DRSC/TRiP Functional Genomics Resources

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Protein Alignment ninaC and MYO6

DIOPT Version :10

Sequence 1:NP_523503.2 Gene:ninaC / 34012 FlyBaseID:FBgn0002938 Length:1501 Species:Drosophila melanogaster
Sequence 2:NP_001355794.1 Gene:MYO6 / 4646 HGNCID:7605 Length:1294 Species:Homo sapiens


Alignment Length:973 Identity:231/973 - (23%)
Similarity:404/973 - (41%) Gaps:200/973 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 LADGKPPFADMHPTRA--MFQIIRNPPPTL-MRPTNWSQQINDFISESLEKNAENRPMMVEMVEH 279
            :.||||.:|. |||..  |..|:...|.:| :.|.|  |:...|::                   
Human     1 MEDGKPVWAP-HPTDGFQMGNIVDIGPDSLTIEPLN--QKGKTFLA------------------- 43

  Fly   280 PFLTELIENEDEMRSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPEDLAALENPV 344
             .:.::...|::.:.|:.:...|                             ||..:...|.|  
Human    44 -LINQVFPAEEDSKKDVEDNCSL-----------------------------MYLNEATLLHN-- 76

  Fly   345 DENIIESLRHRILMGESYSFIGDILLSLNSN-EIKQEFPQEFHAKYRFKSRSENQPHIFSVADIA 408
                   ::.|......|:::.:||:::|.. :|.:.:..|....|:.||.....||:|::||.|
Human    77 -------IKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKA 134

  Fly   409 YQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAILMLVNAGTPV 473
            ::||...|..|.|::||||.:||:.|.:.::::|.......:....|:..:...:....||.|..
Human   135 FRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVR 199

  Fly   474 NNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYFYDFINQQNQLKEY 538
            ||:|:|......:.|.:...:.|...:.|:|||.|:......:.|:||||......::..: ::.
Human   200 NNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIR-EKL 263

  Fly   539 NLKADRNYRYL--------------------RVPPE-VPPSKLKYRRDDPEGNVERYREFENILR 582
            :|.:..|:|||                    |..|| :....:|....|..|:..|   ....::
Human   264 HLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIR---MCTAMK 325

  Fly   583 DIDFNHKQLETVRKVLAAILNIGNIRFRQNGKYA-----EVENTDIVSRIAELLRVDEKKFMWSL 642
            .|..:.::...:.:|:|.:|::|||.|.:.|..:     :.::...:...||||.:|:.....||
Human   326 KIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSL 390

  Fly   643 TNFIMV------KGGIAERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTN 701
            |..:|:      ||.:. :.....|:|.:||||:|.|:||.|.|.::||:|....|      :|:
Human   391 TTRVMLTTAGGTKGTVI-KVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPF------ETS 448

  Fly   702 AIIIH--DMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKT 764
            :..|.  |:.|||.|..|..||..||..||::|..:|:||...|....:.|.:....:::.||:.
Human   449 SYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQD 513

  Fly   765 ALDNLLTKPDGLFYIIDDASRSCQDQDL-IMDRVSEKHSQFVKKHTATEIS-------------- 814
            .:|.:..|..|:..|:|:.:|..|..|. ....|.:||    |.|....|.              
Human   514 CIDLIEAKLVGILDILDEENRLPQPSDQHFTSAVHQKH----KDHFRLTIPRKSKLAVHRNIRDD 574

  Fly   815 ----VAHYTGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQ 875
                :.|:.|.:.|:|..|.:.|.|.:...:......|.|:.|..:|.:             :..
Human   575 EGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFES-------------STN 626

  Fly   876 HKDESERKSYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYK 940
            :..::::|:..|:.:|.|     |..:|.        |.||  |.:..:.|..|:|||:.:|:..
Human   627 NNKDTKQKAGKLSFISVG-----NKFKTQ--------LNLL--LDKLRSTGASFIRCIKPNLKMT 676

  Fly   941 PRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDN----CR 1001
            ...|....:..|::..|::..:...|.|:.||..|.|....|:...     |.::.:.:    |:
Human   677 SHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKKYM-----PDKLARLDPRLFCK 736

  Fly  1002 LLF--LRLKMEGWALGKTKVFLR-----------YYNDEFLARLYELQVKKVIKVQSMMRALLAR 1053
            .||  |.|....:..|.||||.|           ..:.:.||.|    ||:|....:..|    .
Human   737 ALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL----VKRVNHWLTCSR----W 793

  Fly  1054 KRVK--GGKVFKLGKKGPEHHDVAASKIQKAFRGF----RDRVRLPPLVNEKSGQLNENTADF 1110
            |:|:  ...|.|| |...::...|..|:||..|.:    |.:.|:..||  |.|.|.:....|
Human   794 KKVQWCSLSVIKL-KNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLV--KVGTLKKRLDKF 853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ninaCNP_523503.2 STKc_myosinIII_N_like 9..282 CDD:270785 16/66 (24%)
MYSc_Myo21 346..1022 CDD:276848 181/735 (25%)
MYO6NP_001355794.1 MYSc_Myo6 71..759 CDD:276833 183/744 (25%)
Responsible for slow ATPase activity. /evidence=ECO:0000250|UniProtKB:Q29122 273..317 8/43 (19%)
Actin-binding. /evidence=ECO:0000255 665..672 4/6 (67%)
CBD_MYO6-like 770..917 CDD:409646 26/95 (27%)
Required for binding calmodulin. /evidence=ECO:0000250|UniProtKB:Q29122 782..810 9/32 (28%)
Three-helix bundle. /evidence=ECO:0000250|UniProtKB:Q29122 835..916 7/21 (33%)
SAH. /evidence=ECO:0000269|PubMed:18511944 917..984
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 934..955
MYO6_MIU_linker 999..1068 CDD:412090
Interaction with TAX1BP1 and CALCOCO2/NDP52. /evidence=ECO:0000269|PubMed:31371777 1060..1285
MyUb_Myo6 1082..1122 CDD:439319
Interaction with OPTN. /evidence=ECO:0000250|UniProtKB:Q9I8D1 1116..1118
Interaction with TOM1. /evidence=ECO:0000269|PubMed:31371777 1157..1285
Myosin-VI_CBD 1177..1267 CDD:465157
Blue background indicates that the domain is not in the aligned region.

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