Protein Alignment ninaC and MYO9A

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_011519915.1
• Gene: MYO9A / 4649
• HGNCID: 7608
• Length: 2638
• Species: Homo sapiens
• Alignment Length: 1048
• Identity: 253/1048 - (24%)
• Similarity: 445/1048 - (42%)
• Gaps: 248/1048 - (23%)

  Fly   311 KEPELFVDRGYVKRFDEKPEKMYPEDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSN 375
            :|....::||::    .:|::...:||.:|.:..::.::|:||:|....:.|:::|.||:.:|..
Human   129 EERRRMMERGFL----PQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPF 189

  Fly   376 EIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIK 440
            :....:..::...|......:.:|||::|||:||..||..|:.|.||:||||.|||:.:...||.
Human   190 KFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIH 254

  Fly   441 HLCYLGDGNRGATGRVESSI----KAILMLVNAGTPVNNDSTRCVLQYCLTFGK--------TGK 493
            ||..|  ..:|....||..|    ..:....||.|..||:|:|        |||        ||.
Human   255 HLTAL--SQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSR--------FGKFIQVNYQETGT 309

  Fly   494 MSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPS 558
            :.||....|:|||.|:...:..:.|:|:|||.....: :::...::||....|.||.   ::...
Human   310 VLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGAS-EDERSAFHLKQPEEYHYLN---QITKK 370

  Fly   559 KLKYRRDD-----------PEGNVERYREFENI---LRDIDFNHKQLETVRKVLAAILNIGNIRF 609
            .|:...||           .||...|: :||.:   :..:.|..|....:..:|:|||::|||.:
Human   371 PLRQSWDDYCYDSEPDCFTVEGEDLRH-DFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICY 434

  Fly   610 RQ---NGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVA 671
            ::   .....::.|.:::..::|||.|.|:....:|.....|..|......|...||...|:::|
Human   435 KKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMA 499

  Fly   672 STLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIH--DMFGFECFNRNGLEQLMINTLNEQMQYH 734
            .:|||.|.|:|:.|||..:...:.:..:|..:.|.  |:||||.:..|..||..||..||::|::
Human   500 KSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHY 564

  Fly   735 YNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQ-DQDLIMDRVS 798
            :||.||..|..|...|.|...|:::.||...::.:..||.||.:::|:.|...| ....::|:..
Human   565 FNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFK 629

  Fly   799 EKH--SQFVKKHTATE--ISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESI------ 853
            .:|  :.:::.....|  ..:.||.|::.|..:.|.:.|.|.:.|:::...|||.:..|
Human   630 HQHEDNSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGI 694

  Fly   854 -----------------MLMF-----TNQLTKAG-NLTMP---------FEAVQH---------- 876
                             |:.|     .|...|.| :.|.|         |..:||
Human   695 DPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEIL 759

  Fly   877 ---KDES---ERKS-----------YALN---------------------TLSAGC--------- 894
               |:|.   .||:           .|||                     .||:|.
Human   760 QRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIF 824

  Fly   895 -------------------------------ISQVNNLR-------------------------T 903
                                           :.:||:|:                         :
Human   825 ANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPS 889

  Fly   904 LAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKG 968
            ::|.|:.:...|::.|.|   ...:||:|||::.|..|..|...:|.:|::..|:|:||..||.|
Human   890 ISAQFQASLSKLMETLGQ---AEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSG 951

  Fly   969 FSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLF--LRLKMEGWALGKTKVFLRYYNDEFLAR 1031
            :||:..|.:|:..:..|   ....:..:|.|.:..|  :.|..:.:.:|||.|||:....:.|..
Human   952 YSSKYSFQDFVSHFHVL---LPRNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQD 1013

  Fly  1032 LYELQV-KKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPL 1095
            |...:| :::|.:|...|.||.|:...             |...|:..||:.:|.:.::.::...
Human  1014 LLHQEVLRRIILLQRWFRVLLCRQHFL-------------HLRQASVIIQRFWRNYLNQKQVRDA 1065

  Fly  1096 VNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYRAA------RFQDFVNLSQQVHIYNQRMVA 1154
            ..:|...:..:.|..::   ..||.....|..|..|||      :::|:         |.:|.:|
Human  1066 AVQKDAFVMASAAALLQ---ASWRAHLERQRYLELRAAAIVIQQKWRDY---------YRRRHMA 1118

  Fly  1155 GLNKCTRA 1162
            .:  |.:|
Human  1119 AI--CIQA 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	216/864 (25%)
MYO9A	XP_011519915.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1004	CDD:276836	216/864 (25%)
		C1_Myosin-IXa	2067..2124	CDD:410433
		RhoGAP_myosin_IX	2133..2318	CDD:239842