Protein Alignment ninaC and MYO1E

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_004989.2
• Gene: MYO1E / 4643
• HGNCID: 7599
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1250
• Identity: 294/1250 - (23%)
• Similarity: 511/1250 - (40%)
• Gaps: 306/1250 - (24%)

  Fly   335 EDLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQP 399
            :|:..|....:.:|:|:|:.|.:....:::||.:|:|:|..:....|.::....|:..::.||.|
Human    22 DDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPP 86

  Fly   400 HIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYLGDGNRGATGRVESSIKAIL 464
            ||:::||..|::|:..:|.|.:::||||.:||:..|:.::.::..:..|     |.....:|.|:
Human    87 HIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGG-----GTKVQHVKDII 146

  Fly   465 M--------LVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHI 521
            :        ..||.|..||:|:|....:.:.|...|:..|...:.::|||.||...:..:.:|||
Human   147 LQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHI 211

  Fly   522 FYYFYDFINQQNQLKEYNLKADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDID- 585
            ||...:..:.: |.....:.:...|.||.:..       .|:.||    ::..|||:..|..::
Human   212 FYQLIEGASAE-QKHSLGITSMDYYYYLSLSG-------SYKVDD----IDDRREFQETLHAMNV 264

  Fly   586 ---FNHKQLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIM 647
               |..:| ..|.:::|.||::|||.|::.|.||.||:.:.::..|.||.:::.:....||:..|
Human   265 IGIFAEEQ-TLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQM 328

  Fly   648 VK--GGIAERRQYT--TEEARDARDAVASTLYSRLVDFIINRINMNMSFPRAVFGDTNAIIIHDM 708
            ..  ||.:|....|  .|:|...|||:|..|::|:.||:::.||..|......:.    |.:.|:
Human   329 DSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYN----IGVLDI 389

  Fly   709 FGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAED-----IDTINLNFYDNKTALDN 768
            :|||.|.:||.||..||.:||::     |:|||...|:.|.|:     |....:.:::||...|.
Human   390 YGFEIFQKNGFEQFCINFVNEKL-----QQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDL 449

  Fly   769 LLTK--PDGLFYIIDDASRSCQDQDLIMDRVSEKHSQFVKKHTATEIS-------------VAHY 818
            :..|  |.|:..|:||...:       |..|.|...|.:.:....:|.             :.||
Human   450 IENKVNPPGIMSILDDVCAT-------MHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHY 507

  Fly   819 TGRIIYDTRAFTDINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERK 883
            .|::.||...|.:.|||.:..::||..:||....|..:|...|              ..|:..|.
Human   508 AGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENL--------------QADKKGRP 558

  Fly   884 SYALNTLSAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDV 948
            :.|.:.:.    .|.|:|.:          ||:|...       |::|||:.:...|||.:....
Human   559 TTAGSKIK----KQANDLVS----------TLMKCTP-------HYIRCIKPNETKKPRDWEESR 602

  Fly   949 VQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQFL------AFDFDEPVEMTKDNCRLLFLRL 1007
            |:.|::.||:.:.:..|:.|::.|..|.:||:||..|      ::..:|     |.....|...:
Human   603 VKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEE-----KQGVLHLLQSV 662

  Fly  1008 KMEG--WALGKTKVFLRYYNDEFLARLYELQVKKVIKVQSMMRALLARKRVKGGKVFKLGKKGPE 1070
            .|:.  :.||::|||::.....||  |.|::.:|
Human   663 NMDSDQFQLGRSKVFIKAPESLFL--LEEMRERK------------------------------- 694

  Fly  1071 HHDVAASKIQKAFRGFRDRVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQVLL------- 1128
             :|..|..|||::|.|        :..:|..|:.|..:|.:.. .|:.|..||.:..:
Human   695 -YDGYARVIQKSWRKF--------VARKKYVQMREEASDLLLN-KKERRRNSINRNFIGDYIGME 749

  Fly  1129 -HYRAARF---QDFVNLSQQVHIYNQRMVAGLN-------KCTRAVPFERINMREVNSSQLGP-- 1180
             |....:|   ::.::.:..|..|::|. .|:.       ||...:..|::..        ||
Human   750 EHPELQQFVGKREKIDFADTVTKYDRRF-KGVKRDLLLTPKCLYLIGREKVKQ--------GPDK 805

  Fly  1181 -LPVPIKKMPFRLDQIPFYDTQYMVDPANSISRQAFPN-----------QLLTQHMEDDEPWDSP 1233
             |...:.|....:::|.......|.|....:..|.:.:           .||.:..|:......|
Human   806 GLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLP 870

  Fly  1234 LQRNPSMTSCALTYNAYKKEQACQTNWD--RMGESDNI-YNQGYFRDPQQLR------------- 1282
            |:.:.::..      ..|||     ||.  ..|.|..: ::|| |.|...|:
Human   871 LKFSNTLEL------KLKKE-----NWGPWSAGGSRQVQFHQG-FGDLAVLKPSNKVLQVSIGPG 923

  Fly  1283 --RNQMQMNMNAYNNAYNSYNSNYNNQNWGVHRSGSRRNSLKGYAAPPPPPPPMPSSNYYRNN-- 1343
              :|......|...|  ..|:|...|.|:.|.            ||||||       .|::|.
Human   924 LPKNSRPTRRNTTQN--TGYSSGTQNANYPVR------------AAPPPP-------GYHQNGVI 967

  Fly  1344 ----------PNQQQRNYQQRSSYPPSDPVRELQNMARNEGDNSEDPPFNFKAMLRKTNYPRGSE 1398
                      |..|:.|  |:|.|         .:|||        ||.   ...:.|:..|.|:
Human   968 RNQYVPYPHAPGSQRSN--QKSLY---------TSMAR--------PPL---PRQQSTSSDRVSQ 1010

  Fly  1399 T-NTYDFNNRRGSDSGDQHTFQPPKLRSTGRRYQDDEGYNSSSGNYGVSRKFGQQQRAPTLRQSP 1462
            | .:.||             .:.|...:.|.|.|.......:.|     |...|.:..|.:.|..
Human  1011 TPESLDF-------------LKVPDQGAAGVRRQTTSRPPPAGG-----RPKPQPKPKPQVPQCK 1057

  Fly  1463 ASVGRSFEDSNARSF 1477
            |......:|::..||
Human  1058 ALYAYDAQDTDELSF 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	192/719 (27%)
MYO1E	NP_004989.2	MYSc_Myo1	33..679	CDD:276829	192/719 (27%)
		Actin-binding. /evidence=ECO:0000255	581..591		4/16 (25%)
		Myosin_TH1	719..920	CDD:461801	40/222 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..966		16/67 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	993..1053		18/88 (20%)
		SH3_MyoIe_If_like	1056..1107	CDD:212761	3/16 (19%)