:.||...:|.||.      ...|
Human   312 GAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEER-QEFQLKQPEDYFYLN------QHNL 369

  Fly   561 KYR-RDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRF------RQNGKYAEV 618
            |.. .:|.:.:.||.::...::..:....||   :..||:|||.:||:.:      |:.|  .||
Human   370 KIEDGEDLKHDFERLKQAMEMVGFLPATKKQ---IFAVLSAILYLGNVTYKKRATGREEG--LEV 429

  Fly   619 ENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYSRLVDFII 683
            ...:::..:::||:|..:..:..||....|.........|:..||..|||::|.:|||.|.|:|:
Human   430 GPPEVLDTLSQLLKVKREILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIV 494

  Fly   684 NRINMNMSFPRAVFGDTNAIIIH--DMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLE 746
            .|||..:...:.|....:.:.|.  |:||||.|.||..||..||..|||:||::||.||..|..|
Human   495 LRINHALLNKKDVEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFNQHIFKLEQEE 559

  Fly   747 MEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASR--SCQDQDLIMDRVSEKHSQFVKKHT 809
            .:.|.|...|:.:.||...:..:..||.||||::|:.|.  ....|.|:        ::|.::|.
Human   560 YQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLL--------AKFKQQHE 616

  Fly   810 ATE-----------ISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSS--------------- 848
            ..:           ..:.|:.|::.|..:.|.:.|.|::.|:::...|.|
Human   617 DNKYFLGTPVMEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVA 681

  Fly   849 ------LDESIMLMF---------TNQLTKAGNLTMPFEAVQHKDESER---------------- 882
                  |..:|..|.         ..:..||..::.| .|..|.:|..|
Human   682 VFRWAVLRAAIRAMAVLREAGRLRAERAEKAAGMSSP-GAQSHPEELPRGASTPSEKLYRDLHNQ 745

  Fly   883 --------------------------KSYALNTLSAG-------------------CISQVNNLR 902
                                      |..|....|.|                   .||...:.|
Human   746 MIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLDSKSLKLIISMTLHDR 810

  Fly   903 T---------------LAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQ 952
            |               ::|.|:   .:|.|:|.........|:||||::.|.|...|..::|.||
Human   811 TTKSLLHLHKKKKPPSISAQFQ---TSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQ 872

  Fly   953 MKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKD--NCR----LLFLRLKME- 1010
            ::..|:|:||..|:.|:|::..|.:|..::|.|         :.||  .||    .|..::|::
Human   873 LRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVL---------LPKDAQPCREVISTLLEKMKIDK 928

  Fly  1011 -GWALGKTKVFLRYYNDEFLAR-LYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHD 1073
             .:.:|||||||:....:.|.. |:...|:|::.:||..|.:|.|:.      |...|:
Human   929 RNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRH------FLQMKR------ 981

  Fly  1074 VAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWR-----------EKSIFQVL 1127
             ||..||..:|.:|.|..|     |::     ..|.:::   ..||           ::||.::.
Human   982 -AAVTIQACWRSYRVRRAL-----ERT-----QAAVYLQ---ASWRGYWQRKLYRHQKQSIIRLQ 1032

  Fly  1128 L----HYRAARFQDFVNLSQQVHIY---------------NQRMVAGLNKCTRAVP------FER 1167
            .    |.:...|...::..|:....               .|...||..:.....|      ...
Human  1033 SLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGPEPAEDGGHL 1097

  Fly  1168 INMREVNSSQLGPL---------PVPIKKMPFRLDQIPFYDTQYMVDPANSI---SRQAFPNQLL 1220
            .:..||..|...||         |.|.|.:|                |..::   |.:..|:
Human  1098 ASEPEVQPSDRSPLEHSSPEKEAPSPEKTLP----------------PQKTVAAESHEKVPS--- 1143

  Fly  1221 TQHMEDDEPWDSPLQR--------NPSMTSCALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRD 1277
                 ..|..:|..||        |..:.||       |:|.|.:....|:.:...:   ....|
Human  1144 -----SREKRESRRQRGLEHVKFQNKHIQSC-------KEESALREPSRRVTQEQGV---SLLED 1193

  Fly  1278 PQQLRRNQ--MQMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAP------------- 1327
            .::.|.::  :.:...|.|.:.............|.....:.:....|...|
Human  1194 KKESREDETLLVVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDS 1258

  Fly  1328 ---PPPPPPMPSSNYYRNNP----------------NQQQR------------------------ 1349
               ||.|...|.:...::.|                .|.||
Human  1259 RVSPPAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAAS 1323

  Fly  1350 ------------------------NYQQRSSYPPSDPVRELQNMAR-------NEGDNSEDPPFN 1383
                                    ..::|:|:..||..:.|.::|:       .:|:.|...|
Human  1324 PSAMLSQSLDLSDRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKP-- 1386

  Fly  1384 FKAMLRKTNYPRGSETNTYDFNNRRGSDSGDQHTFQPPKLRSTGRRYQDDEG----YNSSSGNY- 1443
              |:.:|   ..|..::..|.....||....:.||:...|..|..:....||    .|:.||:.
Human  1387 --AVQKK---KPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELENAVSGHVV 1446

  Fly  1444 --------GVSRKFGQQQR 1454
                    |:....|||.|
Human  1447 LEATTMKKGLEAPSGQQHR 1465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		S_TKc	16..282	CDD:214567
		MYSc	327..1034	CDD:214580	221/855 (26%)
		MYSc_Myo21	346..1022	CDD:276848	215/823 (26%)
MYO9B	NP_004136.2	Myosin_IXb_RA	7..112	CDD:176374
		MYSc	141..950	CDD:214580	223/860 (26%)
		MYSc_Myo9	160..941	CDD:276836	215/823 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..734		7/25 (28%)
		Actin-binding. /evidence=ECO:0000305	844..855		4/10 (40%)
		Neck or regulatory domain. /evidence=ECO:0000305	940..1044		27/129 (21%)
		IQ	978..999	CDD:197470	8/27 (30%)
		IQ	1000..1022	CDD:197470	4/29 (14%)
		Tail. /evidence=ECO:0000305	1045..2157		72/462 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1298		41/285 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1410		15/96 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1484		5/11 (45%)
		C1	1633..1681	CDD:237996
		RhoGAP_myosin_IXB	1698..1883	CDD:239872
		Interaction with RHOA. /evidence=ECO:0000269\|PubMed:26529257	1739..1744
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1980..2157
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810