Protein Alignment ninaC and MYO1D

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 215/843 - (25%)
• Similarity: 389/843 - (46%)
• Gaps: 118/843 - (13%)

  Fly   336 DLAALENPVDENIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQPH 400
            |...::.......:.:||.|...|..|:|||::::|:|..::...:.::...:|:.:...|..||
Human    13 DFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPH 77

  Fly   401 IFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIKHLCYL-GDGNRGATGRVESS-IKAI 463
            :|::||.||:.|....:...||:||||.:||:..::.:::::..: ....|....||::. :|:.
Human    78 LFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSN 142

  Fly   464 LMLV---NAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYF 525
            .:|.   ||.|..|::|:|......:.|...|...|...|.|:|||.||......:.:||.||..
Human   143 CVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQL 207

  Fly   526 YDFINQQNQLKEYNL-KADRNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHK 589
            ....::| .|:..:| |:..:|.|:.|     .::||...:|    ...:|...:.::.|.|..:
Human   208 LQGGSEQ-MLRSLHLQKSLSSYNYIHV-----GAQLKSSIND----AAEFRVVADAMKVIGFKPE 262

  Fly   590 QLETVRKVLAAILNIGNIRFRQNGKYAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIAE 654
            :::||.|:|||||::||::|..:|....:||..:||.|||||.........:|....:..|....
Human   263 EIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDII 327

  Fly   655 RRQYTTEEARDARDAVASTLYSRLVDFIINRINMNM---SFPRAVFGDTNAIIIHDMFGFECFNR 716
            .:|:|.:||...|||.|..:|.||..:|:.|||..:   ::...:.|....|.:.|::|||.|:.
Human   328 DKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDN 392

  Fly   717 NGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYIID 781
            |..||..||..||::|..:.|.:...|..|.:.|.|...::::::|:..:|.:..:..|:..|:|
Human   393 NSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILD 457

  Fly   782 DASRSCQDQDLIMDRV--------SEKHSQFVKKHTAT---------EISVAHYTGRIIYDTRAF 829
            ||   |.:...:.|.:        ..||:.|..:....         :..:.||.|.::|....|
Human   458 DA---CMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDVVYSVIGF 519

  Fly   830 TDINRDFVPPEMIETFRSSLDESIMLMFTNQLTK----AGNLTMPFEAVQHKDESERKSYALNTL 890
            .|.|:|    .:.:.|:     .:|...:|.:.|    .|.|::       .:.::|...|....
Human   520 IDKNKD----TLFQDFK-----RLMYNSSNPVLKNMWPEGKLSI-------TEVTKRPLTAATLF 568

  Fly   891 SAGCISQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKA 955
            ....|:.|:||                     |:...::||||:.:.:..|:.|..:..:.|::.
Human   569 KNSMIALVDNL---------------------ASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEY 612

  Fly   956 LGVLDTVIARQKGFSSRLPFDEFLRRYQFLAFDFDEP---VEMTKDNCRLLFLRLK-MEGWALGK 1016
            ||:|:.|..|:.||:.|..:::||.||:.:: :|..|   :...|:..:.|..|.. .:..|.||
Human   613 LGLLENVRVRRAGFAFRQTYEKFLHRYKMIS-EFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGK 676

  Fly  1017 TKVFLRYYNDEFLARLYELQVKKVIKV----QSMMRALLARKRVKGGKV-------FKLGKKGPE 1070
            ||:|:|  ....|..|.||:.:.:|::    |.:.|..|||.|.|..|.       ::..|....
Human   677 TKIFIR--TPRTLFTLEELRAQMLIRIVLFLQKVWRGTLARMRYKRTKAALTIIRYYRRYKVKSY 739

  Fly  1071 HHDVAASKIQKAFRG---FRD-----RVRLPPLVNEKSGQLNENTADFIRPFAKKWREKSIFQ 1125
            .|:||     :.|.|   .||     :...||.|..:       ..:.::....:||...:.:
Human   740 IHEVA-----RRFHGVKTMRDYGKHVKWPSPPKVLRR-------FEEALQTIFNRWRASQLIK 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	187/709 (26%)
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	187/708 (26%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		9/42 (21%)
		Myosin_TH1	803..996	CDD:461801