Protein Alignment ninaC and MYO1C

DIOPT Version :10

• Sequence 1: NP_523503.2
• Gene: ninaC / 34012
• FlyBaseID: FBgn0002938
• Length: 1501
• Species: Drosophila melanogaster
• Sequence 2: NP_001074248.1
• Gene: MYO1C / 4641
• HGNCID: 7597
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 1020
• Identity: 248/1020 - (24%)
• Similarity: 429/1020 - (42%)
• Gaps: 163/1020 - (15%)

  Fly   335 EDLAALENPVDE-NIIESLRHRILMGESYSFIGDILLSLNSNEIKQEFPQEFHAKYRFKSRSENQ 398
            :|...|||...| ..||:||.|......|::||.:|:|:|.....|.:.::...:||..|..|..
Human    49 QDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVP 113

  Fly   399 PHIFSVADIAYQDMLHHKEPQHIVLSGESYSGKSTNARLLIK---HLCYLGDGNRGATGRVESSI 460
            ||:|:|||..|:.:...:..|.:::||||.:||:...:.|::   ..|...:.......|:..|.
Human   114 PHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSN 178

  Fly   461 KAILMLVNAGTPVNNDSTRCVLQYCLTFGKTGKMSGAVFNMYMLEKLRVATTDGTQHNFHIFYYF 525
            ..:....||.|..|::|:|......:.|...|...|.....|:|||.||...:..:.||||||..
Human   179 PVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQL 243

  Fly   526 YDFINQQNQLKEYNLKAD-RNYRYLRVPPEVPPSKLKYRRDDPEGNVERYREFENILRDIDFNHK 589
            .:. .::..|:...|:.: ::|.||........|.:..:.|        ::.....|..|||...
Human   244 LEG-GEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSD--------WKVVRKALTVIDFTED 299

  Fly   590 QLETVRKVLAAILNIGNIRFRQNGK-YAEVENTDIVSRIAELLRVDEKKFMWSLTNFIMVKGGIA 653
            ::|.:..::|::|::|||.|..|.: .|:|...:.:..:..||.|:......:||:..::..|..
Human   300 EVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEE 364

  Fly   654 ERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMS---FPRAVFGDTNAIIIHDMFGFECFN 715
            .......|:|..||||:|..:|||...:::.:||.:::   .....:..|..:.:.|::|||.|.
Human   365 LLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQ 429

  Fly   716 RNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFYDNKTALDNLLTKPDGLFYII 780
            .|..||..||..||::|..:.:....||..|.|||.|....:.:::||...|.:..|..|:..|:
Human   430 HNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISIL 494

  Fly   781 D-DASRSCQDQDLI----MDRVSEKHSQFVKKHTAT----------EISVAHYTGRIIYDTRAFT 830
            | :..|..:..||.    ::...:.|..|:....|.          |..:.||.|.:.|....|.
Human   495 DEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFL 559

  Fly   831 DINRDFVPPEMIETFRSSLDESIMLMFTNQLTKAGNLTMPFEAVQHKDESERKSYALNTLSAGCI 895
            |.|.|.:...:.||..||.:..:...|                    |.||             :
Human   560 DKNNDLLFRNLKETMCSSKNPIMSQCF--------------------DRSE-------------L 591

  Fly   896 SQVNNLRTLAANFRFTCLTLLKMLSQNANLGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLD 960
            |......|:|..|:.:.|.|:::|......   :||||:.:...:|..|...:::.|:|.||:|:
Human   592 SDKKRPETVATQFKMSLLQLVEILQSKEPA---YVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLE 653

  Fly   961 TVIARQKGFSSRLPFDEFLRRYQFLAFD-FDEPVEMTKDNCRLLFLRL--KMEGWALGKTKVFLR 1022
            .:..|:.||:.|..::.||:||:.|..: :.......:|...:|...|  |.|.:.:|:||:|:|
Human   654 NLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIR 718

  Fly  1023 YYNDEFLARLYELQVKK---VIKVQSMMRALLARK---RVKGGKVF-------KLGKKGPEHHDV 1074
            :....| |....|:|::   ..|:|:..|....|:   |||...:.       .||::.......
Human   719 FPKTLF-ATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKW 782

  Fly  1075 AASKIQKAFRG--------------FRDRVRLPPLVNEKSGQLNENTAD--------FIRPFAKK 1117
            ||..|::..||              |.|.||...|:|.:. ||.:|..|        .:|..::.
Human   783 AAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRR-QLPQNVLDTSWPTPPPALREASEL 846

  Fly  1118 WREKSIFQVLLHYRAARFQDFVNLSQQVHIYNQRMVAGLNKCTRAVP----FERINMREVNS--- 1175
            .||..|..::..|..:...::....||..:.::......:...::||    ..|:...|::.
Human   847 LRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVL 911

  Fly  1176 SQLGPLP----VPIKKMPFRLDQIPFYD-------------------------TQYMVDPAN--S 1209
            ..||..|    ||:.|          ||                         .:..:|.||  .
Human   912 QALGSEPIQYAVPVVK----------YDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTG 966

  Fly  1210 ISRQAFPNQLLTQHM---EDDEPWDSPLQRN---PSMTSCALTYN 1248
            ||..:..:.|...|:   ::.:..|..||.:   .::|..||:.|
Human   967 ISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTALSAN 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaC	NP_523503.2	STKc_myosinIII_N_like	9..282	CDD:270785
		MYSc_Myo21	346..1022	CDD:276848	182/702 (26%)
MYO1C	NP_001074248.1	MYSc_Myo1	62..718	CDD:276829	181/700 (26%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		7/24 (29%)
		IQCG	751..781	CDD:467744	6/29 (21%)
		Myosin_TH1	874..1055	CDD:461801	26/148 (18%)