Protein Alignment ninaC and MYO7B

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: XP_047300391.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2298
• Species: Homo sapiens
• Alignment Length: 1059
• Identity: 251/1059 - (23%)
• Similarity: 437/1059 - (41%)
• Gaps: 209/1059 - (19%)

  Fly   320 GYVKRFDEKPEKMYPEDLAALE-----------NPVDENIIESLRHRILMGE------------- 360
            |.:|  :.||.|:..||....|           :|:..|.::.:...|.:|:
Human    26 GIIK--EAKPGKVLVEDDEGKEHWIRAEDFGVLSPMHPNSVQGVDDMIRLGDLNEAGMVHNLLIR 88

  Fly   361 -----SYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKEPQH 420
                 .|::.|.||:::|..::...:..|....|..:...|..||:|::|:..|..|..:|..|.
Human    89 YQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFSMKRNKRDQC 153

  Fly   421 IVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLVNAGTPVNNDSTRCVLQYC 485
            .::||||.:||:...:|:::.|..:...:.....:|..:...:....||.|..|::|:|......
Human   154 CIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYID 218

  Fly   486 LTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYRYLR 550
            :.|..:|.:.||....::|||.||......:.|:||||.....::.::: :..:|.....|.||.
Human   219 IYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDK-QLLSLGTPSEYHYLT 282

  Fly   551 VPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHKQLETVRKVLAAILNIGNIRFR----Q 611
            :........|...:|        |....:.::.:.|:..:...|.|:|||||::||:.|.    :
Human   283 MGNCTSCEGLNDAKD--------YAHIRSAMKILQFSDSESWDVIKLLAAILHLGNVGFMASVFE 339

  Fly   612 NGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAVASTLYS 676
            |...::|..|.....:.:||.|..::....|....::..|....|.....:|.|.|||....:|.
Human   340 NLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQAADRRDAFVKGIYG 404

  Fly   677 RLVDFIINRINMNMSFPRAVFGDT--NAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRI 739
            .|..:|:.:||..:..|.|.....  .||.:.|:||||.|..|..|||.||..||.:|..:.|.:
Human   405 HLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCINFANEHLQQFFVQHV 469

  Fly   740 FISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIM----DRVSEK 800
            |..|..|..:|:|....:::.||:..||.|..||..:..::|:.||..|..||.|    :.|...
Human   470 FTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGTDLTMLQKLNSVHAN 534

  Fly   801 HSQFVKK---HTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQL- 861
            :..|::.   |.| ...:||:.|.:.|....|.:.|||.:..:::....||.::.:..:|..:|
Human   535 NKAFLQPKNIHDA-RFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSKNKFLREIFNLELA 598

  Fly   862 -TKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLR--TLAANFRFTCLTLLKMLSQNA 923
             ||.|:.|:            |::.|.|.|..   |..:|.|  ||.:.|:.:...|:|:|:
Human   599 ETKLGHGTI------------RQAKAGNHLFK---SADSNKRPSTLGSQFKQSLDQLMKILT--- 645

  Fly   924 NLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFD 988
            |...:|:|||:.:...||..|..::..:|::..|:::||..|:.||..|..|:||.:|:..|.
Human   646 NCQPYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLL-- 708

  Fly   989 FDEPVEMTKDNCRLLFLRLKMEG-------------------WALGKTKVFLRYYNDEFLARLYE 1034
               |..|          |::::|                   |..||||:|||.:.|..|    |
Human   709 ---PNAM----------RMQLQGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDTLL----E 756

  Fly  1035 LQVKKVIKVQSMMRALLARKRVKGG----KVFKLGKKGPEHHDVAASKIQKAFRGFRDR------ 1089
            :|..:|:.     ||.|:.::|..|    |.|...::       ||..:|..:||:.:|
Human   757 VQRSQVLD-----RAALSIQKVLRGYRYRKEFLRQRR-------AAVTLQAWWRGYCNRRNFKLI 809

  Fly  1090 ----------VRLPPL------VNEKSGQLNENTADFIRPFAKKWREKSIFQVLLHYR--AARFQ 1136
                      .|..||      :.:::.||......::.....:.:.:::..:..|.|  |||
Human   810 LVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRGYLVRQQVQAKRRAVVVIQAHARGMAAR-- 872

  Fly  1137 DFVNLSQQVHIYNQRMVAGL----------NKCTRAVP-------FERINMREVNSSQLGPLPVP 1184
                     ..:.||...|:          .|...|:|       ::.:...|:.....|.||..
Human   873 ---------RNFQQRKANGMQAPLVIPAEGQKSQGALPAKKRRSIYDTVTDTEMVEKVFGFLPAM 928

  Fly  1185 I-------------------KKMPFRLDQIPFYDTQYMVDPANSISRQAFPNQLLT------QHM 1224
            |                   |.:...||.:|.  .:...:..:.::...||...:|      .|.
Human   929 IGGQEGQASPHFEDLESKTQKLLEVDLDTVPM--AEEPEEDVDGLAEYTFPKFAVTYFQKSASHT 991

  Fly  1225 EDDEPWDSPLQRNPSMTSC 1243
            ....|...||..:...|.|
Human   992 HIRRPLRYPLLYHEDDTDC 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	188/729 (26%)
MYO7B	XP_047300391.1	MYSc_Myo7	79..748	CDD:276832	185/711 (26%)
		IQ	785..807	CDD:197470	6/28 (21%)
		MyTH4	992..1221	CDD:214535	5/19 (26%)
		FERM1_F1_Myosin-VII	1225..1323	CDD:340612
		FERM_C1_MyoVII	1467..1550	CDD:270019
		SH3	1551..1611	CDD:473055
		MyTH4	1692..1839	CDD:214535
		FERM2_F1_Myosin-VII	1846..1943	CDD:340613
		B41	1848..2060	CDD:214604
		FERM_C2_MyoVII	2056..>2131	CDD:270020