DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaC and MYO7A

DIOPT Version :9

Sequence 1:	NP_523503.2	Gene:	ninaC / 34012	FlyBaseID:	FBgn0002938	Length:	1501	Species:	Drosophila melanogaster
Sequence 2:	XP_011543348.2	Gene:	MYO7A / 4647	HGNCID:	7606	Length:	2258	Species:	Homo sapiens

Alignment Length:	976	Identity:	234/976 - (23%)
Similarity:	418/976 - (42%)	Gaps:	189/976 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 PPTLMRPTNWSQQINDFISESLEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDV 306
            |..:.:|..|:                    :|..:...|.|..:...|.:..|:....|....:
Human    10 PARIPQPGKWA--------------------LVRSLNQAFKTYAVLPGDHVWMDLRLGQEFDVPI 54

  Fly   307 KTLYKEPELFVDRGYVKRFDEKPEK-------------MYP------EDLAALENPVDENIIESL 352
            ..:.|    ..|.|.|:..|::..:             |:|      ||:..|.:..:..|:.:|
Human    55 GAVVK----LCDSGQVQVVDDEDNEHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNL 115

  Fly   353 RHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPHIFSVADIAYQDMLHHKE 417
            ..|......|::.|.||:::|..::...:..|...:|..|...|..||||::||..|.:|..:..
Human   116 LIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNSR 180

  Fly   418 PQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLVNAGTPVNNDSTRCVL 482
            .|..::||||.:||:.:.:|:::.|..:...:.....:|..:...:....||.|..|::|:|...
Human   181 DQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGK 245

  Fly   483 QYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEYNLKADRNYR 547
            ...:.|.|.|.:.||....|:|||.||......:.|:|:||...:.:: ::|.|:..|....:|.
Human   246 YIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVFYCMLEGMS-EDQKKKLGLGQASDYN 309

  Fly   548 YLRVPPEVPPSKLKYRRDDPEGNVERYREFENI---LRDIDFNHKQLETVRKVLAAILNIGNIRF 609
            ||.:...:          ..||.|:. :|:.||   ::.:.|...:...:.|:|||||::||:::
Human   310 YLAMGNCI----------TCEGRVDS-QEYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQY 363

  Fly   610 R----QNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAERRQYTTEEARDARDAV 670
            .    :|....||..:..::..|.||.|:....|..||:..::..|.......:.|:|.|.|||.
Human   364 EARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAF 428

  Fly   671 ASTLYSRLVDFIINRINMNMSFP--RAVFGDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQY 733
            ...:|.||..:|:::||..:..|  :.|.....:|.:.|:||||.|..|..|||.||..||.:|.
Human   429 VKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQ 493

  Fly   734 HYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIIDDASRSCQDQDLIM-DRV 797
            .:.:.:|..|..|.:.|.||.:::.|.||:.|||.:..||..:..:||:.|:..:..|..| .::
Human   494 FFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKL 558

  Fly   798 SEKH---SQFV--KKHTATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMF 857
            :.:|   :.::  |.:..|:..:.|:.|.:.|:|:.|.:.|||.:..::|:...||.::.|..:|
Human   559 NSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHSSRNKFIKQIF 623

  Fly   858 TNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQN 922
            ...:....             |:.::|                 .||::.|:.:...|::
Human   624 QADVAMGA-------------ETRKRS-----------------PTLSSQFKRSLELLMR----- 653

  Fly   923 ANLGV---HFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQF 984
             .||.   .|||||:.:...||..|...:..:|::..|:::|:..|:.|:..|..|.||:.||:.
Human   654 -TLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRV 717

  Fly   985 L------AFD----------FDEPVEMTKDNCRLLFLRLKMEGWALGKTKVFLRYYNDEFLARLY 1033
            |      |:.          ..|.|..|.|:            |.:||||:||:.::|    .|.
Human   718 LLPGVKPAYKQGDLRGTCQRMAEAVLGTHDD------------WQIGKTKIFLKDHHD----MLL 766

  Fly  1034 ELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPEHHDVAASKIQKAFRGFRDRVRLPPLVNE 1098
            |::..|.|..:.::                               :||..|||:||.....|
Human   767 EVERDKAITDRVIL-------------------------------LQKVIRGFKDRSNFLKL--- 797

  Fly  1099 KSGQLNENTADFIRPFAKKWR----EKSIFQVLLHY-RAARFQDFVNLSQQVHIYNQRMVAGLNK 1158
                  :|.|..|:   :.||    .|:...:.|.: |.........|.||..:..||::....:
Human   798 ------KNAATLIQ---RHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQAR 853

  Fly  1159 C 1159
            |
Human   854 C 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785	4/39 (10%)
		S_TKc	16..282	CDD:214567	4/39 (10%)
		MYSc	327..1034	CDD:214580	195/759 (26%)
		MYSc_Myo21	346..1022	CDD:276848	187/709 (26%)
MYO7A	XP_011543348.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810