Protein Alignment ninaC and MYO5B

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001073936.1
• Gene: MYO5B / 4645
• HGNCID: 7603
• Length: 1848
• Species: Homo sapiens
• Alignment Length: 1222
• Identity: 293/1222 - (23%)
• Similarity: 510/1222 - (41%)
• Gaps: 217/1222 - (17%)

  Fly   286 IENEDEM-RSDIAEMLELSRDVKTLYKEPELFVDRGYVKRFDEKPEKMYPED-----LAALENP- 343
            |.:.||: ||     .||::|    |||.    |:....|.:::....||.|     |..|.||
Human    15 IPDPDEVWRS-----AELTKD----YKEG----DKSLQLRLEDETILEYPIDVQRNQLPFLRNPD 66

  Fly   344 --VDEN------------IIESLRHRILMGES---YSFIGDILLSLNSNEIKQEFPQEFHAKYRF 391
              |.||            ::.:|:.|.|  ||   |::.|.:|:::|..|....:.|:....|..
Human    67 ILVGENDLTALSYLHEPAVLHNLKVRFL--ESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSG 129

  Fly   392 KSRSENQPHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATG-- 454
            ::..:..||||:||:.||:.|...::.|.|::||||.:||:.:|:..:::...:| |:...|.
Human   130 QNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVG-GSASETNIE 193

  Fly   455 -RVESSIKAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHN 518
             :|.:|...:..:.||.|..|::|:|......:.|.|...:.||....|:|||.||......:.|
Human   194 EKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERN 258

  Fly   519 FHIFYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRD 583
            :||||......... :.||..|.:..::.|.....:.....:    ||.| :.|:.|:...:| .
Human   259 YHIFYQLCAAAGLP-EFKELALTSAEDFFYTSQGGDTSIEGV----DDAE-DFEKTRQAFTLL-G 316

  Fly   584 IDFNHKQLETVRKVLAAILNIGN--IRFRQNGKYAEVENTDI-VSRIAELLRVDEKKF-MWSLTN 644
            :..:|:.  ::.|::|:||::|:  |:..::|....:...|: :|....||.|:..:. .|
Human   317 VKESHQM--SIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHW---- 375

  Fly   645 FIMVKGGIAERRQYTTEEAR----------DARDAVASTLYSRLVDFIINRIN--MNMSFPRAVF 697
                   :..|:..||.|..          :||:|:|..:|::|..:|:..||  ::.|..:..|
Human   376 -------LCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSF 433

  Fly   698 GDTNAIIIHDMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDN 762
                 |.:.|::|||.|..|..||..||..||::|..:|..:|..|..|...|.|....::||||
Human   434 -----IGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDN 493

  Fly   763 KTALDNLLTKPDGLFYIIDDASRSCQ-----DQDLIMDRVSEKHS---QFVK-KHTATEISVAHY 818
            :..:| |:....|:..::|:   .|:     ||:. ..::.::||   .|.| :.:.|...:.|:
Human   494 QPCID-LIEAKLGILDLLDE---ECKVPKGTDQNW-AQKLYDRHSSSQHFQKPRMSNTAFIIVHF 553

  Fly   819 TGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERK 883
            ..::.|.:..|.:.|||.|..|.|...::|....:..:|.:...       |..|......|..|
Human   554 ADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKD-------PVPATTPGKGSSSK 611

  Fly   884 SYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGV-HFVRCIRADLEYKPRSFHSD 947
            ....:......:|...:.:|:...||    |.|.:|.:..|... |:||||:.:.|..|..|...
Human   612 ISVRSARPPMKVSNKEHKKTVGHQFR----TSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPK 672

  Fly   948 VVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEPVEMTKDNCRLLFLRL--KME 1010
            ...||::|.|||:|:.....|:.||..:.:|..||:.|....:......|..||.:...|  ..:
Human   673 RAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPD 737

  Fly  1011 GWALGKTKVFLRYYNDEFLARLYELQVKK----VIKVQSMMRALLAR---KRVKGGKVF------ 1062
            .:..|:||:|.|...   :|.|.:|:..|    .|.:|..:|..|.:   .|:||..:.
Human   738 KFQFGRTKIFFRAGQ---VAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCR 799

  Fly  1063 -KLGKKGPEH--HDVAASKIQKAFRGFR-----DRVRLPPLVNEKSGQLNENTADFIRPFAKKWR 1119
             .|.::..||  ...||..:||.:|..|     .|||...:|.:..     ..|.|:|
Human   800 GHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAF-----TRAMFVR------- 852

  Fly  1120 EKSIFQVLLHYRAARFQDFVN--LSQQVHIYNQRMVAGLNKCT-------RAVPFERINMREVNS 1175
             ::..|||:.::|...|..|.  :::: |....|..|.:.:|.       |.:...||..|  ::
Human   853 -RTYRQVLMEHKATTIQKHVRGWMARR-HFQRLRDAAIVIQCAFRMLKARRELKALRIEAR--SA 913

  Fly  1176 SQLGPLPVPIKKMPFRLDQIPFYDTQYMVDPAN----SISRQ-AFPNQLLTQHMEDDEPWDSPLQ 1235
            ..|..|.|.::....:|        |..:|..|    ::|.| :......|..:|..:......|
Human   914 EHLKRLNVGMENKVVQL--------QRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQ 970

  Fly  1236 RNPSM-TSCALTYNAYKKEQACQTNWDRMGESDNIYNQGYFRDPQQLRRNQMQMNMNAYNNAYNS 1299
            ::|.. ||..|    .::.::.:|...|......|....:.|:..:||:....:...  |.....
Human   971 QSPGEDTSLRL----QEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQE--NALLKD 1029

  Fly  1300 YNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNNPNQQQRNYQQRSSYPPSDPVR 1364
            .....|||.....:....:||:|              .|..:....:::..||        :.|:
Human  1030 EKEQLNNQILCQSKDEFAQNSVK--------------ENLMKKELEEERSRYQ--------NLVK 1072

  Fly  1365 ELQNMARNEGDNSEDP-------------PFNFKAMLRKTNYPRGSETNTYD 1403
            |...:.:.. ||..|.             |.|..::...:|||..|.:...|
Human  1073 EYSQLEQRY-DNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGD 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	186/721 (26%)
MYO5B	NP_001073936.1	Requires for interaction with LIMA1. /evidence=ECO:0000269|PubMed:29880681	21..40		9/31 (29%)
		MYSc_Myo5	83..749	CDD:276831	184/709 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..630		5/40 (13%)
		Actin-binding. /evidence=ECO:0000255	640..662		8/21 (38%)
		IQ	811..833	CDD:197470	6/21 (29%)
		IQ	860..881	CDD:197470	4/21 (19%)
		SMC_prok_B	897..>1463	CDD:274008	48/266 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1093..1123		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1166..1192
		Myo5b_CBD	1474..1845	CDD:271261